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6.9
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Pharmaceutics
Special Issues
Novel Transbuccal Drug Delivery Systems
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Novel Transbuccal Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 6178

Special Issue Editors

Dr. Giovana Calixto

E-Mail Website
Guest Editor
Department of Biosciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13083-970, Brazil
Interests: drug delivery systems; liquid crystalline system; polymers; rheology; texture profile analysis; mucoadhesion; oral mucosa; topical anesthetic
Prof. Dr. Michelle Franz-Montan

E-Mail Website
Guest Editor
Department of Biosciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13083-970, Brazil
Interests: topical anesthesia; oral cavity; oral mucosa; dental anesthesia; drug delivery; mucoadhesive system; dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The transbuccal administration of drug delivery systems is very advantageous, because this route is easily accessible, non-invasive, and avoids the first-pass gut and hepatic metabolism. In addition, due to the rich blood supply of oral mucosa, transbuccal delivery is an attractive route of administration that can also provide systemic effects. However, the complexity of the oral mucosa barrier makes it difficult to the total permeation of the drug. In addition, the continuous flow of saliva, chewing, and speech can also limit the transbuccal administration of drug delivery systems. Therefore, new strategies are required to increase drug retention and penetration using this route. We would like to invite you to contribute to this Special Issue with a short communication, full article or review with recent advances in the development, in vitro characterization, in vitro and in vivo biological assays, and clinical trials of novel transbuccal drug delivery systems.

Dr. Giovana Calixto
Prof. Dr. Michelle Franz-Montan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transbuccal administration
  • drug delivery systems
  • mucoadhesion
  • oral mucosa
  • oral cavity
  • in vitro characterization methods
  • biological assays

Published Papers (2 papers)

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17 pages, 1599 KiB  
Article
Bioadhesive Curcumin-Mediated Photodynamic Inactivation and Its Potential to Cause Undesirable Effects on Dental and Restorative Surfaces
by Bárbara Donadon Reina, Carolina Santezi Neto, Patrícia Petromilli Nordi Sasso Garcia, Marlus Chorilli, Giovana Maria Fioramonti Calixto and Lívia Nordi Dovigo
Pharmaceutics 2021, 13(9), 1458; https://doi.org/10.3390/pharmaceutics13091458 - 13 Sep 2021
Cited by 2 | Viewed by 1536
Abstract
Curcumin-mediated Photodynamic Inactivation (PDI) has shown great potential to disinfect specific sites on tooth enamel but may involve contact with restorative materials. Thus, before use in dentistry, it is necessary to investigate whether the PDI protocol causes undesirable changes in the surfaces of [...] Read more.
Curcumin-mediated Photodynamic Inactivation (PDI) has shown great potential to disinfect specific sites on tooth enamel but may involve contact with restorative materials. Thus, before use in dentistry, it is necessary to investigate whether the PDI protocol causes undesirable changes in the surfaces of aesthetic restorative materials and dental enamel. This study investigated the effect of PDI mediated by curcumin (CUR) in a liquid crystal precursor system on color stability (ΔE), surface roughness (Ra), and microhardness (kgf) of three different composite resins and bovine dental enamel specimens. The microhardness and roughness readings were performed 60 days after the treatments while the color readings were performed immediately, 24, 48, and 72 h, 7, 14, 21, 30, and 60 days after the treatments. Results showed that CUR mediated-PDI does not seem to have the potential to promote any esthetic or mechanical changes to the surface of tooth enamel and can be applied safely in clinical practice. However, the results on color, roughness, and hardness obtained for composite resins show that some negative effects can be produced, depending on the type of restorative material; more experiments must be performed with different formulations and, perhaps, with lower concentrations of CUR. Full article
(This article belongs to the Special Issue Novel Transbuccal Drug Delivery Systems)
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42 pages, 5605 KiB  
Systematic Review
Role of Photobiomodulation Therapy in Neurological Primary Burning Mouth Syndrome. A Systematic Review and Meta-Analysis of Human Randomised Controlled Clinical Trials
by Reem Hanna, Snehal Dalvi, Rene Jean Bensadoun, Judith E. Raber-Durlacher and Stefano Benedicenti
Pharmaceutics 2021, 13(11), 1838; https://doi.org/10.3390/pharmaceutics13111838 - 2 Nov 2021
Cited by 16 | Viewed by 3944
Abstract
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. The aim of this systematic review and meta-analysis of CRD [...] Read more.
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. The aim of this systematic review and meta-analysis of CRD 42020198921 PROSPERO registration reference was to oversee and determine the efficacy of PBMT in patients with npBMS, identifying the gaps and bridge them by proposing recommendations for future studies purposes. PRISMA guidelines and Cochrane Collaboration recommendations followed. Various search engines employed to analyse a total of 351 studies of which 12 were included. A wide range of utilised PBM wavelengths was between 635–980 nm and the power output ranged between 30 mW and 4000 mW. A high risk of bias (RoB) was noted in 7 out of 12 included studies (58.3%), as results of qualitative analysis. Meta-analysis findings of 4 out of 12 studies showed statistically significant intergroup differences (SSID) for visual analogue scale (VAS) values (MD = −1.47; 95% CI = −2.40 to −0.53; Z = 3.07 (p = 0.002) whereas meta-analysis on 5 out of 12 studies revealed SSID for anxiety/depression and quality of life (MD = −1.47; 95% CI = −2.40 to −0.53; Z = 3.07 (p = 0.002), favouring PBMT group to the control treatment strategies. Despite the inconsistency and diversity in PBM parameters (wavelength, power, light source, spot size, emission mode, energy per point, total energy) and treatment protocols (exposure time, number of sessions, time interval between sessions, treatment duration)—majority of the included studies showed positive PBM results. The high RoB and meta-analytical heterogeneity in the eligible studies warrant the necessity to perform well-designed and robust RCTs after acknowledging the drawbacks of the available scientific literature and addressing our suggested recommendations highlighted in our review. Full article
(This article belongs to the Special Issue Novel Transbuccal Drug Delivery Systems)
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