Alzheimer’s Disease: Molecular Mechanisms and Pharmacological Approaches

Dear Colleagues,

Alzheimer's disease, a devastating chronic neurodegenerative disorder, is thought to affect 60% to 70% of the approximately 55 million individuals worldwide who suffer from dementia. Early symptoms of the condition involve forgetting recent events or discussions. It eventually leads to severe memory issues and the inability to execute daily duties. Several attempts have been undertaken to discover novel therapies that alter the development of Alzheimer's disease. Unfortunately, this research has not resulted in the effective development and identification of novel pharmacological treatments. As a result, understanding the molecular pathways behind damage and neuroprotection is critical for developing innovative therapeutic medicines.

The purpose of this Special Issue is to provide current overviews of the molecular causes of as well as possible therapeutic strategies for Alzheimer's disease. We encourage authors to contribute original research papers and reviews concerning molecular processes and pharmacological interventions in the field, with a focus on, but not limited to, the molecular and mechanistic bases for neuroinflammation and G protein-coupled receptor modulation.

Dr. Stefania Merighi
Dr. Stefania Gessi
Guest Editors

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• Alzheimer’s disease
• drug discovery
• G protein-coupled receptors
• molecular mechanisms
• neuroinflammation
• target validation
• therapeutic effects