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Plants
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Purification and Identification of Natural Compounds with Antimicrobial Activity
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Purification and Identification of Natural Compounds with Antimicrobial Activity

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 8074

Special Issue Editor

Dr. Veronique Seidel

E-Mail Website
Guest Editor
Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
Interests: purification and structure elucidation of bioactive natural products; ethnopharmacological investigation of traditional natural remedies; bioassay-guided fractionation of natural extracts; screening of natural products for antimicrobial activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural sources are known to produce a range of highly diverse chemicals, many of which counteract microbes in the environment of the producing organism. Indeed, natural products played an important role in the discovery and development of the first antibiotics.

Plants have a long history of use in traditional medicine to prevent or cure infectious diseases. This Special Issue aims to focus on the current status of screening plant extracts and chemicals for their ability to provide new drug leads to tackle infections. Potential topics include, but are not limited to, plant-derived compounds with antibacterial, antifungal, antimycobacterial, antibiofilm, and antivirulence activity, as well as phytochemicals that target antimicrobial drug resistance.

Dr. Veronique Seidel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • antibiofilm activity
  • antivirulence activity
  • drug discovery
  • natural compounds

Published Papers (2 papers)

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Research

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17 pages, 1108 KiB  
Article
Endophytic Fungi Isolated from Ageratina adenophora Exhibits Potential Antimicrobial Activity against Multidrug-Resistant Staphylococcus aureus
by Juan Wen, Samuel Kumi Okyere, Jianchen Wang, Ruya Huang, Ya Wang, Lin Liu, Xiang Nong and Yanchun Hu
Plants 2023, 12(3), 650; https://doi.org/10.3390/plants12030650 - 1 Feb 2023
Cited by 4 | Viewed by 2488
Abstract
Multidrug-resistant bacteria such as Staphylococcus aureus (MRSA) cause infections that are difficult to treat globally, even with current available antibiotics. Therefore, there is an urgent need to search for novel antibiotics to tackle this problem. Endophytes are a potential source of novel bioactive [...] Read more.
Multidrug-resistant bacteria such as Staphylococcus aureus (MRSA) cause infections that are difficult to treat globally, even with current available antibiotics. Therefore, there is an urgent need to search for novel antibiotics to tackle this problem. Endophytes are a potential source of novel bioactive compounds; however, the harnessing of novel pharmacological compounds from endophytes is infinite. Therefore, this study was designed to identify endophytic fungi (from Ageratina adenophora) with antibacterial activity against multidrug-resistant bacteria. Using fungal morphology and ITS-rDNA, endophytic fungi with antibacterial activities were isolated from A. adenophora. The results of the ITS rDNA sequence analysis showed that a total of 124 morphotype strains were identified. In addition, Species richness (S, 52), Margalef index (D/, 7.3337), Shannon–Wiener index (H/,3.6745), and Simpson’s diversity index (D, 0.9304) showed that A. adenophora have abundant endophytic fungi resources. Furthermore, the results of the agar well diffusion showed that the Penicillium sclerotigenum, Diaporthe kochmanii, and Pestalotiopsis trachycarpicola endophytic fungi’s ethyl acetate extracts showed moderate antibacterial and bactericidal activities, against methicillin-resistant Staphylococcus aureus (MRSA) SMU3194, with a MIC of 0.5–1 mg/mL and a MBC of 1–2 mg/mL. In summary, A. adenophora contains endophytic fungi resources that can be pharmacologically utilized, especially as antibacterial drugs. Full article
(This article belongs to the Special Issue Purification and Identification of Natural Compounds with Antimicrobial Activity)
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Review

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26 pages, 1743 KiB  
Review
Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections
by Adelina-Gabriela Niculescu and Alexandru Mihai Grumezescu
Plants 2021, 10(9), 1847; https://doi.org/10.3390/plants10091847 - 6 Sep 2021
Cited by 10 | Viewed by 4476
Abstract
Oral health is an essential element in maintaining general well-being. By preserving the complex equilibrium within the oral microbial community, commensal microorganisms can protect against extrinsic pathogenic threats. However, when an imbalance occurs, the organism is susceptible to a broad range of infections. [...] Read more.
Oral health is an essential element in maintaining general well-being. By preserving the complex equilibrium within the oral microbial community, commensal microorganisms can protect against extrinsic pathogenic threats. However, when an imbalance occurs, the organism is susceptible to a broad range of infections. Synthetic drugs can be administered to help the body fight against the fungal, bacterial, or viral burden. Nonetheless, they may produce undesirable consequences such as toxicity, adverse effects, and drug resistance. In this respect, research has focused on finding safer and more efficient alternatives. Particularly, increasing attention has been drawn towards developing novel formulations based on natural compounds. This paper reviews the plant-based, algae-based, and beehive products investigated for their antimicrobial properties, aiming to thoroughly present the state of the art on oral infection prevention in the ear, nose, and throat (ENT) field. Full article
(This article belongs to the Special Issue Purification and Identification of Natural Compounds with Antimicrobial Activity)
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