Genetic specificity information “seen by” the transcriptase is in terms of hydrogen bonded proton states, which initially are metastable amino (–NH2
) and, consequently, are subjected to quantum uncertainty limits. This introduces a probability of arrangement, keto-amino → enol-imine
, where product protons participate in coupled quantum oscillations at frequencies of ~ 1013
and are entangled. The enzymatic ket for the four G′-C′ coherent protons is │ψ > = α│+ − + − > + β│+ − − + > + γ│− + + − > + δ│− + − + >. Genetic specificities of superposition states are processed quantum mechanically, in an interval ∆t < < 10−13
s, causing an additional entanglement between coherent protons and transcriptase units. The input qubit at G-C sites causes base substitution, whereas coherent states within A-T sites cause deletion. Initially decohered enol and imine G′ and *C isomers are “entanglement-protected” and participate in Topal-Fresco substitution-replication which, in the 2nd round of growth, reintroduces the metastable keto-amino state. Since experimental lifetimes of metastable keto-amino states at 37 °C are ≥ ~3000 y, approximate quantum methods for small times, t < ~100 y, yield the probability, P(t), of keto-amino → enol-imine
(t) = ½ (γρ
. This approximation introduces a quantum Darwinian evolution model which (a) simulates incidence of cancer data and (b) implies insight into quantum information origins for evolutionary extinction.