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Molecules
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Green and Sustainable Solvents III
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Green and Sustainable Solvents III

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 2560

Special Issue Editor

Dr. Monica Nardi

E-Mail Website
Guest Editor
Dipartimento di Scienze della Salute, Università Magna Græcia, Viale Europa, Germaneto, 88100 Catanzaro, CZ, Italy
Interests: catalysis; green chemistry; organic synthesis; natural compounds; sustainable chemical processes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Green solvents are a topic of important interest among both the scientific research community and the chemical industry. In recent years, toxic solvents have had a huge impact on pollution, energy usage, and contributions to air quality and climate change. This Special Issue, “Green and Sustainable Solvents III”, aims to collect and publish recent advances in this interdisciplinary area. Research articles as well as reviews dealing with innovative techniques, alternative solvents, byproduct valorization, and new routes for green solvents toward industrial applications are of interest. Manuscripts on how green solvents contribute to the development of natural products research are welcome. Molecules is very pleased to host this Special Issue and invites scientists to submit their original contributions.

Prof. Dr. Monica Nardi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green chemistry
  • solvent free
  • catalysis
  • green solvents
  • environmental impact
  • natural compounds

Published Papers (1 paper)

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Research

11 pages, 1686 KiB  
Article
Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach
by Andrea Francesca Quivelli, Federico Vittorio Rossi, Chiara Alario, Francesco Sannicolò, Paola Vitale, Joaquín García-Álvarez, Filippo Maria Perna and Vito Capriati
Molecules 2022, 27(21), 7594; https://doi.org/10.3390/molecules27217594 - 05 Nov 2022
Cited by 4 | Viewed by 1889
Abstract
Dimethindene is a selective histamine H1 antagonist and is commercially available as a racemate. Upon analyzing the synthetic pathways currently available for the industrial preparation of dimethindene, we set up a sustainable approach for the synthesis of this drug, switching from petroleum-based [...] Read more.
Dimethindene is a selective histamine H1 antagonist and is commercially available as a racemate. Upon analyzing the synthetic pathways currently available for the industrial preparation of dimethindene, we set up a sustainable approach for the synthesis of this drug, switching from petroleum-based volatile organic compounds (VOCs) to eco-friendly solvents, such as 2-methyltetrahydrofuran (2-MeTHF) and cyclopentyl methyl ether (CPME) belonging to classes 3 and 2, respectively. Beyond decreasing the environmental impact of the synthesis (E-factor: 24.1–54.9 with VOCs; 12.2–22.1 with 2-MeTHF or CPME), this switch also improved the overall yield of the process (from 10% with VOCs to 21–22% with 2-MeTHF or CPME) and remarkably simplified the manual operations, working under milder conditions. Typical metrics applied at the first and second pass, according to the CHEM21 metrics toolkit, were also calculated for the whole synthetic procedure of dimethindene, and the results were compared with those of the classical procedure. Full article
(This article belongs to the Special Issue Green and Sustainable Solvents III)
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