Skin Sensitization Testing Using New Approach Methodologies

Dear Colleagues,

At present,  the skin sensitization testing of chemical substances and products on the market can be conducted without animal testing. Integrating the results of individual test methods using defined approaches makes it possible to derive regulatory classifications for skin sensitization hazard or potency. Defined approaches that can be used for risk assessments to determine safe levels of sensitizers that are expected to be approved for regulatory use in the near future. This special edition seeks contributions that explore the application of new approach methodologies to overcome the regulatory challenges of assessing skin sensitization. These new approach methodologies include in chemico, in vitro, in silico, and other non-animal approaches and strategies that combine the outcomes of such methods. Interesting topics include, but are not limited to, the testing of mixtures (chemical products or medical device extracts, for example) for skin sensitization hazard or potency classification, test method development, and the evaluation of new methods, such as those to predict T cell proliferation, the development and use of appropriate reference data for evaluations, and the development of new defined approaches.

Dr. Judy Strickland
Guest Editor

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