Impact of Liquid Chromatography in Pharmaceutical Research and Beyond

Dear Colleagues,

Just as the early development of gas chromatography (GC) in the 1950s owed much to the post-World War 2 boom in the automotive industry and the consequent need for the analysis of volatile petroleum-based fuels, the subsequent development of high-performance liquid chromatography (HPLC) had strong links with the need for analysing non-volatile compounds during the rapid growth of the pharmaceutical industry that followed in later decades. By the early 1970s, HPLC was established in analytical groups in pharmaceutical R&D labs in developed nations worldwide. Soon, HPLC, or simply (modern) LC to give it its now more common parlance, became the “workhorse” of the pharmaceutical analysis laboratory, and it has remained ever so. Thus, fifty years on, the aim of this Special Issue is to celebrate the invaluable contribution that LC still makes to pharmaceutical R&D and beyond by publishing high-quality papers that best illustrate its contribution in recent times.

The scope of this Special Issues covers any application of LC in pre-discovery, discovery, pre-clinical development and clinical development. “Beyond” encompasses pharmaceutical manufacturing and the control of marketed drugs. In addition, the scope includes any new development in LC technology or practice that has the potential for the useful enhancement of drug analysis.

With respect to aspects of LC that might be featured, there is a myriad of possibilities. uHPLC, 2D-LC, modes of LC, chiral LC, preparative LC, LC detectors, computer-aided LC method development, LC determination of api and related substances, LC method validation, LC of biologicals, LC of new modalities, LC in -omics studies, LC drug bioanalysis, sustainable LC, LC column characterisation, LC-MS and other hyphenated forms of LC are just a few examples.

Accordingly, there are many opportunities for contributions from within the scope described. Therefore, submitted papers are strongly encouraged in order to make this Special Issue a truly worthy celebration of 50 years of pharmaceutical LC.

Dr. W John Lough
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• LC biochemical analysis
• LC-MS
• LC drug bioanalysis
• LC chiral separations
• api analysis by LC
• LC drug product analysis
• LC of biologicals