Insights in Molecular Therapies for Hepatocellular Carcinoma

Dear Colleagues,

Hepatocellular carcinoma (HCC) stands as one of the most prevalent and lethal forms of cancer globally. The complexity of liver cancer, as well as the often late-stage diagnosis and limited efficacy of current treatments, underscores the urgent need for novel therapeutic strategies. This Special Issue aims to gather cutting-edge research on innovative treatments for HCC. We are particularly interested in studies that explore new molecular targets, advancements in immunotherapy, the application of precision medicine and combination therapy in treating HCC.

We invite researchers to contribute original research papers and comprehensive reviews that shed light on novel therapeutic approaches for HCC. Potential topics include, but are not limited to:

1. Exploration of new molecular targets: Studies focusing on identifying and characterizing novel molecular targets in HCC.
2. The comeback of tumor biopsy: Addressing the pros and cons of tumor biopsy.
3. The use of liquid biopsy to identify targets: Evaluating current available tests and reviews of potential future markers.
4. Immunotherapy for HCC: Papers detailing new findings in immunotherapy, including checkpoint inhibitors, CAR-T cell therapy and vaccine-based approaches.
5. Precision medicine in HCC: Studies exploring the role of precision medicine, including personalized treatment strategies based on genetic, epigenetic and proteomic profiling.
6. Combination therapies: Research on the efficacy of combining traditional treatments with novel therapies such as locoregional therapy and immunotherapy.
7. Exploration of success using new therapies and/or combination therapy for downstaging advanced HCC for a potential liver transplant: We are interested in any current case series, and even small-scale studies, addressing this issue.
8. Advancements in drug delivery systems: Research on innovative methods for drug delivery, including nanoparticles, liposomes and targeted delivery mechanisms.

Dr. Christine Pocha
Guest Editor

Manuscript Submission Information

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• hepatocellular carcinoma
• molecular targets
• immunotherapy
• gene therapy
• targeted therapy
• precision medicine
• combination therapy
• clinical trials
• preclinical study
• drug delivery systems