Magnetic Nanoparticles: Tools for Drug Delivery, Therapy and Imaging

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1650

Special Issue Editor


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Guest Editor
Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
Interests: magnetic nanoparticles; drug delivery; theranostic; hyperthermia; cytotoxicity; in vitro evaluation; in vivo evaluation

Special Issue Information

Dear Colleagues,

Magnetic nanoparticle applications in the domain of personalized medicine through diagnosis and therapy have attracted tremendous interest in the scientific community. These nanoparticles are highly stable and have been successfully studied for the delivery of hydrophobic and hydrophilic entities in combination with real-time monitoring and targeted release under the application of a magnetic field. This behavior is the start of a big roadmap about the mechanisms of magnetic nanoparticle cell interactions. Different parameters will be taken into consideration like shape, size composition and surface chemistry.

In this Special Issue, we kindly invite authors to report experimental and theoretical results about novel magnetic nanoparticles and their mechanisms on drug release, mechanism diagnosis and therapy.

Dr. Eleni Efthimiadou
Guest Editor

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Keywords

  • magnetic nanoparticles
  • magnetic hyperthermia
  • internalization mechanisms
  • in vitro evaluation
  • drug delivery
  • diagnostic techniques
  • therapeutic approaches
  • in vivo studies

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Published Papers (1 paper)

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Research

13 pages, 2931 KiB  
Article
Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
by Danai E. Prokopiou, Anastasia Chillà, Francesca Margheri, Gabriella Fibbi, Anna Laurenzana and Eleni K. Efthimiadou
Pharmaceutics 2024, 16(4), 527; https://doi.org/10.3390/pharmaceutics16040527 - 11 Apr 2024
Viewed by 1254
Abstract
This study investigates the distinctive characteristics of iron oxide magnetic nanoparticles (mNPs) and their potential application in cancer therapy, focusing on melanoma. Three types of mNPs, pre-validated for safety, underwent molecular analysis to uncover the activated signaling pathways in melanoma cells. Using the [...] Read more.
This study investigates the distinctive characteristics of iron oxide magnetic nanoparticles (mNPs) and their potential application in cancer therapy, focusing on melanoma. Three types of mNPs, pre-validated for safety, underwent molecular analysis to uncover the activated signaling pathways in melanoma cells. Using the Western blot technique, the study revealed that mNPs induce cytotoxicity, hinder proliferation through ERK1/2 dephosphorylation, and prompt proapoptotic effects, including DNA damage by inducing H2AX phosphorylation. Additionally, in vitro magnetic hyperthermia notably enhanced cellular damage in melanoma cells. Moreover, the quantification of intracellular iron levels through Inductively Coupled Plasma Mass Spectrometry (ICP-MS) analysis unveils the precise dosage required to induce cellular damage effectively. These compelling findings not only shed light on the therapeutic potential of mNPs in melanoma treatment but also open exciting avenues for future research, heralding a new era in the development of targeted and effective cancer therapies. Indeed, by discerning the effective dose, our approach becomes instrumental in optimizing the therapeutic utilization of iron oxide magnetic nanoparticles, enabling the induction of precisely targeted and controlled cellular responses. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles: Tools for Drug Delivery, Therapy and Imaging)
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