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Membranes
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Ion Channels in Membranes
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Ion Channels in Membranes

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".

Deadline for manuscript submissions: closed (10 October 2022) | Viewed by 6448

Special Issue Editors

Prof. Dr. Annarosa Arcangeli

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Guest Editor
Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, 50134 Firenze, Italy
Interests: tumor biology; ion channels; tumor microenviroment; antibody engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Claudia Duranti

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, 50134 Firenze, Italy
Interests: cancer biology; antibody fragments; antibody engineering; ion channels; protein expression and purification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ion channels are a class of membrane proteins which, besides their well-recognized role in controlling cell excitability and ionic and fluid control, are emerging as particularly relevant in cancer and several pathological conditions. In particular, being mainly present on the plasma membrane of cancer cells, different types of ion channels can mediate interactions between tumor cells and the tumor microenvironment to drive different aspects of neoplastic progression (e.g., cell proliferation and survival, cell invasiveness and pro-angiogenetic programs). What is more, ion channels represent one of the few druggable molecular classes and are increasingly recognized as novel and valuable molecular targets for antineoplastic therapy.

We are pleased to invite you to contribute to the present Special Issue. It focuses on biological membranes, discussing in particular membrane proteins, trafficking and cell signaling and computational analysis, with particular regard to ion channels, e.g., cellular membrane structure, function and biomolecular organization and dynamics, fluidity and composition, model membranes and liposomes, membrane proteins, membrane traffic, receptors, channels and anchoring mechanisms, cellular signaling, cell morphology, membrane chromatography, membrane surface studies and ligand interactions.

This Special Issue aims to focus on ion channel interactions, ion channel and transporter roles in pathological conditions and their function on plasma membrane; moreover, we welcome papers related to membrane proteins regulating cell signaling and cell trafficking and would also give space to computational analysis papers and in silico studies focusing on drug interactions with ion channels and membrane proteins.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biomedical research, applied biology, physiology, medical proteomics.

We look forward to receiving your contributions.

Prof. Dr. Annarosa Arcangeli
Dr. Claudia Duranti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ion channels
  • transporters
  • biological membranes
  • cell signaling
  • membrane trafficking

Published Papers (4 papers)

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Research

19 pages, 386 KiB  
Article
Mathematical Analysis on Current–Voltage Relations via Classical Poisson–Nernst–Planck Systems with Nonzero Permanent Charges under Relaxed Electroneutrality Boundary Conditions
by Yiwei Wang, Lijun Zhang and Mingji Zhang
Membranes 2023, 13(2), 131; https://doi.org/10.3390/membranes13020131 - 19 Jan 2023
Viewed by 866
Abstract
We focus on a quasi-one-dimensional Poisson–Nernst–Planck model with small permanent charges for ionic flows of two oppositely charged ion species through an ion channel. Of particular interest is to examine the dynamics of ionic flows in terms of I–V (current–voltage) relations with boundary [...] Read more.
We focus on a quasi-one-dimensional Poisson–Nernst–Planck model with small permanent charges for ionic flows of two oppositely charged ion species through an ion channel. Of particular interest is to examine the dynamics of ionic flows in terms of I–V (current–voltage) relations with boundary layers due to the relaxation of neutral conditions on boundary concentrations. This is achieved by employing the regular perturbation analysis on the solutions established through geometric singular perturbation analysis. Rich dynamics are observed, particularly, the nonlinear interplays among different physical parameters are characterized. Critical potentials are identified, which play critical roles in the study of ionic flows and can be estimated experimentally. Numerical simulations are performed to further illustrate and provide more intuitive understandings of our analytical results. Full article
(This article belongs to the Special Issue Ion Channels in Membranes)
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14 pages, 904 KiB  
Article
Discovery of the Potentiator of the Pore-Forming Ability of Lantibiotic Nisin: Perspectives for Anticancer Therapy
by Dayana N. Chernyshova, Alexander A. Tyulin, Olga S. Ostroumova and Svetlana S. Efimova
Membranes 2022, 12(11), 1166; https://doi.org/10.3390/membranes12111166 - 20 Nov 2022
Cited by 6 | Viewed by 1382
Abstract
This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the threshold [...] Read more.
This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the threshold detergent concentration of nisin. An addition of nisin to DOPG- and TOCL-enriched bilayers caused the formation of well-defined ion pores of various conductances. The transmembrane macroscopic current increased with the second power of the lantibiotic aqueous concentration, suggesting that the dimer of nisin was at least involved in the formation of conductive subunit. The pore-forming ability of lantibiotic decreased in the series: DOPC/TOCL ≈ DOPE/TOCL >> DOPC/DOPG ≥ DOPE/DOPG. The preferential interaction of nisin to cardiolipin-enriched bilayers might explain its antitumor activity by pore-formation in mitochondrial membranes. Small natural molecules, phloretin and capsaicin, were found to potentiate the membrane activity of nisin in the TOCL-containing membranes. The effect was referred to as changes in the membrane boundary potential at the adsorption of small molecules. We concluded that the compounds diminishing the membrane boundary potential should be considered as the potentiator of the nisin pore-forming ability that can be used to develop innovative formulations for anticancer therapy. Full article
(This article belongs to the Special Issue Ion Channels in Membranes)
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11 pages, 1986 KiB  
Article
The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models
by Ginevra Chioccioli Altadonna, Alberto Montalbano, Jessica Iorio, Andrea Becchetti, Annarosa Arcangeli and Claudia Duranti
Membranes 2022, 12(11), 1162; https://doi.org/10.3390/membranes12111162 - 18 Nov 2022
Cited by 1 | Viewed by 1471
Abstract
Ion channels are implicated in various diseases, including cancer, in which they modulate different aspects of cancer progression. In particular, potassium channels are often aberrantly expressed in cancers, a major example being provided by hERG1. The latter is generally complexed with β1 integrin [...] Read more.
Ion channels are implicated in various diseases, including cancer, in which they modulate different aspects of cancer progression. In particular, potassium channels are often aberrantly expressed in cancers, a major example being provided by hERG1. The latter is generally complexed with β1 integrin in tumour cells, and such a molecular complex represents a new druggable hub. The present study focuses on the characterization of the functional consequences of the interaction between hERG1 and β1 integrins on different substrates over time. To this purpose, we studied the interplay alteration on the plasma membrane through patch clamp techniques in a cellular model consisting of human embryonic kidney (HEK) cells stably transfected with hERG1 and in a cancer cell model consisting of SH-SY5Y neuroblastoma cells, endogenously expressing the channel. Cells were seeded on different substrates known to stimulate β1 integrins, such as fibronectin (FN) for HEK-hERG1 and laminin (LMN) for SH-SY5Y. In HEK cells stably overexpressing hERG1, we observed a hERG1 current density increase accompanied by Vrest hyperpolarization after cell seeding onto FN. Notably, a similar behaviour was shown by SH-SY5Y neuroblastoma cells plated onto LMN. Interestingly, we did not observe this phenomenon when plating the cells on substrates such as Bovine Serum Albumin (BSA) or Polylysine (PL), thus suggesting a crucial involvement of ECM proteins as well as of β1 integrin activation. Full article
(This article belongs to the Special Issue Ion Channels in Membranes)
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12 pages, 1805 KiB  
Article
Evidence for a Physiological Role of T-Type Ca Channels in Ventricular Cardiomyocytes of Adult Mice
by Jessica Marksteiner, Janine Ebner, Isabella Salzer, Elena Lilliu, Benjamin Hackl, Hannes Todt, Helmut Kubista, Seth Hallström, Xaver Koenig and Karlheinz Hilber
Membranes 2022, 12(6), 566; https://doi.org/10.3390/membranes12060566 - 28 May 2022
Cited by 1 | Viewed by 1940
Abstract
T-type Ca channels are strongly expressed and important in the developing heart. In the adult heart, these channels play a significant role in pacemaker tissues, but there is uncertainty about their presence and physiological relevance in the working myocardium. Here, we show that [...] Read more.
T-type Ca channels are strongly expressed and important in the developing heart. In the adult heart, these channels play a significant role in pacemaker tissues, but there is uncertainty about their presence and physiological relevance in the working myocardium. Here, we show that the T-type Ca channel isoforms Cav3.1 and Cav3.2 are expressed at a protein level in ventricular cardiomyocytes from healthy adult C57/BL6 mice. Myocytes isolated from adult wild-type and Cav3.2 KO mice showed considerable whole cell T-type Ca currents under beta-adrenergic stimulation with isoprenaline. We further show that the detectability of basal T-type Ca currents in murine wild-type cardiomyocytes depends on the applied experimental conditions. Together, these findings reveal the presence of functional T-type Ca channels in the membrane of ventricular myocytes. In addition, electrically evoked Ca release from the sarcoplasmic reticulum was significantly impaired in Cav3.2 KO compared to wild-type cardiomyocytes. Our work implies a physiological role of T-type Ca channels in the healthy adult murine ventricular working myocardium. Full article
(This article belongs to the Special Issue Ion Channels in Membranes)
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