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Microorganisms
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Mechanisms of Mycobacteria Drug Resistance and Impact for Innovative Antimycobacterial...
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Mechanisms of Mycobacteria Drug Resistance and Impact for Innovative Antimycobacterial Drug Development

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1289

Special Issue Editor

Dr. Véronique Fontaine

E-Mail Website
Guest Editor
Research in Drug Development, Faculty of Pharmacy, Université libre de Bruxelles (ULB), 1050 Brussels, Belgium
Interests: Mycobacterium; tuberculosis; drug resistance and tolerance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tuberculosis (TB) caused mainly by Mycobacterium tuberculosis, which represents the second largest cause of death, after COVID-19, from a single infectious agent. The current treatment regimen lasts months and uses four anti-TB drugs. Furthermore, the emergence of multidrug-resistant strains is a major concern.

Infected patients can either present with TB or be latently infected. M. tuberculosis can be detected either intracellularly, in the macrophage, granuloma, or extracellularly, in necrotic lesions.

Due to metabolic changes, the ability of M. tuberculosis to resist or adapt and persist to its stress environment is one of the main reasons that explains the difficulty of achieving its eradication and cure.

This Special Issue will explore mycobacterial drug resistance and tolerance mechanisms and highlight new anti-TB target candidates.

Dr. Véronique Fontaine
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mycobacterium
  • drug resistance
  • drug tolerance
  • metabolic adaptation
  • biofilm
  • anti-TB drug development
  • anti-TB drug target
  • mycobacterial cell wall
  • efflux pumps

Published Papers (1 paper)

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Research

12 pages, 1446 KiB  
Article
Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes
by Dong Yang, Yanfang Zhang, Ibrahima Sory Sow, Hongping Liang, Naïma El Manssouri, Michel Gelbcke, Lina Dong, Guangxin Chen, François Dufrasne, Véronique Fontaine and Rongshan Li
Microorganisms 2023, 11(10), 2611; https://doi.org/10.3390/microorganisms11102611 - 23 Oct 2023
Viewed by 1040
Abstract
Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) [...] Read more.
Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20–100 µM of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilm development. HA10Fe2, HA12Fe2 and HA12FeCl could even attack pre-formed Pseudomonas aeruginosa biofilms at higher concentrations (around 300 µM). The phthiocerol dimycocerosate (PDIM)-deficient Mycobacterium tuberculosis H37Ra was more sensitive to the ion complexes of HA compared to other mycobacterial strains. Furthermore, HA10FeCl could increase the susceptibility of Mycobacterium bovis BCG to vancomycin. Proteomic profiles showed that the potential targets of HA10FeCl were mainly related to mycobacterial stress adaptation, involving cell wall lipid biosynthesis, drug resistance and tolerance and siderophore metabolism. This study provides new insights regarding the antimycobacterial activities of HA and their complexes, especially about their potential anti-biofilm activities. Full article
(This article belongs to the Special Issue Mechanisms of Mycobacteria Drug Resistance and Impact for Innovative Antimycobacterial Drug Development)
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