Plant Extracts and Antimicrobials, Second Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1157

Special Issue Editors


E-Mail Website
Guest Editor
Pharmacy Department, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy
Interests: medicinal plants and fungi; dermatophytes; microorganisms; human pathogenic fungi and bacteria; antimicrobials; biological assays
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06121 Perugia, Italy
Interests: botany; vegatation science; biological activities; dermatophyte; plants; fungal extracts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Plant Extracts and Antimicrobials” (https://www.mdpi.com/si/114873).

Microbial pathogenicity and other infectious diseases have been controlled by the use of commercially available antimicrobial drugs in recent years. Antimicrobial drugs have, however, been overused and misused in the general population, which led to an increase in drug resistance rates among several microorganisms. Hence, in recent years, antimicrobial drug resistance has been recognized as a major global health threat. Medicinal plants are an important source of pharmacologically active secondary compounds such as coumarins, flavonoids, phenolics, alkaloids, terpenoids, tannins, lectin, polypeptides, and polyacetylenes. Numerous articles reporting on the antimicrobial activity of plant extracts have been published. Industrial hemp is one of many examples; recent studies have shown that inflorescence water extract and essential oils from this plant have antifungal activity against dermatophytes (Orlando et al. 2021). In this Special Issue dedicated to “Plant Extracts and Antimicrobials”, research papers and reviews about the research on new antimicrobial plant extracts or molecules, at a laboratory scale or at a pilot level, are welcome. The alternative use of plant extracts or compounds in food, beverage, supplements, and cosmetics can also be part of this Special Issue.

Topics that are particularly of interest include but are not limited to the following:

  • Production of plant compounds with antimicrobial properties;
  • Industrial applications and scaling up;
  • Methods to increase the active compounds’ yield (e.g., bioelicitation);
  • Product extraction and characterization;
  • Plant tissue culture in vitro and biochemical pathways;
  • Bioactivity of wild specimens versus cultivated specimens;
  • In vitro and in vivo tests;
  • Microbial species and strain screening.

Dr. Paola Angelini
Dr. Giancarlo Angeles Flores
Prof. Dr. Roberto Venanzoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterials
  • antifungals
  • antivirals
  • bioactive compounds
  • biofilms
  • dermatophytes
  • drug resistance
  • food
  • beverages and supplements
  • pathogenics
  • mode of action
  • plant extracts
  • screening
  • spices

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 6148 KiB  
Article
Syringaldehyde Exhibits Antibacterial and Antioxidant Activities against Mycobacterium marinum Infection
by Da Wen, Chaoqun Meng, Yazhi Feng, Lin Shen, Yiyao Liu, Wei Sun, Guangxin Chen and Changxin Wu
Microorganisms 2024, 12(2), 348; https://doi.org/10.3390/microorganisms12020348 - 7 Feb 2024
Viewed by 831
Abstract
Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb), which has a unique resistance to many antimicrobial agents. TB has emerged as a significant worldwide health issue because of the rise of multidrug-resistant strains causing drug-resistant TB (DR-TB). As a [...] Read more.
Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb), which has a unique resistance to many antimicrobial agents. TB has emerged as a significant worldwide health issue because of the rise of multidrug-resistant strains causing drug-resistant TB (DR-TB). As a result, the development of new drugs or effective strategies is crucial for patients with TB. Mycobacterium marinum (Mm) and Mtb are both species of mycobacteria. In zebrafish, Mm proliferates and forms chronic granulomatous infections, which are similar to Mtb infections in lung tissue. Syringaldehyde (SA) is a member of the phenolic aldehyde family found in various plants. Here, we investigated its antioxidative and antibacterial properties in Mm-infected cells and zebrafish. Our results demonstrated that SA inhibits Mm-infected pulmonary epithelial cells and inhibits the proliferation of Mm in Mm-infected zebrafish, suggesting that SA provides an antibacterial effect during Mm infection. Further study demonstrated that supplementation with SA inhibits the production of malondialdehyde (MDA) and reactive oxygen species (ROS) and increases the levels of reduced glutathione (GSH) in Mm-infection-induced macrophages. SA inhibits the levels of MDA in Mm-infected zebrafish, suggesting that SA exerts antioxidative effects in vivo. Additionally, we found that SA promotes the expression of NRF2/HO-1/NQO-1 and the activation of the AMPK-α1/AKT/GSK-3β signaling pathway. In summary, our data demonstrated that SA exerts antioxidative and antibacterial effects during Mm infection both in vivo and in vitro and that the antioxidative effects of SA may be due to the regulation of NRF2/HO-1/NQO-1 and the AMPK-α1/AKT/GSK-3β signaling pathway. Full article
(This article belongs to the Special Issue Plant Extracts and Antimicrobials, Second Edition)
Show Figures

Figure 1

Back to TopTop