State-of-the-Art Molecular Toxicology in the Netherlands

Dear Colleagues,

Molecular toxicology is a discipline that studies the molecular mechanism underlying the unwanted effects of compounds, in general xenobiotics. It is situated at the cutting edge of chemistry and biology, and their relation to health. The focus is on the molecule and its interaction with biomolecules. The toxicity of compounds is ‘selective’ because the observed adverse effects of compounds differ between species and individuals, compounds generally display a toxicity that is restricted to a specific organ, and compounds induce a specific type of toxicity. The generation of reactive intermediates and metabolites is often key in the actual toxicity of compounds. Therefore, the role of metabolism in the formation of metabolites and reactive intermediates, and the protection against these species is extensively studied.

This Topical Collection aims to give a broad overview of the State-of-the-Art research on Molecular Toxicology performed in the Netherlands. Topics include the molecular mechanisms determining (selective) toxicity in living organisms, and appropriate in vitro and in silico models; the versatility of enzymes, such as cytochrome P450 and glutathione S-transferases in the biotransformation of compounds; consequences of genetic polymorphisms of biotransformation enzymes; chemical and biological properties of various classes of reactive intermediates; structure-activity relationships, toxicogenomics and other approaches applied to predict toxicity. Also articles on strategies to reduce toxicity, as well as on new concepts in toxicology are welcome.

The areas of interest include, but are not limited to:

• Food, drug and chemical toxicology
• Genetic toxicology
• Reproductive toxicology
• Neurotoxicology
• Clinical toxicology
• Nanotoxicology
• Environmental and ecotoxicology
• Computational and predictive toxicology
• Food-drug interactions
• Idiosyncratic toxicity
• Toxins
• Redox-modulation

Prof. Dr. Guido R.M.M. Haenen
Collection Editor

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