Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Feature Papers in Gut Microbiota and Disease
share announcement

Feature Papers in Gut Microbiota and Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 30562

Special Issue Editor

Prof. Dr. Konstantinos Triantafyllou

E-Mail Website
Guest Editor
Hepatogastroenterology, 2nd Department of Internal Medicine-Propaedeutic, Attikon University General Hospital, Medical School, Athens University, Athens, Greece
Interests: gastroenterology; microbiome; inflammatory bowel disease; gastrointestinal diseases

Special Issue Information

Dear Colleagues,

The Special Issue "Feature Papers in Gut Microbiota and Disease" aims to provide an overview of research regarding the gut microbiota, and we invite colleagues to contribute original research articles or reviews related to their research. Topics can include, but are not limited to:

  • The structure and function of the microbiota;
  • Microbial community genetics, transcriptomics, proteomics, and metabolomics;
  • Interaction within the microbiota;
  • Metabolic interaction with the host;
  • Inflammatory diseases;
  • Interaction with the immune system;
  • Microbial biodegradation of nutrients and xenobiotics;
  • Microbial ecology;
  • Microbial functions in the different habitats within the gut;
  • Metabolic flux analysis;
  • The analysis of functionalities by stable isotope probing (DNA, RNA, and protein);
  • Model systems for studying microbiome biology;
  • Novel technologies for the analysis of the structure and function of the microbiota.

Prof. Dr. Konstantinos Triantafyllou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

10 pages, 6108 KiB  
Article
Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
by Evripidis Rizos, Emmanouel Pyleris, Mark Pimentel, Konstantinos Triantafyllou and Evangelos J. Giamarellos-Bourboulis
Microorganisms 2022, 10(5), 960; https://doi.org/10.3390/microorganisms10050960 - 2 May 2022
Cited by 5 | Viewed by 2547
Abstract
Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed in 224 patients. Quantitative cultures [...] Read more.
Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed in 224 patients. Quantitative cultures of aerobic species were performed, concentrations of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured, and loads of Escherichia coli, Klebsiella pneumoniae, Methanobevibacter smithii, and Aeromonas spp. were detected via real-time PCR in the duodenal fluid. Analysis showed that the odds ratio (OR) for elevated IL-1β levels was 2.61 (1.06–6.43, p = 0.037) among patients with SIBO compared to patients without SIBO, while there was no significant difference at elevated IL-6 and TNF-α levels between patients with and without SIBO, using ≥10³ cfu/mL as a cut-off. The presence of all three elevated cytokine levels has OR 3.47 (1.06–11.34, p = 0.030) among patients with SIBO. Klebsiella pneumoniae detection was positively related with IL-6 and TNF-α levels, when Methanobevibacter smithii was positively related with IL-1β levels. The presence of SIBO is associated with elevated IL-1β levels in the duodenal fluid. There is a high prevalence of all three proinflammatory cytokine levels elevated (IL-1β, IL-6, and TNF-α) in the duodenal fluid among patients with SIBO. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

17 pages, 2866 KiB  
Article
Selection and Optimization of High-Yielding DNA Isolation Protocol for Quantitative Analyses of Methanogenic Archaea
by Agata Anna Cisek, Iwona Bąk, Ilona Stefańska and Marian Binek
Microorganisms 2022, 10(3), 523; https://doi.org/10.3390/microorganisms10030523 - 28 Feb 2022
Cited by 5 | Viewed by 2443
Abstract
Methanogenic archaea are a functionally important component of the intestinal microbiota of humans and animals, participating in the utilization of detrimental hydrogen produced during gut fermentation. Despite this, archaeal DNA has rarely been found in intestinal microbiome analyses, which prompts the need to [...] Read more.
Methanogenic archaea are a functionally important component of the intestinal microbiota of humans and animals, participating in the utilization of detrimental hydrogen produced during gut fermentation. Despite this, archaeal DNA has rarely been found in intestinal microbiome analyses, which prompts the need to optimize detecting procedures of these microorganisms, including the DNA isolation step. Three commercially available kits for DNA isolation and one extra purification kit that removes PCR inhibitors were evaluated on chicken droppings. In addition, different variants of mechanical lysis and a double elution were tested to ensure the maximum efficiency of DNA isolation from archaea as well as bacteria. A quantitative real-time PCR was used to monitor the optimization progress. As a result, the combination of the selected Genomic Mini AX Bacteria+ kit with a 2-min-long sonication by ultrasonic probe and enzymatic pretreatment gave excellent extraction efficiency rates for DNA of methanogenic archaea (an approximate 50-fold increase compared to the standard enzymatic lysis described by the producer) and, at the same time, provided optimal protection of DNA extracted from bacteria susceptible to enzymatic lysis. The presented results indicate that the optimized protocol allows for highly efficient extraction of total DNA, which is well-suited for quantitative microbial analyses by real-time PCR. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 829 KiB  
Review
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy
by Andrea García-Llorca and Georgios Kararigas
Microorganisms 2023, 11(2), 447; https://doi.org/10.3390/microorganisms11020447 - 10 Feb 2023
Cited by 3 | Viewed by 2169
Abstract
The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults [...] Read more.
The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

14 pages, 499 KiB  
Review
Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis
by Konstantinos Tsamakis, Sofia Galinaki, Evangelos Alevyzakis, Ioannis Hortis, Dimitrios Tsiptsios, Evangelia Kollintza, Stylianos Kympouropoulos, Konstantinos Triantafyllou, Nikolaos Smyrnis and Emmanouil Rizos
Microorganisms 2022, 10(6), 1121; https://doi.org/10.3390/microorganisms10061121 - 29 May 2022
Cited by 11 | Viewed by 3368
Abstract
There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between [...] Read more.
There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

12 pages, 1167 KiB  
Review
A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!
by Arezina Kasti, Konstantinos Petsis, Sophia Lambrinou, Konstantinos Katsas, Maroulla Nikolaki, Ioannis S. Papanikolaou, Erifili Hatziagelaki and Konstantinos Triantafyllou
Microorganisms 2022, 10(4), 751; https://doi.org/10.3390/microorganisms10040751 - 30 Mar 2022
Cited by 9 | Viewed by 5360
Abstract
Among other factors, food intolerance is cardinal in triggering irritable bowel syndrome (IBS) symptoms in a significant percentage of patients. As a result, specific dietary patterns are the first-line therapeutic approach. The low-FODMAP diet (LFD) is gaining ground as the most well-documented diet [...] Read more.
Among other factors, food intolerance is cardinal in triggering irritable bowel syndrome (IBS) symptoms in a significant percentage of patients. As a result, specific dietary patterns are the first-line therapeutic approach. The low-FODMAP diet (LFD) is gaining ground as the most well-documented diet intervention that significantly reduces IBS symptoms. Though the LFD improves symptoms, the diet’s impact on intestinal low-grade inflammation, one of the cardinal mechanisms contributing to symptom development, remains doubtful. On the other hand, the Mediterranean diet (MedDiet) is recommended for chronic low-grade inflammation-related diseases because of its anti-inflammatory properties, derived predominantly from olive oil and phenolic compounds. Thus far, the role of a modified LFD, enriched with the MedDiet’s anti-inflammatory components, has not been evaluated in IBS patients. This review aims to examine the hypothesis of a potential combination of the immunomodulatory effects of the MedDiet with the LFD to improve IBS symptoms. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

12 pages, 602 KiB  
Review
The Effects of Stevia Consumption on Gut Bacteria: Friend or Foe?
by Arezina N. Kasti, Maroulla D. Nikolaki, Kalliopi D. Synodinou, Konstantinos N. Katsas, Konstantinos Petsis, Sophia Lambrinou, Ioannis A. Pyrousis and Konstantinos Triantafyllou
Microorganisms 2022, 10(4), 744; https://doi.org/10.3390/microorganisms10040744 - 30 Mar 2022
Cited by 15 | Viewed by 13936
Abstract
Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the [...] Read more.
Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the vascular wall, reduces blood pressure levels and hepatic steatosis, stabilizes the atherosclerotic plaque, and ameliorates liver and kidney damage. The metabolism of steviol glycosides is dependent upon gut microbiota, which breaks down glycosides into steviol that can be absorbed by the host. In this review, we elucidated the effects of stevia’s consumption on the host’s gut microbiota. Due to the lack of randomized clinical trials in humans, we included in vitro using certain microbial strains and in vivo in laboratory animal studies. Results indicated that stevia consumption has a potential benefit on the microbiome’s alpha diversity. Alterations in the colonic microenvironment may depend on the amount and frequency of stevia intake, as well as on the simultaneous consumption of other dietary components. The anti-inflammatory properties of stevioside were confirmed in vitro by decreasing TNF-α, IL-1β, IL-6 synthesis and inhibiting of NF-κB transcription factor, and in vivo by inhibiting NF-κB and MAPK in laboratory animals. Full article
(This article belongs to the Special Issue Feature Papers in Gut Microbiota and Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop