Polyketides-II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 March 2019) | Viewed by 361
Special Issue Editor
Interests: molecular enzymology; structural biology and genetic engineering of polyketide synthases (PKS) and hybrid PKS-nonribosomal peptide synthetases (NRPS)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The study of polyketide synthase (PKSs) enzymes has grown over the last quarter-century into a dynamic area, encompassing a multiplicity of complementary approaches, from metagenomics to microbiology, in vitro enzymology to structural biology, and molecular genetics to synthetic biology. A striking picture that has emerged is of the extraordinary diversity of these systems and their capacity to intersect with other types of biosynthetic pathways, even as the roles played by the polyketide metabolites for their produces often remain obscure. This second Special Issue aims to encompass papers at the forefront of research in the field, by treating in particular the following topical issues: Novel types of PKS domain enzymology; new types of biosynthetic pathways in which PKSs are implicated; efforts to discover new polyketides by exploiting advances in genome mining (identification of novel producers, activation of silent pathways, heterologous expression, etc.); new insights into PKS function gleaned from structural biology and allied biophysical approaches; emerging information on the functions of these metabolites in the environment (chemical ecology); and novel synthetic biology approaches towards manipulating PKSs towards the generation of analogs for biological testing.
As Guest Editor, I cordially invite researchers to submit their work relevant to these questions to this Special Issue of Molecules.
Prof. Dr. Kira Weissman
Guest Editor
Manuscript Submission Information
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Keywords
- biosynthesis
- polyketide natural products
- polyketide synthases
- mechanistic enzymology
- genetic engineering
- structural biology
- genome mining
- chemical ecology
