Marine Bioactive Compounds against Biofilm-Forming Microbial Pathogens

Dear Colleagues,

Microbial infection is regarded as one of the most serious human health concerns, and the death rate has lately risen as a result of microbial infections. Infections caused by bacterial (Gram-positive and Gram-negative) and fungal (e.g. Candida spp.) pathogens have received a lot of attention due to the development of diverse resistance mechanisms. These microbial pathogens have a variety of extrinsic and extrinsic antimicrobial resistance mechanisms. Furthermore, biofilm development is another adaptive resistance mechanism in which a microbial population is shielded by self-produced extracellular polymeric substances. Polymicrobial biofilm development is more clinically important than mono-species microbial biofilm formation because most microbe live in the form of a complex communities in their natural habitat. Furthermore, the microbial biofilm contains metabolically less active cells (known as persister cells), which have been identified as one of the key causes of persistent and recurring infections. To combat microbial infection, researchers throughout the world have developed numerous alternative strategies, one of which includes the inhibition of biofilms. Several research have also focused on the attenuation of virulence properties of microbial pathogens, which is another alternative strategy for microbial infection control. The marine organisms have been identified as one of the greatest natural sources for isolating bioactive compounds for therapeutic purposes. Many studies have shown that marine-derived bioactive compounds have potential antibiofilm activity against biofilm-forming microbial pathogens. In some cases, these marine-derived bioactive compounds have been used in the form of nanoformulation to reduce cytotoxicity and stability issues.

As Guest Editors for this Special Issue, we invite all researchers to submit their findings related to antibiofilm and antivirulence drugs derived from marine organisms for the upcoming Special Issue “Marine Bioactive Compounds against Biofilm-forming Microbial Pathogens

Dr. Fazlurrahman Khan
Prof. Dr. Young-Mog Kim
Dr. Manivasagan Panchanathan
Guest Editors

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• antibiofilm
• antivirulence
• polymicrobial biofilms
• infection
• bacterial pathogens
• fungal pathogens
• marine-bioactive molecules
• conjugation
• encapsulation
• nanoparticles