Gastrointestinal Microbiota Impacts Human Health and Disease 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1583

Special Issue Editor


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Guest Editor
1. The New Zealand Institute for Plant and Food Research Limited (PFR), Private Bag 11600, Palmerston North 4442, New Zealand
2. Riddet Institute, Massey University, Palmerston North 4442, New Zealand
Interests: human gastrointestinal microbiota; food-microbiota; health and disease
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our 2019 Special Issue "Gastrointestinal Microbiota Impacts Human Health and Disease".

A huge abundance and diversity of microorganisms that colonize different regions of the human gastrointestinal tract participate in a range of metabolic activities and influence many aspects of health and disease. They play an important role in maintaining immune homeostasis, assist in energy harvest from non-digestible dietary components through fermentation in the large intestine and generate many bioactive metabolites, such as short-chain fatty acids. Equally, dysbiosis is associated with a number of diseases including inflammatory bowel disease, diabetes mellitus, obesity and metabolic syndrome. Gut microbiome research has been revolutionised over the past decade through the development of culture-independent, high-throughput, next-generation DNA sequencing technology. We are developing a much better understanding of the composition of microbial communities of the healthy human gut, defining dominant members. The application of multiple omic technologies such metabolomics, proteomics, and transcriptomics has further enhanced our ability to decipher the function of the human gut microbiome including its interaction with the human host and impact on health. It is now well known that diet is one of the major influencers of both the short- and long-term composition of the human gut microbiome. Dietary manipulation of the gut microbiome therefore offers an attractive approach to achieve favourable health outcomes.

Dr. Pramod Gopal
Guest Editor

Manuscript Submission Information

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Keywords

  • gastrointestinal health
  • gut microbiome
  • gut–brain axis
  • probiotics
  • prebiotics
  • IBD
  • IBS
  • gut inflammation
  • gut comfort
  • gut function
  • SCFA
  • oligosaccharides

Published Papers (1 paper)

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Review

11 pages, 279 KiB  
Review
The Potential Role of Fecal Microbiota Transplant in the Reversal or Stabilization of Multiple Sclerosis Symptoms: A Literature Review on Efficacy and Safety
by Tooba Laeeq, Tahne Vongsavath, Kyaw Min Tun and Annie S. Hong
Microorganisms 2023, 11(12), 2840; https://doi.org/10.3390/microorganisms11122840 - 22 Nov 2023
Cited by 1 | Viewed by 1368
Abstract
Multiple sclerosis (MS) affects millions of people worldwide, and recent data have identified the potential role of the gut microbiome in inducing autoimmunity in MS patients. To investigate the potential of fecal microbiota transplant (FMT) as a treatment option for MS, we conducted [...] Read more.
Multiple sclerosis (MS) affects millions of people worldwide, and recent data have identified the potential role of the gut microbiome in inducing autoimmunity in MS patients. To investigate the potential of fecal microbiota transplant (FMT) as a treatment option for MS, we conducted a comprehensive literature search (PubMed/Medline, Embase, Web of Science, Scopus, and Cochrane) and identified five studies that involved 15 adult MS patients who received FMT for gastrointestinal symptoms. The primary outcome of this review was to assess the effect of FMT in reversing and improving motor symptoms in MS patients, while the secondary outcome was to evaluate the safety of FMT in this patient population. Our findings suggest that all 15 patients who received FMT experienced improved and reversed neurological symptoms secondary to MS. This improvement was sustained even in follow-up years, with no adverse effects observed. These results indicate that FMT may hold promise as a treatment option for MS, although further research is necessary to confirm these findings. Full article
(This article belongs to the Special Issue Gastrointestinal Microbiota Impacts Human Health and Disease 2.0)
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