Acute Respiratory Distress Syndrome (ARDS): New Insights into the Mechanisms and Emerging Therapies

Dear Colleagues,

A Special Issue on “Acute Respiratory Distress Syndrome (ARDS): New Insights into the Mechanisms and Emerging Therapies” is being prepared for the journal IJMS. ARDS is a form of acute-onset hypoxemic respiratory failure with bilateral pulmonary infiltrates that is caused by acute inflammatory edema of the lungs and is not attributable to left-sided heart failure. Common causes of ARDS include sepsis, pneumonia, COVID-19, burns, major trauma with shock and massive transfusion. There are currently no effective pharmacological or cell-based treatments for the disease, and the mortality rate remains as high as 40%. An intractable endothelial and epithelial barrier injury is the characteristic feature which leads to protein-rich alveolar edema. The repair of the injured endothelial and epithelial barriers is critically important for patient recovery and survival. Thus, studies to understand the molecular mechanisms of injury repair and the regeneration of the endothelial and epithelial barriers are fundamental for developing novel, effective therapies for ARDS. This Special Issue invites submissions of original research articles and reviews focused on the molecular mechanisms of these processes and emerging therapies to inhibit injury and/or promote repair and regeneration, as well as the resolution of inflammatory lung injury.

Prof. Dr. Youyang Zhao
Guest Editor

Manuscript Submission Information

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• acute lung injury
• ARDS
• endothelial barrier
• epithelial barrier
• acute inflammation
• repair
• regeneration
• resolution of inflammation