Revascularization Strategies in Peripheral Artery Disease and Chronic Limb-Threatening Ischemia: Current Standards and Future Perspectives

Dear Colleagues,

The prevalence of peripheral artery disease (PAD) and, in particular, chronic limb-threatening ischemia (CLTI) is increasing globally, not only in high-income countries but also in middle- and low-income countries. The rise in PAD and CLTI is leading to an increased need for, and complexity of, peripheral revascularizations, especially for below-the-knee (BTK) pathologies. The treatment of PAD has changed significantly over the past few decades, and an endovascular-first strategy has been adopted in most centers. In the contemporary era of endovascular therapy for PAD and CLTI, developments and innovations have followed each other at a great pace. Over the years, image guidance, endovascular materials, and revascularization techniques have evolved, enabling us to treat more complex cases. On one hand, the evolution of endovascular revascularization for the treatment of PAD opens doors for innovations related to interventional planning, imaging, techniques, the application of artificial intelligence (AI), and patient selection. On the other hand, there are also drawbacks, such as the negative effects of radiation exposure, discussions regarding long-term patency, and cost-effectiveness issues, which raise new research questions. This Special Issue will address topics that can keep us in the loop and help us to achieve faster, more effective, cheaper, and safer interventions, beneficial for (future) patients, interventionalists, and the healthcare system.

We would like to invite you to contribute an original research or review article to this Special Issue.

Dr. Constantijn E.V.B. Hazenberg
Dr. Martin Teraa
Guest Editors

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• peripheral arterial disease (PAD)
• chronic limb-threatening ischemia (CLTI)
• below the knee
• atherosclerosis
• endovascular intervention
• endovascular therapies
• image-guided therapies