molecules-logo

Journal Browser

Journal Browser

Second Edition of Medicinal Chemistry in Asia

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 21122

Special Issue Editors


E-Mail Website
Guest Editor
Key Lab in Health Science and Technology, Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Interests: diabetes; hyperlipidemia; obesity; Inflammation; molecular pharmacology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
Interests: pharmaceutics; nanomedicine; medicinal chemistry; drug delivery; biomaterials; anticancer drugs; cancer therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is entitled “Second Edition of Medicinal Chemistry in Asia”. In Asia, many research groups, both from industry and academia, are working on medicinal chemistry topics that cover almost all therapeutic fields, ranging from anticancer and antimicrobial agents to compounds potentially active in diabetes, hyperlipidemia, obesity, non-alcoholic fatty liver diseases, cardiovascular diseases, nervous system disease, gastrointestinal disorders, and immune and inflammatory dysfunction. The results obtained—often proving to be very important and recognized all over the world—are derived from the close collaboration of experts in different areas, such as computational chemistry, organic chemistry, nanomedicine, cellular and molecular biology, biochemistry, and pharmacology.

Scientists from Asia are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules, which reports on the design, synthesis, and evaluation of potentially active compounds and action mechanisms in the different subjects of medicinal chemistry.

Dr. Wei-dong Xie
Dr. Xiaowei Zeng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glucose and lipid-regulating drugs
  • immunomodulatory and anti-inflammatory drugs
  • cardiovascular protective drugs
  • anticancer and antimicrobial drugs
  • gastrointestinal regulating drugs
  • nanomedicine and drug delivery system

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 3022 KiB  
Article
Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets
by Zhiyi Yuan, Xi Lu, Fan Lei, Hong Sun, Jingfei Jiang, Dongming Xing and Lijun Du
Molecules 2023, 28(12), 4641; https://doi.org/10.3390/molecules28124641 - 8 Jun 2023
Cited by 4 | Viewed by 2040
Abstract
p-coumaric acid (p-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment [...] Read more.
p-coumaric acid (p-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of p-CA on the down-regulation of accumulated lipids in vivo and in vitro. p-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, p-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, p-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, p-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver. Full article
(This article belongs to the Special Issue Second Edition of Medicinal Chemistry in Asia)
Show Figures

Figure 1

Review

Jump to: Research

28 pages, 1000 KiB  
Review
Research Progress on Skin Aging and Active Ingredients
by Xin He, Fang Wan, Wenhui Su and Weidong Xie
Molecules 2023, 28(14), 5556; https://doi.org/10.3390/molecules28145556 - 20 Jul 2023
Cited by 21 | Viewed by 17726
Abstract
With the advancement of living standards in modern society and the emergence of an aging population, an increasing number of people are becoming interested in the topic of aging and anti-aging. An important feature of aging is skin aging, and women are particularly [...] Read more.
With the advancement of living standards in modern society and the emergence of an aging population, an increasing number of people are becoming interested in the topic of aging and anti-aging. An important feature of aging is skin aging, and women are particularly concerned about skin aging. In the field of cosmetics, the market share of anti-aging products is increasing year by year. This article reviews the research and development progress of skin aging and related active compounds both domestically and internationally in recent years. The results show that, in terms of the research on skin aging, the popular theories mainly include free radicals and oxidative stress theory, inflammation theory, photoaging theory, and nonenzymatic glycosyl chemistry theory. In terms of research on the active ingredients with anti-aging activities in the skin, there are numerous reports on related products in clinical studies on human subjects, animal experiments, and experimental studies on cell cultures, with a variety of types. Most of the compounds against skin aging are sourced from natural products and their action mechanisms are mainly related to scavenging oxygen free radicals and enhancing antioxidant defenses. This review provides important references for the future research of skin aging and the development of related products. Although there is a great progress in skin aging including related active ingredients, ideal compounds or products are still lacking and need to be further validated. New mechanisms of skin aging, new active ingredients sourced from natural and artificial products, and new pharmaceutical forms including further clinical validations should be further investigated in the future. Full article
(This article belongs to the Special Issue Second Edition of Medicinal Chemistry in Asia)
Show Figures

Figure 1

Back to TopTop