Molecular Mechanisms and Treatment of Migraine

Dear Colleagues,

This special issue explores the intricate molecular mechanisms underlying migraine, a debilitating neurological disorder characterized by recurrent episodes of severe headache, often accompanied by sensory disturbances. Recent scientific advances have elucidated the pathophysiological pathways involved in migraine, including the central role of neurotransmitters, ion channels, and inflammatory processes. Calcitonin gene-related peptide (CGRP), have already entered clinical practice and are showing positive results in migraine patients by providing targeted efficacy without significant side effects. Understanding these mechanisms is critical to the development of targeted therapies that can alleviate the suffering of millions of people worldwide.

In this issue, we aim to bring together original research articles and comprehensive reviews that explore the genetic, biochemical, and environmental factors that contribute to migraine. In addition, we highlight novel therapeutic strategies, ranging from pharmacological interventions, such as pituitary adenylate cyclase activating polypeptide (PACAP) and nitric oxide synthase (NOS), to neuromodulation techniques. These approaches aim to prevent or reduce the frequency and severity of migraine attacks. By synthesizing the latest findings from molecular biology, clinical trials, and therapeutic innovation, this issue aims to advance our understanding and treatment of migraine.

Dr. Noboru Imai
Guest Editor

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• migraine
• nitric oxide synthase (NOS)
• neuropeptides
• calcitonin gene-related peptide (CGRP)
• pituitary adenylate cyclase activating polypeptide (PACAP)
• molecular pathways
• therapeutic targets
• neurovascular condition