Lymphatic Aspects of Drug Delivery, Formulation, and Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 64
Special Issue Editors
Interests: pharmacokinetics; chirality; drug interactions; formulation and drug delivery
Special Issues, Collections and Topics in MDPI journals
Interests: chemistry; drug delivery; chromatography; zeta potential; pharmacology
Interests: biopharmaceutics; inhalable nanopartilces; traditional medicines
Special Issue Information
Dear Colleagues,
The lymphatic system plays a pivotal role in immune response and fluid balance and offers a promising alternative pathway for targeted drug delivery and disposition. Pharmaceutical advancements in lymphatic delivery and disposition encompass a spectrum of techniques and formulations aimed at optimizing bioavailability, stability, and therapeutic efficacy of drugs.
This Special Issue will delve into diverse facets of lymphatic delivery and disposition, spanning traditional, contemporary, and cutting-edge methodologies. From exploring novel carriers for enhanced bioavailability to unravelling the intricacies of dissolution, lipolysis, release kinetics, and stability concerns, this Special Issue will elucidate strategies to harness the lymphatic system for improved therapeutic outcomes.
Key topics to be addressed include the following:
- Targeted Delivery Systems: investigating innovative delivery systems tailored to exploit the lymphatic route for precise drug targeting and modified release;
- Bioavailability Enhancement: formulation techniques and strategies to enhance the bioavailability of drugs through lymphatic absorption, overcoming barriers such as poor solubility and permeability;
- Release Kinetics and Stability: analyzing the kinetics of drug release within the lymphatic system and addressing stability challenges to ensure optimal therapeutic efficacy;
- Toxicity and Safety: assessing the impact of lymphatic delivery on drug toxicity and safety profiles, with a focus on mitigating adverse effects and improving patient outcomes;
- Innovative Technologies and Clinical Applications: exploring emerging technologies and methodologies, including nanomedicine and lipid-based formulations, lymphatic dissolution techniques, PBPK models, and targeted lymphatic drug delivery and disposition.
By fostering interdisciplinary pharmaceutical discourse and sharing cutting-edge research, this Special Issue aims to advance our understanding of lymphatic delivery and disposition, paving the way for the development of novel therapeutic interventions with enhanced efficacy and safety profiles.
We invite contributions spanning original research articles, reviews, and perspectives that shed light on the pharmaceutical aspects of lymphatic delivery and disposition, driving innovation and transformation in drug development and delivery.
We look forward to your valuable insights and contributions.
Prof. Dr. Neal M. Davies
Prof. Dr. Nadia Araci Bou-Chacra
Prof. Dr. Raimar Löbenberg
Guest Editors
Manuscript Submission Information
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Keywords
- targeted delivery systems
- bioavailability enhancement
- release kinetics
- dissolution, solubility, and stability
- toxicity and safety
- lipid-based formulations and lipolysis
