Organelle Structure and Metabolism in Cancer Cells

Dear Colleagues,

An altered cellular metabolism has been recognized as one of the hallmarks of cancer. Cancer cells are known to divert flux through their metabolic pathways (glycolysis, pentose phosphate pathway, Krebs cycle, etc.) in order to increase macromolecule and organelle biosynthesis and maintain active cellular proliferation. Since metabolic alterations are closely linked to changes in organelle structure, both processes have been implicated in cellular changes in cancer initiation and progression, including oncogene-mediated transformation, epithelial-to-mesenchymal transition, cellular migration and invasion, cancer stem cell maintenance, and cellular interactions with the tumor microenvironment. In addition, metabolic alterations induce changes in intermediary metabolites, with some having oncogenic roles (succinate, fumarate, 2-hydroxyglutarate, etc.) that also contribute to the maintenance of metabolic changes in cancer cells.

This Special Issue welcomes submissions from diverse areas of cancer biology concerned with cancer cell alterations in organelle structure and metabolism, with the purpose of stimulating intriguing perspectives in the discipline.

Dr. Paola Maycotte
Dr. Álvaro Marín-Hernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cancer
• metabolism
• organelle
• mitochondria
• glycolysis
• oncometabolite