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Pharmaceutics
Special Issues
Curcumin in Biomedical Applications, 2nd Edition
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Curcumin in Biomedical Applications, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 7085

Special Issue Editors

Prof. Dr. Taesun Min

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Guest Editor
Department of Animal Biotechnology, Jeju International Animal Research Center (JIA) and Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju 63243, Republic of Korea
Interests: bioavailability of poorly soluble drugs; nanotechnology; nanomedicine; biotechnology; pharmacology; veterinary medicine; animal science
Special Issues, Collections and Topics in MDPI journals
Dr. Adhimoolam Karthikeyan

E-Mail Website
Guest Editor
Subtropical Horticulture Research Institute, Jeju National University, Jeju 63243, Republic of Korea
Interests: nanomedicine; phytomedicine; genomics; proteomics; pharmacokinetics; characterization of nanoparticles; bioactive functional compounds; cell line culture; animal models
Dr. Mohammad Moniruzzaman

E-Mail Website
Guest Editor
Department of Animal Biotechnology, Jeju International Animal Research Center (JIA) and Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju 63243, Republic of Korea
Interests: nanomedicine; nanocarriers; pharmacology; toxicology; biotechnology; nanotechnology; animal nutrition; animal physiology; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Curcumin, a hydrophobic and polyphenolic compound extracted from the perennial herb Curcuma longa, is used in various biomedical applications. Curcumin has antioxidant, antimicrobial, anti-inflammatory, and neuroprotective effects on human and animal health; it has several limitations, including poor water solubility and an unstable chemical structure, rapid metabolization but poor absorption in the body, as well as differing utilization and bioavailability depending on the species and sex of the organism. In this regard, curcumin in the form of a nanoparticle has been widely reported to enhance the bioavailability and solubility of lipophilic curcumin. In recent years, several studies have shown the beneficial effects of nanocurcumin over native curcumin in terms of quantity and efficacy. It is also important to know how effectively nanocurcumin can work in biological systems based on pharmacokinetic and pharmacodynamic tools. For this, different types of carrier vehicles, such as lipid nanoparticles and polymeric nanoparticles, can be used to increase the bioavailability of curcumin. The utilization of novel formulations of curcumin in medical and veterinary applications may improve the health status of humans as well as the sustainable production of farm animals. In addition, its use might help minimize the excessive use of antibiotics in biomedical applications.

This Special Issue intends to focus on research articles and review papers covering recent progress and achievements in curcumin research in both human and animal science.

Prof. Dr. Taesun Min
Dr. Adhimoolam Karthikeyan
Dr. Mohammad Moniruzzaman
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • curcumin
  • biotechnology
  • pharmacology
  • nanospheres
  • nanocarriers
  • drug delivery
  • human
  • aquatic animal
  • terrestrial animal
  • in vitro study
  • in vivo study

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Published Papers (4 papers)

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Research

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20 pages, 9133 KiB  
Article
Utilizing an Ex Vivo Skin Penetration Analysis Model for Predicting Ocular Drug Penetration: A Feasibility Study with Curcumin Formulations
by Christian Raab, Stefan Brugger, Jara-Sophie Lechner, Geisa Nascimento Barbalho, Taís Gratieri, Priyanka Agarwal, Ilva D. Rupenthal and Cornelia M. Keck
Pharmaceutics 2024, 16(10), 1302; https://doi.org/10.3390/pharmaceutics16101302 - 6 Oct 2024
Viewed by 744
Abstract
Objective: This study aimed to investigate the feasibility of using the digital image processing technique, developed to semi-quantitatively study dermal penetration, to study corneal penetration in an ex vivo porcine eye model. Here, we investigated various formulation strategies intended to enhance dermal and [...] Read more.
Objective: This study aimed to investigate the feasibility of using the digital image processing technique, developed to semi-quantitatively study dermal penetration, to study corneal penetration in an ex vivo porcine eye model. Here, we investigated various formulation strategies intended to enhance dermal and corneal bioavailability of the model hydrophobic drug, curcumin. Methods: Several formulation principles were explored, including oily solutions, oily suspensions, aqueous nanosuspension, micelles, liposomes and cyclodextrins. The dermal penetration efficacy was tested using an ex vivo porcine ear model previously developed at Philipps-Universität Marburg with subsequent digital image processing. This image analysis method was further applied to study corneal penetration using an ex vivo porcine whole-eye model. Results: For dermal penetration, oily solutions, oily suspensions and nanosuspensions exhibited the least penetration, whereas liposomes and cyclodextrins showed enhanced penetration. Corneal curcumin penetration correlated with dermal penetration, with curcumin loaded into cyclodextrins penetrating the deepest. Conclusions: Overall, our study suggests that the image analysis method previously developed for ex vivo skin penetration can easily be repurposed to study corneal penetration of hydrophobic drugs. Full article
(This article belongs to the Special Issue Curcumin in Biomedical Applications, 2nd Edition)
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12 pages, 2521 KiB  
Article
Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice
by Felipe S. Arruda, Fernanda D. Tomé, Anália C. Milhomem, Pablo I. R. Franco, Allisson B. Justino, Rodrigo R. Franco, Erica C. Campos, Foued S. Espindola, Danilo F. Soave and Mara Rubia N. Celes
Pharmaceutics 2024, 16(8), 1105; https://doi.org/10.3390/pharmaceutics16081105 - 22 Aug 2024
Viewed by 892
Abstract
Doxorubicin (DOX) is a potent chemotherapeutic agent used to treat multiple types of cancer, but its clinical application is limited by cardiotoxicity, mainly due to oxidative stress. Curcumin (CUR) is a natural polyphenolic compound with strong antioxidant properties, but its potential protective effects [...] Read more.
Doxorubicin (DOX) is a potent chemotherapeutic agent used to treat multiple types of cancer, but its clinical application is limited by cardiotoxicity, mainly due to oxidative stress. Curcumin (CUR) is a natural polyphenolic compound with strong antioxidant properties, but its potential protective effects against DOX-induced cardiotoxicity need further investigation. This study aimed to evaluate CUR’s efficacy in mitigating DOX-induced oxidative stress in the hearts of BALB/c mice. Mice received a DOX dose of 9 mg/kg or 16 mg/kg; half of the mice received daily doses of 100 mg/kg CUR for 15 days. Survival analysis, histopathological examination, and oxidative stress markers were assessed to determine the cardioprotective effects of CUR. Results showed that CUR significantly reduced oxidative damage and improved survival rates, particularly at the lower DOX dose (9 mg/kg). Mice treated with DOX-9 mg/kg plus CUR showed improved health conditions and reduced levels of reactive oxygen species (ROS), lipid peroxidation, sulfhydryl production, and protein carbonylation. Histopathological analysis confirmed reduced cardiac tissue damage. In conclusion, CUR combined with a lower dose of DOX effectively reduces oxidative stress and cardiac injury, enhancing survival in BALB/c mice. These findings suggest that CUR is a promising adjunct therapy to mitigate DOX-induced cardiotoxicity, potentially improving the DOX therapeutic index in cancer treatment. Full article
(This article belongs to the Special Issue Curcumin in Biomedical Applications, 2nd Edition)
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15 pages, 2298 KiB  
Article
Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes
by Amina Ben Mihoub, Kamil Elkhoury, Janske Nel, Samir Acherar, Emilie Velot, Catherine Malaplate, Michel Linder, Shahrzad Latifi, Cyril Kahn, Marion Huguet, Frances T. Yen and Elmira Arab-Tehrany
Pharmaceutics 2023, 15(12), 2665; https://doi.org/10.3390/pharmaceutics15122665 - 24 Nov 2023
Cited by 3 | Viewed by 1523
Abstract
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but its use in biological applications is hindered by its sensitivity to light, oxygen, and temperature. Furthermore, due to its low water solubility, curcumin has a poor pharmacokinetic profile and bioavailability. In this [...] Read more.
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but its use in biological applications is hindered by its sensitivity to light, oxygen, and temperature. Furthermore, due to its low water solubility, curcumin has a poor pharmacokinetic profile and bioavailability. In this study, we evaluated the potential application of curcumin as a neuroprotective agent encapsulated in RGD peptide-PEGylated nanoliposomes developed from salmon-derived lecithin. Salmon lecithin, rich in polyunsaturated fatty acids, was used to formulate empty or curcumin-loaded nanoliposomes. Transmission electron microscopy, dynamic light scattering, and nanoparticle tracking analysis characterizations indicated that the marine-derived peptide-PEGylated nanoliposomes were spherical in shape, nanometric in size, and with an overall negative charge. Cytotoxicity tests of curcumin-loaded nanoliposomes revealed an improved tolerance of neurons to curcumin as compared to free curcumin. Wild-type SH-SY5Y were treated for 24 h with curcumin-loaded nanoliposomes, followed by 24 h incubation with conditioned media of SH-SY5Y expressing the Swedish mutation of APP containing a high ratio of Aβ40/42 peptides. Our results revealed significantly lower Aβ-induced cell toxicity in cells pre-treated with RGD peptide-PEGylated curcumin-loaded nanoliposomes, as compared to controls. Thus, our data highlight the potential use of salmon lecithin-derived RGD peptide PEGylated nanoliposomes for the efficient drug delivery of curcumin as a neuroprotective agent. Full article
(This article belongs to the Special Issue Curcumin in Biomedical Applications, 2nd Edition)
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Review

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22 pages, 1808 KiB  
Review
Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations
by Jibira Yakubu and Amit V. Pandey
Pharmaceutics 2024, 16(5), 637; https://doi.org/10.3390/pharmaceutics16050637 - 9 May 2024
Cited by 2 | Viewed by 3297
Abstract
Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance [...] Read more.
Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes. Full article
(This article belongs to the Special Issue Curcumin in Biomedical Applications, 2nd Edition)
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