New Approaches to Counteract Drug Resistance in Cancer

Dear Colleagues,

Drug resistance in cancer, either intrinsic or acquired, is a major impediment to the success of cancer treatment. This clinical problem has proven very difficult to resolve, due to several factors, such as intratumor heterogeneity and tumor dynamics, together with the presence of cancer stem cells in tumors and the intercellular transfer of drug resistance mediated by extracellular vesicles (such as exosomes or microvesicles). This Special Issue of Molecules intends to collect state-of-the-art original research and review articles on new approaches to counteract drug resistance in cancer, which may include but are not exclusively limited to articles on: novel compounds or small molecules designed for drug targets responsible for drug resistance, compounds isolated from natural products with chemosensitizing effects, new RNAi therapeutics, based on antimiRs or siRNAs, designed towards targets responsible for drug resistance, or innovative drug delivery approaches to improve response to therapy. Articles on the development of new methods to detect resistance to antitumor drugs will also be considered.

Dr. Helena Vasconcelos
Guest Editor

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