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Microorganisms
Special Issues
Anti-inflammatory Property of Probiotics
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Anti-inflammatory Property of Probiotics

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 12995

Special Issue Editors

Dr. Bassam Abomoelak

E-Mail Website
Guest Editor
Pediatric Specialty Laboratory, Arnold Palmer Hospital, Orlando Health, Orlando, FL 32806, USA
Interests: probiotics; prebiotics industry; molecular biology of infectious diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hesham Ali El Enshasy

E-Mail Website
Guest Editor
Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 81310, Malaysia
Interests: probiotics; prebiotics industry; microbiome; microbial bioprocess; microbial bioactive metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Probiotics are used to treat chronic diseases, especially diseases that involve immune system modulation. The role of probiotics is observed in improving the conditions in some gastrointestinal diseases such as inflammatory bowel disease (IBD), Crohn’s disease (CD), and ulcerative colitis (UC). The mechanisms of such improvements remain largely speculative. In the adverse conditions of IBD, the host’s immune cells secrete excessive amounts of inflammatory substances, including cytokines and active oxides. Probiotic treatment has been proven to downregulate the expression of proinflammatory cytokines such as tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), and interferon gamma, inducible nitric oxide synthase, and matrix metalloproteinase activity in inflamed mucosa of active IBD or experimental UC. Data have confirmed that probiotic strains and cell-free supernatants reduce the expression of pro-inflammatory cytokines mediated by toll-like receptors. Probiotic supplementation appears to be potentially effective, and safe in patients with IBD, in both CD and UC. For this reason, further studies are required to understand the precise mechanisms by which probiotics affect these diseases and their precise role in anti-inflammatory effects. In addition, recent studies have focused on the modulation of gut microbiota as a promising strategy in IBD control. The scope of this Special Issue will cover the role of different probiotics in anti-inflammatory effects in animal and human subjects. Special emphasis will be on mechanistic pathways of disease control and remission. In addition, we welcome the development or discovery of novel probiotic strains of a potential anti-inflammatory effect on animals and humans. The Special Issue welcomes original research articles, reviews, and clinical trials. We look forward to receiving your contributions.

Dr. Bassam Abomoelak
Prof. Dr. Hesham Ali El Enshasy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • probiotics
  • gastrointestinal diseases
  • anti-inflammatory effects
  • cytokines
  • animal models
  • human

Published Papers (4 papers)

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Research

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15 pages, 4989 KiB  
Article
Amelioration of Murine Colitis by Attenuated Salmonella choleraesuis Encoding Interleukin-19
by Shih-Yao Chen, Chun-Ting Chu, Mei-Lin Yang, Jian-Da Lin, Chung-Teng Wang, Che-Hsin Lee, I-Chen Lin, Ai-Li Shiau, Pin Ling and Chao-Liang Wu
Microorganisms 2023, 11(6), 1530; https://doi.org/10.3390/microorganisms11061530 - 8 Jun 2023
Cited by 1 | Viewed by 1457
Abstract
The imbalance of mucosal immunity in the lower gastrointestinal tract can lead to chronic inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis. IBD is a chronic inflammatory disorder that causes small and/or large intestines ulceration. According to previous studies, recombinant interleukin [...] Read more.
The imbalance of mucosal immunity in the lower gastrointestinal tract can lead to chronic inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis. IBD is a chronic inflammatory disorder that causes small and/or large intestines ulceration. According to previous studies, recombinant interleukin (IL)-10 protein and genetically modified bacteria secreting IL-10 ameliorate dextran sulfate sodium (DSS)-induced colitis in mice. IL-19 is a transcriptional activator of IL-10 and can alter the balance of T helper 1 (Th)1/Th2 cells in favor of Th2. In this study, we aimed to investigate whether the expression of the murine IL-19 gene carried by Salmonella choleraesuis (S. choleraesuis) could ameliorate murine IBD. Our results showed that the attenuated S. choleraesuis could carry and express the IL-19 gene-containing plasmid for IBD gene therapy by reducing the mortality and clinical signs in DSS-induced acute colitis mice as compared to the untreated ones. We also found that IL-10 expression was induced in IL-19-treated colitis mice and prevented inflammatory infiltrates and proinflammatory cytokine expression in these mice. We suggest that S. choleraesuis encoding IL-19 provides a new strategy for treating IBD in the future. Full article
(This article belongs to the Special Issue Anti-inflammatory Property of Probiotics)
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Review

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22 pages, 709 KiB  
Review
Prebiotics in New-Born and Children’s Health
by Shanmugaprakasham Selvamani, Nidhi Kapoor, Arun Ajmera, Hesham Ali El Enshasy, Daniel Joe Dailin, Dalia Sukmawati, Mona Abomoelak, Muktiningsih Nurjayadi and Bassam Abomoelak
Microorganisms 2023, 11(10), 2453; https://doi.org/10.3390/microorganisms11102453 - 29 Sep 2023
Cited by 2 | Viewed by 1850
Abstract
At present, prebiotics, like probiotics, are receiving more attention as a promising tool for health maintenance. Many studies have recognized the role of prebiotics in preventing and treating various illnesses including metabolic disorders, gastrointestinal disorders, and allergies. Naturally, prebiotics are introduced to the [...] Read more.
At present, prebiotics, like probiotics, are receiving more attention as a promising tool for health maintenance. Many studies have recognized the role of prebiotics in preventing and treating various illnesses including metabolic disorders, gastrointestinal disorders, and allergies. Naturally, prebiotics are introduced to the human body in the first few hours of life as the mother breastfeeds the newborn. Prebiotic human milk oligosaccharides (HMOs) are the third largest constituent of human breastmilk. Studies have proven that HMOs modulate an infant’s microbial composition and assist in the development of the immune system. Due to some health conditions of the mother or beyond the recommended age for breastfeeding, infants are fed with formula. Few types of prebiotics have been incorporated into formula to yield similar beneficial impacts similar to breastfeeding. Synthetic HMOs have successfully mimicked the bifidogenic effects of breastmilk. However, studies on the effectiveness and safety of consumption of these synthetic HMOs are highly needed before massive commercial production. With the introduction of solid foods after breastfeeding or formula feeding, children are exposed to a range of prebiotics that contribute to further shaping and maturing their gut microbiomes and gastrointestinal function. Therefore, this review evaluates the functional role of prebiotic interventions in improving microbial compositions, allergies, and functional gastrointestinal disorders in children. Full article
(This article belongs to the Special Issue Anti-inflammatory Property of Probiotics)
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16 pages, 1513 KiB  
Review
Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases
by Raden Mohamad Rendy Ariezal Effendi, Muhammad Anshory, Handono Kalim, Reiva Farah Dwiyana, Oki Suwarsa, Luba M. Pardo, Tamar E. C. Nijsten and Hok Bing Thio
Microorganisms 2022, 10(12), 2382; https://doi.org/10.3390/microorganisms10122382 - 30 Nov 2022
Cited by 26 | Viewed by 6362
Abstract
Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and [...] Read more.
Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD). Akkermansia muciniphila (A. muciniphila) and Faecalibacterium prausnitzii (F. prausnitzii) are two different types of bacteria that play a significant part in this function. It has been established that Akkermansia and Faecalibacterium are abundant in normal populations and have protective benefits on digestive health while also enhancing the immune system, metabolism, and gut barrier of the host. They have the potential to be a therapeutic target in diseases connected to the microbiota, such as immunological disorders and cancer immunotherapy. There has not been a review of the anti-inflammatory effects of Akkermansia and Faecalibacterium, particularly in immunological diseases. In this review, we highlight the most recent scientific findings regarding A. muciniphila and F. prausnitzii as two significant gut microbiota for microbiome alterations and seek to provide cutting-edge insight in terms of microbiome-targeted therapies as promising preventive and therapeutic tools in immune-related diseases and cancer immunotherapy. Full article
(This article belongs to the Special Issue Anti-inflammatory Property of Probiotics)
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19 pages, 1598 KiB  
Review
Bioactive Compounds from Red Microalgae with Therapeutic and Nutritional Value
by Flora Tsvetanova and Dragomir Yankov
Microorganisms 2022, 10(11), 2290; https://doi.org/10.3390/microorganisms10112290 - 18 Nov 2022
Cited by 7 | Viewed by 2468
Abstract
Red microalgae represent a natural reservoir of beneficial substances with applications in different industrial sectors. They are rich in natural biomolecules known for their antihypertensive, antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and anticoagulant activities. Many red microalgae are a source of vitamins, minerals, photochemicals, [...] Read more.
Red microalgae represent a natural reservoir of beneficial substances with applications in different industrial sectors. They are rich in natural biomolecules known for their antihypertensive, antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and anticoagulant activities. Many red microalgae are a source of vitamins, minerals, photochemicals, polyunsaturated fatty acids, and a wide spectrum of polysaccharides. The content of their valuable compounds and their activities have turned red microalgae into cellular factories of special interest in food, nutraceutical, and pharmaceutical industries. Like all microalgae, the red ones are superior to traditional crops for the aims of biotechnology as they are renewable sources widely available in great quantities and are easy to culture. Moreover, some of the most studied red microalgae are generally recognized as safe. This review summarizes the valuable biochemicals from red microalgae and highlights their health and nutritional benefits. Full article
(This article belongs to the Special Issue Anti-inflammatory Property of Probiotics)
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