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Pharmaceutics
Special Issues
Novel Technologies for Buccal and Transdermal Drug Delivery
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Novel Technologies for Buccal and Transdermal Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 9725

Special Issue Editors

Dr. Cristina Prieto

E-Mail Website
Guest Editor
Novel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, Spain
Interests: encapsulation; biopolymers; bioactive compounds; nanotechnology; supercritical fluids
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Pardo-Figuerez

E-Mail Website
Guest Editor
Novel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna, 46980 Valencia, Spain
Interests: drug delivery; biomaterials; electrohydrodynamic processing; solid dispersions; tissue engineering

Special Issue Information

Dear Colleagues,

The discovery of new drug candidates with poor water solubility as well as a strong first-pass effect present ongoing challenges regarding their translation into potential medical therapies. In light of this, researchers are focusing their efforts on finding alternative technologies and delivery systems to improve the solubilization and bioavailability of these drugs. In particular, interest has been focused on the use of electrohydrodinamic processing for the generation of drug delivery platforms to enhance drug permeability and solubility. This technique can be used to generate the solid dispersions of an API within a polymer matrix, generating solid pharmaceutical formulations that can adhere to the mucosa membrane. Moreover, the resultant fibrous materials have a high specific area, tunable pore size and controlled mechanical properties, making them attractive in drug delivery applications. This Special Issue is focused on highlighting the current trends and perspectives of buccal and transdermal delivery systems prepared by emerging technologies, such as electrohydrodinamic processing, among others.

We look forward to receiving your contributions.

Dr. Cristina Prieto
Dr. Maria Pardo-Figuerez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • solid dispersion
  • transdermal delivery
  • buccal delivery
  • electrohydrodynamic processing
  • biomaterials

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Published Papers (5 papers)

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Research

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16 pages, 3187 KiB  
Article
Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials
by Jorge Teno, Maria Pardo-Figuerez, Zoran Evtoski, Cristina Prieto, Luis Cabedo and Jose M. Lagaron
Pharmaceutics 2024, 16(2), 220; https://doi.org/10.3390/pharmaceutics16020220 - 3 Feb 2024
Cited by 2 | Viewed by 1723
Abstract
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can [...] Read more.
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can more efficiently act on the site of action during wound closure, avoiding post-operative bacterial infection and spreading. This work was aimed at developing novel electrospun bio-based anti-infective fibre-based yarns as novel suture materials for preventing surgical site infections. For this, yarns based on flying intertwined microfibres (1.95 ± 0.22 µm) were fabricated in situ during the electrospinning process using a specially designed yarn collector. The electrospun yarn sutures (diameter 300–500 µm) were made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different contents of 3HV units and contained ciprofloxacin hydrochloride (CPX) as the antimicrobial active pharmaceutical ingredient (API). The yarns were then analysed by scanning electron microscopy, Fourier transform infrared spectroscopy, wide-angle X-ray scattering, differential scanning calorimetry, and in vitro drug release. The yarns were also analysed in terms of antimicrobial and mechanical properties. The material characterization indicated that the varying polymer molecular architecture affected the attained polymer crystallinity, which was correlated with the different drug-eluting profiles. Moreover, the materials exhibited the inherent stiff behaviour of PHBV, which was further enhanced by the API. Lastly, all the yarn sutures presented antimicrobial properties for a time release of 5 days against both Gram-positive and Gram-negative pathogenic bacteria. The results highlight the potential of the developed antimicrobial electrospun yarns in this study as potential innovative suture materials to prevent surgical infections. Full article
(This article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery)
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10 pages, 1207 KiB  
Article
Transdermal Drug Delivery of Tazarotene: Determining Tazarotene’s Potential in Local Transdermal Therapy
by Helena Hamzehpour, Ástrós Óskarsdóttir, Helgi Jónsson, Fjóla Jónsdóttir, Ólafur E. Sigurjónsson and Bergthora S. Snorradottir
Pharmaceutics 2024, 16(1), 64; https://doi.org/10.3390/pharmaceutics16010064 - 31 Dec 2023
Cited by 1 | Viewed by 2025
Abstract
Retinoid-based drugs, while effective, are associated with systemic toxicity. Topical alternatives offer a safer option, and tazarotene, a third-generation synthetic retinoid, holds promise. This study investigates tazarotene’s transdermal delivery potential, focusing on its application for joint-related conditions. The aim of this study was [...] Read more.
Retinoid-based drugs, while effective, are associated with systemic toxicity. Topical alternatives offer a safer option, and tazarotene, a third-generation synthetic retinoid, holds promise. This study investigates tazarotene’s transdermal delivery potential, focusing on its application for joint-related conditions. The aim of this study was to investigate the suitability of tazarotene as a candidate for transdermal delivery into joints. In vitro permeation studies, using porcine skin, assessed tazarotene’s transdermal drug delivery from solution and gel formulations. A tape-stripping analysis determined stratum corneum retention and a pilot study using porcine joints assessed tazarotene’s ability to reach articular cartilage. Ultra Performance Liquid Chromatography coupled with a mass detector method was used to quantify tazarotene and tazarotenic acid permeation. The results validate that tazarotene can permeate porcine skin and accumulate in articular cartilage in detectable amounts. The detection of tazarotene and tazarotenic acid in both the in vitro permeation studies and the pilot study on porcine joints validate the drug’s potential therapeutic use for hand osteoarthritis. This study lays the groundwork for future research, contributing insights into tazarotene’s potential for transdermal drug delivery and guiding further exploration in topical retinoid applications. Full article
(This article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery)
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19 pages, 7459 KiB  
Article
Expanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue Regeneration
by Beatriz G. Bernardes, Sara Baptista-Silva, Carlos Illanes-Bordomás, Rui Magalhães, Juliana Rosa Dias, Nuno M. F. Alves, Raquel Costa, Carlos A. García-González and Ana Leite Oliveira
Pharmaceutics 2023, 15(11), 2605; https://doi.org/10.3390/pharmaceutics15112605 - 9 Nov 2023
Cited by 1 | Viewed by 1479
Abstract
A newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% (w/v)) were explored to investigate [...] Read more.
A newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% (w/v)) were explored to investigate the potential of this technology to produce size- and porosity-controlled particles. Laser diffraction, helium pycnometry, nitrogen adsorption–desorption analysis and Fourier Transform Infrared with Attenuated Total Reflectance (FTIR-ATR) spectroscopy were performed to characterize the physicochemical properties of the material. The enzymatic degradation profile of the SF aerogel particles was evaluated by immersion in protease XIV solution, and the biological properties by cell viability and cell proliferation assays. The obtained aerogel particles were mesoporous with high and concentration dependent specific surface area (203–326 m2/g). They displayed significant antioxidant activity and sustained degradation in the presence of protease XIV enzyme. The in vitro assessment using human dermal fibroblasts (HDF) confirm the particles’ biocompatibility, as well as the enhancement in cell viability and proliferation. Full article
(This article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery)
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18 pages, 2165 KiB  
Article
Biopolymer- and Natural Fiber-Based Biomimetic Tissues to Realize Smart Cosmeceuticals and Nutraceuticals Using an Innovative Approach
by Pierfrancesco Morganti, Maria-Beatrice Coltelli, Alessandro Gagliardini, Andrea Lazzeri, Gianluca Morganti, Giovanna Simonetti, Tilman Fritsch, Vittorio Calabrese, Alessandra Fusco and Giovanna Donnarumma
Pharmaceutics 2023, 15(11), 2525; https://doi.org/10.3390/pharmaceutics15112525 - 24 Oct 2023
Cited by 1 | Viewed by 1641
Abstract
More sustainable and smart cosmeceuticals and nutraceuticals are necessary due to the ecological transition. In this study, a pullulan-based water solution containing chitin nanofibril–nano-lignin (CN-LG) complexes that encapsulate fish collagen polypeptide, allantoin and nicotinamide was electrospun onto a nonwoven substrate made of bamboo [...] Read more.
More sustainable and smart cosmeceuticals and nutraceuticals are necessary due to the ecological transition. In this study, a pullulan-based water solution containing chitin nanofibril–nano-lignin (CN-LG) complexes that encapsulate fish collagen polypeptide, allantoin and nicotinamide was electrospun onto a nonwoven substrate made of bamboo fibers to obtain a smart nanostructured bilayer system for releasing active molecules onto the skin or other body tissues. Infrared spectroscopy was used to characterize the composition of the bilayer system before and after rapid washing of the sample with distilled water and liquids mimicking physiological fluids. The viability of keratinocytes was studied as well as the antioxidant activity, protective activity towards UV light, metalloproteinase release of aged fibroblasts and the inhibitor activity against collagen degradation. Immunomodulatory tests were performed to investigate the anti-inflammatory activity of the bilayer system as well as its indirect antimicrobial activity. The results indicate that the bilayer system can be used in the production of innovative sustainable cosmeceuticals. In general, the adopted strategy can be extended to several smart treatments for fast release that can be commercialized as solid products, thus avoiding the use of preservatives and water. Full article
(This article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery)
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Review

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19 pages, 1501 KiB  
Review
Research Progress of Extracellular Vesicles-Loaded Microneedle Technology
by Xue Wang, Wei Cheng and Jiandong Su
Pharmaceutics 2024, 16(3), 326; https://doi.org/10.3390/pharmaceutics16030326 - 26 Feb 2024
Cited by 1 | Viewed by 2066
Abstract
Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, [...] Read more.
Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, low immunogenicity, and cell-source-specific traits. MNs prove instrumental in extracting EVs from the sample fluid, thereby facilitating a promising diagnostic and prognostic tool. To harness the therapeutic potential of EVs in tissue repair, MNs with sustained delivery of EVs leverage micron-sized channels to enhance targeted site concentration, demonstrating efficacy in treating various diseases, such as Achillea tendinopathy, hair loss, spinal cord injury, and diabetic ulcers. EV-loaded MNs emerge as a promising platform for repair applications of skin, cardiac, tendon, hair, and spinal cord tissues. This review commences with an overview of MNs, subsequently delving into the role of EVs as cargo for MNs. The paper then synthesizes the latest advancements in the use of EV-loaded MNs for tissue regenerative repair, extending to research progress in extracting EVs from MNs for disease diagnosis and prognostic evaluations. It aims to offer valuable insights and forecast future research trajectories with the hope of inspiring innovative ideas among researchers in this field. Full article
(This article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery)
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