Liposomes Applied in Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 907

Special Issue Editors


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Guest Editor
1. Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
2. Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
Interests: the development of new drug delivery systems by means of colloidal carriers; the structural characterization of proteins entrapped into micro- and nanocarriers; the lyophilization of biopharmaceuticals; the targeted and controlled delivery of drugs across biological barriers; the solid-state characterization of pharmaceuticals and the drying of pharmaceuticals and biopharmaceuticals; regenerative medicine
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iBB–Institute for Bioengineering and Biosciences, Department of Bioengineering, and Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais 1, 1049-001 Lisbon, Portugal
Interests: chemical synthesys; polymer synthesis; nanomaterials; nanoparticles; drug delivery; selective targeting

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Institute for Bioengineering and Biosciences, Department of Bioengineering, and Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, University of Lisboa, 1049-001 Lisbon, Portugal
Interests: nanotechnology; drug delivery systems; regenerative medicine; synthetic biology; genome editing; lactic acid bacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite and welcome submissions to this Special Issue the Pharmaceutics journal. This issue focuses on the advancements and applications of liposomes in drug delivery, highlighting their role in targeted therapy and diagnosis. Since its first appearance, a lot of research has aimed at bridging the gap between the lab and the market. Therefore, the focus is on various aspects of liposomes in drug delivery, including but not limited to the design and synthesis of liposomes, advancements in targeted drug delivery using liposomes, the role of liposomes in gene therapy, innovations in liposome formulations for enhanced drug stability and the application of liposomes in specific medical conditions such as cancer therapy, regenerative medicine and others. This issue is a vital contribution to the field of nanomedicine, showcasing the versatility and efficiency of liposomes as drug carriers.

Dr. Pedro Fonte
Dr. Teresa Esteves
Dr. Sofia de Oliveira Dias Duarte
Guest Editors

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Keywords

  • liposome
  • targeted drug delivery
  • nanomedicine
  • gene therapy
  • liposomal formulations
  • drug delivery
  • vaccine
  • biomaterial

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Published Papers (1 paper)

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Review

34 pages, 3009 KiB  
Review
Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective
by Mubashar Rehman, Nayab Tahir, Muhammad Farhan Sohail, Muhammad Usman Qadri, Sofia O. D. Duarte, Pedro Brandão, Teresa Esteves, Ibrahim Javed and Pedro Fonte
Pharmaceutics 2024, 16(11), 1376; https://doi.org/10.3390/pharmaceutics16111376 - 26 Oct 2024
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Abstract
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems [...] Read more.
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled release. In the 1990s, solid-phase lipids were introduced to reduce drug leakage from nanoparticles and prolong drug release. Manipulating the structure of emulsions and solid lipid nanoparticles has enabled multifunctional nanoparticles and the loading of therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids and surfactants with a well-defined polar head and carbon chain have been used to prepare bilayer vesicles known as liposomes and niosomes, respectively. The increasing knowledge of targeting ligands and external factors to gain control over pharmacokinetics and the ever-increasing number of synthetic lipids are expected to make lipid nanoparticles and vesicular systems a preferred choice for the encapsulation and targeted delivery of therapeutic agents. This review discusses different lipids and oil-based nanoparticulate systems for the delivery of water-insoluble drugs. The salient features of each system are highlighted, and special emphasis is given to studies that compare them. Full article
(This article belongs to the Special Issue Liposomes Applied in Drug Delivery Systems)
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