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Microorganisms
Special Issues
Gut Microbiota and Precise Modulation
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Gut Microbiota and Precise Modulation

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 834

Special Issue Editor

Dr. Yongjun Wei

E-Mail Website
Guest Editor
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
Interests: plant natural products; yeast; metabolic engineering; synthetic biology; environmental microbiota; gut microbiota; precise modulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gut microbiota plays a critical role in maintaining human health. Understanding an individual’s gut microbiota can provide insights into key taxonomic groups and potential diseases associated with the gut microbiota. Analyzing the gut microbiota of a cohort can help identify the distribution and variation of microbes related to human health. Probiotics can be used to modulate the gut microbiota, and studying the composition of probiotics in different individuals can not only reveal their health status but also provide information on which probiotics have colonized their gut microbiota. Based on this information, proper prebiotics can be supplemented to support the growth of personal probiotics, and specific probiotics can be provided to enhance the colonization of individual probiotics in the gut microbiota. To provide precise recommendations for personal gut microbiota modulation, further research and development are needed in the application of microbiome and synthetic probiotics.

Dr. Yongjun Wei
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • human health
  • keystone taxonomy
  • disease
  • probiotics
  • prebiotics
  • precise modulation

Published Papers (1 paper)

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Research

22 pages, 7000 KiB  
Article
Exploring Gut Microbiota Alterations with Trimethoprim-Sulfamethoxazole and Dexamethasone in a Humanized Microbiome Mouse Model
by George B. H. Green, Alexis N. Cox-Holmes, Olivia Backan, Olivia Valbak, Anna Claire E. Potier, Dongquan Chen, Casey D. Morrow, Christopher D. Willey and Braden C. McFarland
Microorganisms 2024, 12(5), 1015; https://doi.org/10.3390/microorganisms12051015 - 17 May 2024
Viewed by 540
Abstract
Along with the standard therapies for glioblastoma, patients are commonly prescribed trimethoprim-sulfamethoxazole (TMP-SMX) and dexamethasone for preventing infections and reducing cerebral edema, respectively. Because the gut microbiota impacts the efficacy of cancer therapies, it is important to understand how these medications impact the [...] Read more.
Along with the standard therapies for glioblastoma, patients are commonly prescribed trimethoprim-sulfamethoxazole (TMP-SMX) and dexamethasone for preventing infections and reducing cerebral edema, respectively. Because the gut microbiota impacts the efficacy of cancer therapies, it is important to understand how these medications impact the gut microbiota of patients. Using mice that have been colonized with human microbiota, this study sought to examine how TMP-SMX and dexamethasone affect the gut microbiome. Two lines of humanized microbiota (HuM) Rag1−/− mice, HuM1Rag and HuM2Rag, were treated with either TMP-SMX or dexamethasone via oral gavage once a day for a week. Fecal samples were collected pre-treatment (pre-txt), one week after treatment initiation (1 wk post txt), and three weeks post-treatment (3 wk post txt), and bacterial DNA was analyzed using 16S rRNA-sequencing. The HuM1Rag mice treated with TMP-SMX had significant shifts in alpha diversity, beta diversity, and functional pathways at all time points, whereas in the HuM2Rag mice, it resulted in minimal changes in the microbiome. Likewise, dexamethasone treatment resulted in significant changes in the microbiome of the HuM1Rag mice, whereas the microbiome of the HuM2Rag mice was mostly unaffected. The results of our study show that routine medications used during glioblastoma treatment can perturb gut microbiota, with some microbiome compositions being more sensitive than others, and these treatments could potentially affect the overall efficacy of standard-of-care therapy. Full article
(This article belongs to the Special Issue Gut Microbiota and Precise Modulation)
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