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Membranes
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Biocompatible Membranes for Bone Regeneration
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Biocompatible Membranes for Bone Regeneration

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biofilms".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 24325

Special Issue Editors

Dr. Ionela Andreea Neacsu

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Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
Interests: nanomaterials; drug delivery systems; biomimetic materials; biogenic calcium sources; composite scaffolds
Special Issues, Collections and Topics in MDPI journals
Dr. Vladimir-Lucian Ene

E-Mail Website
Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
Interests: thin films; interfaces; nanomaterials; thin films deposition methods; biomaterials; 3D printed scaffolds; advanced ceramics; characterization methods (X-ray diffraction and electron microscopy)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your work to this Special Issue on “Biocompatible Membranes for Tissue Regeneration”. The search for new tissue regeneration strategies is an international priority, fueled by the debilitating pain associated with bone diseases and the increasing challenge that our aging population represents from a medical and socioeconomic point of view. The most impressive studies on the synthesis and characterization methods, applications, and properties of membranes used in bone tissue engineering will be disseminated in the pursuit of a better and accessible biomaterial, which may represent the future of therapeutic clinical approaches. This Special Issue aims to gather experienced researchers, chemists, biologists, microbiologists, pharmacists, engineers, and medical specialists interested in topics linked to biocompatible membranes with prospective applications in tissue regeneration. 

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not be limited to) the following:

  • Nanoassembly and layer-by-layer nanotechnologies for membrane materials;
  • Characterization and analysis of membrane structure and function;
  • Ceramic membranes, metallic membranes, membranes from carbon-based materials;
  • Natural/synthetic polymeric membranes;
  • Nanostructured membranes;
  • 3D-printed biocompatible membranes for tissue regeneration;
  • Nanoparticle-loaded membranes for bone regeneration;
  • Membranes for guided bone regeneration;
  • Resorbable/non-resorbable membranes.

We look forward to receiving your contributions.

Dr. Ionela Andreea Neacsu
Dr. Vladimir-Lucian Ene
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • collagen membranes
  • bone augmentation
  • dentistry
  • barrier membrane
  • bi-layer structure
  • biocompatibility
  • calcium phosphate bone substitutes
  • natural compounds
  • cell migration

Published Papers (7 papers)

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Research

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13 pages, 3656 KiB  
Article
Small Intestinal Submucosa Biomimetic Periosteum Promotes Bone Regeneration
by Yanlin Su, Bing Ye, Lian Zeng, Zekang Xiong, Tingfang Sun, Kaifang Chen, Qiuyue Ding, Weijie Su, Xirui Jing, Qing Gao, Guixiong Huang, Yizhou Wan, Xu Yang and Xiaodong Guo
Membranes 2022, 12(7), 719; https://doi.org/10.3390/membranes12070719 - 20 Jul 2022
Cited by 4 | Viewed by 1939
Abstract
Background: Critical bone defects are a significant problem in clinics. The periosteum plays a vital role in bone regeneration. A tissue-engineered periosteum (TEP) has received increasing attention as a novel strategy for bone defect repairs. Methods: In this experiment, a biomimetic periosteum was [...] Read more.
Background: Critical bone defects are a significant problem in clinics. The periosteum plays a vital role in bone regeneration. A tissue-engineered periosteum (TEP) has received increasing attention as a novel strategy for bone defect repairs. Methods: In this experiment, a biomimetic periosteum was fabricated by using coaxial electrospinning technology with decellularized porcine small intestinal submucosa (SIS) as the shell and polycaprolactone (PCL) as the core. In vitro, the effects of the biomimetic periosteum on Schwann cells, vascular endothelial cells, and bone marrow mesenchymal stem cells were detected by a scratch test, an EdU, a tube-forming test, and an osteogenesis test. In vivo, we used HE staining to evaluate the effect of the biomimetic periosteum on bone regeneration. Results: In vitro experiments showed that the biomimetic periosteum could significantly promote the formation of angiogenesis, osteogenesis, and repaired Schwann cells (SCs). In vivo experiments showed that the biomimetic periosteum could promote the repair of bone defects. Conclusions: The biomimetic periosteum could simulate the structural function of the periosteum and promote bone repair. This strategy may provide a promising method for the clinical treatment of skull bone defects. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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16 pages, 6624 KiB  
Article
Calvaria Critical Size Defects Regeneration Using Collagen Membranes to Assess the Osteopromotive Principle: An Animal Study
by Vinícius Ferreira Bizelli, Edith Umasi Ramos, Allice Santos Cruz Veras, Giovana Rampazzo Teixeira, Leonardo P. Faverani and Ana Paula Farnezi Bassi
Membranes 2022, 12(5), 461; https://doi.org/10.3390/membranes12050461 - 24 Apr 2022
Cited by 8 | Viewed by 1785
Abstract
Guided bone regeneration (GBR) is a common practice in implantology, and it is necessary to use membranes in this process. The present study aimed to evaluate the osteopromotive principle of two porcine collagen membranes in critical-size defects at rats calvaria. Ninety-six Albinus Wistar [...] Read more.
Guided bone regeneration (GBR) is a common practice in implantology, and it is necessary to use membranes in this process. The present study aimed to evaluate the osteopromotive principle of two porcine collagen membranes in critical-size defects at rats calvaria. Ninety-six Albinus Wistar rats were divided into BG (positive control), JS, CS, and CG (negative control) groups and were sacrificed at 7, 15, 30, and 60 days postoperatively. The samples were assessed by histological, histometric, immunohistochemical, and microtomographic analyses. More intense inflammatory profile was seen in the JS and CS groups (p < 0.05). At 60 days, the JS group showed a satisfactory osteopromotive behavior compared to BG (p = 0.193), while CS did not demonstrate the capacity to promote bone formation. At the immunohistochemical analysis, the CS showed mild labeling for osteocalcin (OC) and osteopontin (OP), the JS demonstrated mild to moderate for OC and OP and the BG demonstrated moderate to intense for OC and OP. The tridimensional analysis found the lowest average for the total volume of newly formed bone in the CS (84,901 mm2), compared to the BG (319,834 mm2) (p < 0.05). We conclude that the different thicknesses and treatment techniques of each membrane may interfere with its biological behavior. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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16 pages, 1945 KiB  
Article
The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes
by Barbara Gawdzik, Paweł Kowalczyk, Dominik Koszelewski, Anna Brodzka, Joanna Masternak, Karol Kramkowski, Aleksandra Wypych and Ryszard Ostaszewski
Membranes 2022, 12(2), 238; https://doi.org/10.3390/membranes12020238 - 18 Feb 2022
Cited by 8 | Viewed by 1627
Abstract
Herein, we present biological studies on 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now, DHPMs have not been tested for biological activity against pathogenic E. coli strains. We tested 16 newly synthesized DHPMs as antimicrobial agents on [...] Read more.
Herein, we present biological studies on 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now, DHPMs have not been tested for biological activity against pathogenic E. coli strains. We tested 16 newly synthesized DHPMs as antimicrobial agents on model E. coli strains (K12 and R2–R4). Preliminary cellular studies using MIC and MBC tests and digestion of Fpg after modification of bacterial DNA suggest that these compounds may have greater potential as antibacterial agents than typically used antibiotics, such as ciprofloxacin (ci), bleomycin (b) and cloxacillin (cl). The described compounds are highly specific for pathogenic E. coli strains based on the model strains used and may be engaged in the future as new substitutes for commonly used antibiotics in clinical and nosocomial infections in the pandemic era. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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Review

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21 pages, 3310 KiB  
Review
3D Printed and Bioprinted Membranes and Scaffolds for the Periodontal Tissue Regeneration: A Narrative Review
by Irina-Georgeta Sufaru, Georgiana Macovei, Simona Stoleriu, Maria-Alexandra Martu, Ionut Luchian, Diana-Cristala Kappenberg-Nitescu and Sorina Mihaela Solomon
Membranes 2022, 12(9), 902; https://doi.org/10.3390/membranes12090902 - 19 Sep 2022
Cited by 16 | Viewed by 3426
Abstract
Numerous technologies and materials were developed with the aim of repairing and reconstructing the tissue loss in patients with periodontitis. Periodontal guided bone regeneration (GBR) and guided tissue regeneration (GTR) involves the use of a membrane which prevents epithelial cell migration, and helps [...] Read more.
Numerous technologies and materials were developed with the aim of repairing and reconstructing the tissue loss in patients with periodontitis. Periodontal guided bone regeneration (GBR) and guided tissue regeneration (GTR) involves the use of a membrane which prevents epithelial cell migration, and helps to maintain the space, creating a protected area in which tissue regeneration is favored. Over the time, manufacturing procedures of such barrier membranes followed important improvements. Three-dimensional (3D) printing technology has led to major innovations in periodontal regeneration methods, using technologies such as inkjet printing, light-assisted 3D printing or micro-extrusion. Besides the 3D printing of monophasic and multi-phasic scaffolds, bioprinting and tissue engineering have emerged as innovative technologies which can change the way we see GTR and GBR. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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14 pages, 3089 KiB  
Review
The Use of Biocompatible Membranes in Oral Surgery: The Past, Present & Future Directions. A Narrative Review
by Ioannis Kormas, Alessandro Pedercini, Hatem Alassy and Larry F. Wolff
Membranes 2022, 12(9), 841; https://doi.org/10.3390/membranes12090841 - 29 Aug 2022
Cited by 4 | Viewed by 3666
Abstract
The use of biocompatible membranes in periodontal and oral surgery is an important part of regeneration. Over the years, several different membranes have been developed, ranging from non-resorbable membranes that have to be removed in a separate procedure, to collagen membranes that completely [...] Read more.
The use of biocompatible membranes in periodontal and oral surgery is an important part of regeneration. Over the years, several different membranes have been developed, ranging from non-resorbable membranes that have to be removed in a separate procedure, to collagen membranes that completely resorb on their own, thus avoiding the need for a second surgery. Autogenous membranes are becoming increasingly popular in more recent years. These membranes can be used with a great variety of techniques in the four main hard tissue regenerative procedures: guided tissue regeneration, alveolar ridge preservation, guided bone regeneration and sinus floor augmentation. A review of the literature was conducted in order to identify the most commonly used membranes in clinical practice, as well as the most promising ones for regeneration procedures in the future. The information provided in this review may serve as a guide to clinicians, in order to select the most applicable membrane for the clinical case treated as the correct choice of materials may be critical in the procedure’s success. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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28 pages, 1612 KiB  
Review
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair
by Dongxue Wang, Hong Cao, Weizhong Hua, Lu Gao, Yu Yuan, Xuchang Zhou and Zhipeng Zeng
Membranes 2022, 12(7), 716; https://doi.org/10.3390/membranes12070716 - 19 Jul 2022
Cited by 14 | Viewed by 3667
Abstract
The repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes, with [...] Read more.
The repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes, with hydrogels, scaffolds, and other bioactive materials has made great progress, exhibiting a good potential for bone regeneration. Recent studies have found that miRNAs, proteins, and other cargo loaded in EVs are key factors in promoting osteogenesis and angiogenesis. In BTE, the expression profile of the intrinsic cargo of EVs can be changed by modifying the gene expression of MSCs to obtain EVs with enhanced osteogenic activity and ultimately enhance the osteoinductive ability of bone graft materials. However, the current research on MSC-EVs for repairing bone defects is still in its infancy, and the underlying mechanism remains unclear. Therefore, in this review, the effect of bioactive materials such as hydrogels and scaffolds combined with MSC-EVs in repairing bone defects is summarized, and the mechanism of MSC-EVs promoting bone defect repair by delivering active molecules such as internal miRNAs is further elucidated, which provides a theoretical basis and reference for the clinical application of MSC-EVs in repairing bone defects. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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16 pages, 2569 KiB  
Review
Barrier Membrane in Regenerative Therapy: A Narrative Review
by Muhammad Syafiq Alauddin, Nur Ayman Abdul Hayei, Muhammad Annurdin Sabarudin and Nor Haliza Mat Baharin
Membranes 2022, 12(5), 444; https://doi.org/10.3390/membranes12050444 - 20 Apr 2022
Cited by 23 | Viewed by 7088
Abstract
Guided bone and tissue regeneration remains an integral treatment modality to regenerate bone surrounding teeth and dental implants. Barrier membranes have been developed and produced commercially to allow space for bone regeneration and prevent the migration of unwanted cells. Ideal membrane properties, including [...] Read more.
Guided bone and tissue regeneration remains an integral treatment modality to regenerate bone surrounding teeth and dental implants. Barrier membranes have been developed and produced commercially to allow space for bone regeneration and prevent the migration of unwanted cells. Ideal membrane properties, including biocompatibility, sufficient structural integrity and suitable shelf life with easy clinical application, are important to ensure good clinical regenerative outcomes. Membranes have various types, and their clinical application depends on the origin, material, structure and properties. This narrative review aims to describe the currently available barrier membranes in terms of history, main features, types, indication and clinical application and classify them into various groups. Various membranes, including those which are resorbable and non-resorbable, synthetic, added with growth factors and composed of modern materials, such as high-grade polymer (Polyetheretherketone), are explored in this review. Full article
(This article belongs to the Special Issue Biocompatible Membranes for Bone Regeneration)
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