NSAIDs and Their Derivatives in Medicinal Chemistry

Dear Colleagues,

While non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for reducing pain, fever, and inflammation, their effects on several other diseases (such as viral infections and some cancers , etc.) have also been demonstrated. However, their prolonged use is usually associated with several adverse events—mainly gastric ulcers or cardiovascular side effects. Over the past several years, interest in NSAIDs has flourished again, leading to the discovery of nitric oxide (NO)-, phospho- or hydrogen sulfide (H₂S)-releasing NSAIDs, selenium (Se)–NSAIDs, and several other NSAID hybrid conjugates that have been shown to have favorable gastrointestinal tolerance. Research efforts are growing exponentially, and a variety of novel NSAID derivatives are emerging as a result. These NSAID-based compounds are designed following different approaches, all of them well-recognized in medicinal chemistry, resulting in new analogs with improved biological activity, pharmacological features, and safety profiles. Additionally, new applications and molecular mechanisms of action are being identified for the successful treatment of a plethora of diseases.

Thereby, the present Special Issue intends to gather information on the latest derivatives of NSAIDs along with unmodified NSAIDS’ new applications and molecular mechanisms of action in the context of any disease. Both research and review papers are welcome.

Potential topics include but are not limited to:

• Chemical design and synthesis of derivatives based on NSAIDs;
• Molecular mechanisms of action of NSAIDs and their derivatives;
• In vitro and in vivo biological activities in different diseases including cancer, inflammation-related conditions, CNS disorders, and infectious diseases;
• The combination of NSAIDs or their derivatives with other drugs/compounds;
• Biodistribution and pharmacological properties of NSAIDs and their derivatives.

Prof. Dr. Arun Sharma
Dr. Daniel Plano Amatriain
Guest Editors

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• NSAID derivatives
• chemical synthesis
• biological activity
• pharmacology
• mechanism of action
• cancer
• inflammation
• CNS disorders
• infectious diseases