Innate Antimicrobial Immunity and Virus–Bacteria Interactions

Dear Colleagues,

The outcome of microbial infections depends on the interplay between host factors and the environment. Host factors, like the activation of the type I-III interferon (IFN) innate immune responses, are involved in tuning antimicrobial and inflammation responses as well as emerging negative modifiers of many viral infections. However, the role of these antiviral genes in the context of bacterial infections has been not well characterized. Of note, bacteria and viruses often occupy the same niches, but their potential roles in promoting wellness or disease states as well as in modifying the innate immunity response has only recently gained traction. Hence, the scope of this Special Issue will be as follows:  I) to delineate the presence and demonstrate the clinical value of the IFN-signature and innate immunity in different bacteria or viral infections; ii) to better understand the dynamics between bacteria and viruses; and iii) to ascertain whether the virus–bacteria coinfection compromises the IFN and inflammatory response.

This Special Issue will provide some key examples of the importance of the innate immune response in the control of microbial infections as well as how virus–bacteria interactions can impact the infection process and the activation of host defenses.

Dr. Carolina Scagnolari
Guest Editor

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