Solubility and Solubilization of Drugs: Modeling and Thermodynamic Analysis
A special issue of Liquids (ISSN 2673-8015).
Deadline for manuscript submissions: 31 July 2024 | Viewed by 2978
Special Issue Editor
Interests: solubility; thermodynamic analysis; modeling and simulation
Special Issue Information
Dear Colleagues,
Solubility is one of the most important physicochemical properties in the research and development of pharmaceutical products since it affects their biopharmaceutical and pharmacokinetic characteristics. In this context, this Special Issue focuses on the development of strategies that improve the solubility of an active pharmaceutical ingredient (API), such as the use of cosolvents, surfactants, physical modification of the API, pH control, complex formation, and the use of co-solutes; these are some of the most relevant lines of research in pharmaceutical sciences presently.
In this context, understanding the energetic phenomena involved in the dissolution process allows understanding of the possible molecular interactions involved to be developed which, in turn, could facilitate the development of more rational and efficient design processes. In this way, the development of mathematical models, as well as the simulation of phenomena, have been consolidated as relevant research subjects in the area of solubility.
It is expected that this Special Issue will compile the experiences of different experts in the area, consolidating a document that, in addition to presenting the most recent advances in the subject of drug solubility, allows the subject to be theorized and the fundamental concepts of this topic to be strengthened.
Prof. Dr. Daniel Ricardo Delgado
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Liquids is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- solubility
- solubilization
- modeling
- thermodynamics
- co-solvency
- preferential solvation
- drugs
- molecular interactions
- phase equilibria