Enhancing Cancer Therapeutics: Harnessing Nanoplatforms for Mitochondria-Targeted Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 10 January 2025 | Viewed by 1811

Special Issue Editors

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multidisciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Interests: nanomedicines; biomaterials; drug delivery
Special Issues, Collections and Topics in MDPI journals
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Interests: nanomaterials; mitochondria; cancer; diabetes; drug delivery

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Guest Editor
Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China
Interests: nanomedicine; biomaterials; cancer immunotherapy

Special Issue Information

Dear Colleagues,

Mitochondria, the powerhouse of the cell, play a crucial role in cellular energy production and regulation of apoptosis. Targeting mitochondria has emerged as a promising strategy in cancer therapy due to the altered metabolism and mitochondrial dysfunction observed in cancer cells. Nanomedicine offers exciting opportunities in delivering therapeutic agents specifically to mitochondria, thereby enhancing efficacy and reducing off-target effects. This rapidly evolving field of nanomedicine holds great potential for revolutionizing cancer treatment by providing targeted therapies with improved selectivity and precision.

This Special Issue welcomes manuscripts focusing on the following themes:

  1. Design and synthesis of mitochondria-targeting nanocarriers for cancer therapy;
  2. Mitochondrial-specific drug delivery systems for overcoming multidrug resistance in cancer;
  3. Therapeutic strategies utilizing nanomedicine to modulate mitochondrial dynamics and functions in cancer cells;
  4. Mitochondrial imaging techniques using nanoprobes for cancer diagnosis and treatment monitoring;
  5. Mitochondria-targeted nanomedicine for combination therapies in cancer treatment;
  6. Nanotechnology-based approaches for enhancing mitochondrial photodynamic therapy in cancer;
  7. Safety, toxicity, and biocompatibility considerations in the development of mitochondria-targeted nanomedicine.

I look forward to receiving your contributions.

Dr. Jun Chen
Dr. Lifo Ruan
Dr. Mengxue Zhou
Guest Editors

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Keywords

  • nanomedicine
  • mitochondria-targeting
  • cancer therapy
  • mitochondrial dynamics
  • cancer diagnosis
  • mitochondrial photodynamic therapy

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Published Papers (1 paper)

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Review

20 pages, 7459 KiB  
Review
Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment
by Mingchuan Yang, Yufeng He, Qingqing Ni, Mengxue Zhou, Hongping Chen, Guangyun Li, Jizhong Yu, Ximing Wu and Xiangchun Zhang
Pharmaceutics 2024, 16(8), 972; https://doi.org/10.3390/pharmaceutics16080972 - 23 Jul 2024
Viewed by 977
Abstract
Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting mitochondrial function, yet their structural instability and low bioavailability hinder their utility. [...] Read more.
Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting mitochondrial function, yet their structural instability and low bioavailability hinder their utility. To overcome this challenge, researchers have utilized the inherent physical and chemical characteristics of polyphenols and their derivatives to develop innovative nanomedicines for targeting mitochondria. This review examines the construction strategies and anticancer properties of various types of polyphenol-based biological nanomedicine for regulating mitochondria in recent years, such as polyphenol self-assembly, metal–phenol network, polyphenol–protein, polyphenol–hydrogel, polyphenol–chitosan, and polyphenol–liposome. These polyphenolic nanomedicines incorporate enhanced features such as improved solubility, efficient photothermal conversion capability, regulation of mitochondrial homeostasis, and ion adsorption through diverse construction strategies. The focus is on how these polyphenol nanomedicines promote ROS production and their mechanism of targeting mitochondria to inhibit cancer. Furthermore, it delves into the benefits and applications of polyphenolic nanomedicine in cancer treatments, as well as the challenges for future research. Full article
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