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Advanced Biomaterials for Wound Healing
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Advanced Biomaterials for Wound Healing

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 October 2016) | Viewed by 19671

Special Issue Editor

Prof. Dr. Kazuo Azuma

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Guest Editor
Department of Veterinary Neurology and Oncology, Faculty of Agriculture, Tottori University, 4-101 Koyama-minami, Tottori 680-8533, Japan
Interests: chitin; chitosan; functional food; wound healing; chitin nanofiber
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wound healing is a dynamic interactive process that involves parenchymal cells, extracellular matrix, blood cells, and soluble mediators. The three phases of wound healing are the inflammatory, proliferative, and the tissue re-modeling phases. Thus far, many researchers have been developing the studies of wound healing. Many criteria are used for the classification of wound dressings. These include classification based on the physical form of the dressing, such as gels, ointments, creams, films, and scaffolds. In fact, efficiencies of many biomaterials are indicated. More recently, nano-based biomaterials have been developing. The aim of this Special Issue is to discuss advanced, innovative, and functional biomaterials for wound healing. Research, review, and future articles, focusing on the related fields, are welcome.

Prof. Dr. Kazuo Azuma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • inflammation
  • proliferation
  • re-modeling
  • biomacropmolecules
  • nanotechnology
  • wound dressing
  • biomaterials
  • scafforld
  • tissue engineering

Published Papers (3 papers)

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Research

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1434 KiB  
Article
Induction of Low-Level Hydrogen Peroxide Generation by Unbleached Cotton Nonwovens as Potential Wound Dressing Materials
by J. Vincent Edwards, Nicolette T. Prevost, Sunghyun Nam, Doug Hinchliffe, Brian Condon and Dorne Yager
J. Funct. Biomater. 2017, 8(1), 9; https://doi.org/10.3390/jfb8010009 - 06 Mar 2017
Cited by 8 | Viewed by 6175
Abstract
Greige cotton is an intact plant fiber. The cuticle and primary cell wall near the outer surface of the cotton fiber contains pectin, peroxidases, superoxide dismutase (SOD), and trace metals, which are associated with hydrogen peroxide (H2O2) generation during [...] Read more.
Greige cotton is an intact plant fiber. The cuticle and primary cell wall near the outer surface of the cotton fiber contains pectin, peroxidases, superoxide dismutase (SOD), and trace metals, which are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. Traditionally, the processing of cotton into gauze involves scouring and bleaching processes that remove the components in the cuticle and primary cell wall. The use of unbleached, greige cotton fibers in dressings, has been relatively unexplored. We have recently determined that greige cotton can generate low levels of H2O2 (5–50 micromolar). Because this may provide advantages for the use of greige cotton-based wound dressings, we have begun to examine this in more detail. Both brown and white cotton varieties were examined in this study. Brown cotton was found to have a relatively higher hydrogen peroxide generation and demonstrated different capacities for H2O2 generation, varying from 1 to 35 micromolar. The H2O2 generation capacities of white and brown nonwoven greige cottons were also examined at different process stages with varying chronology and source parameters, from field to nonwoven fiber. The primary cell wall of nonwoven brown cotton appeared very intact, as observed by transmission electron microscopy, and possessed higher pectin levels. The levels of pectin, SOD, and polyphenolics, correlated with H2O2 generation. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Wound Healing)
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3699 KiB  
Article
Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films
by Lin Qiu, Nanayaa F. Hughes-Brittain, Cees W. M. Bastiaansen, Ton Peijs and Wen Wang
J. Funct. Biomater. 2016, 7(4), 33; https://doi.org/10.3390/jfb7040033 - 09 Dec 2016
Cited by 8 | Viewed by 5742
Abstract
Failures of vascular grafts are normally caused by the lack of a durable and adherent endothelium covering the graft which leads to thrombus and neointima formation. A promising approach to overcome these issues is to create a functional, quiescent monolayer of endothelial cells [...] Read more.
Failures of vascular grafts are normally caused by the lack of a durable and adherent endothelium covering the graft which leads to thrombus and neointima formation. A promising approach to overcome these issues is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. The present study reports for the first time on the use of photoembossing as a technique to create polymer films with different topographical features for improved cell interaction in biomedical applications. For this, a photopolymer is created by mixing poly(methyl methacrylate) (PMMA) and trimethylolpropane ethoxylate triacrylate (TPETA) at a 1:1 ratio. This photopolymer demonstrated an improvement in biocompatibility over PMMA which is already known to be biocompatible and has been extensively used in the biomedical field. Additionally, photoembossed films showed significantly improved cell attachment and proliferation compared to their non-embossed counterparts. Surface texturing consisted of grooves of different pitches (6, 10, and 20 µm) and heights (1 µm and 2.5 µm). The 20 µm pitch photoembossed films significantly accelerated cell migration in a wound-healing assay, while films with a 6 µm pitch inhibited cells from detaching. Additionally, the relief structure obtained by photoembossing also changed the surface wettability of the substrates. Photoembossed PMMA-TPETA systems benefited from this change as it improved their water contact angle to around 70°, making it well suited for cell adhesion. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Wound Healing)
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Review

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241 KiB  
Review
Minimizing Skin Scarring through Biomaterial Design
by Alessandra L. Moore, Clement D. Marshall and Michael T. Longaker
J. Funct. Biomater. 2017, 8(1), 3; https://doi.org/10.3390/jfb8010003 - 21 Jan 2017
Cited by 13 | Viewed by 7351
Abstract
Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system [...] Read more.
Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system alike. With this knowledge, the number of engineered products to facilitate wound healing has also increased dramatically, with some already in clinical use. In this review, the major biomaterials used to facilitate skin wound healing will be examined, with particular attention allocated to the science behind their development. Experimental therapies will also be evaluated. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Wound Healing)
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