Nanovaccines for Animal Infectious Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1103

Special Issue Editors


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Guest Editor
College of Veterinary Medicine, South China Agricultural University, National Joint Local Bioengineering Laboratory for Zoonosis, Key Laboratory of Animal Vaccine Development of the Ministry of Agriculture and Rural Affairs, No. 483, Wushan Street, Tianhe District, Guangzhou 510642, China
Interests: novel animal vaccine development; pathogenesis and immunological mechanisms of the rabies virus; development of oral vaccine vectors for infectious diseases of animals

E-Mail Website
Guest Editor
College of Veterinary Medicine, South China Agricultural University, National Joint Local Bioengineering Laboratory for Zoonosis, Key Laboratory of Animal Vaccine Development of the Ministry of Agriculture and Rural Affairs, No. 483, Wushan Street, Tianhe District, Guangzhou 510642, China
Interests: epidemiological characteristics and variation regularity of pathogen; regulate and control network of interaction between pathogen and host; new vaccine development

E-Mail Website
Guest Editor
Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China
Interests: prevention and control of virus diseases in aquatic animals

Special Issue Information

Dear Colleagues,

Vaccines play a pivotal role in safeguarding against animal infectious diseases, which not only impact global livestock production but also pose a risk to human health and security. The financial consequences of such diseases, ranging from production losses to trade restrictions, are immense. Vaccines, therefore, serve as a critical front-line defense, preventing, managing, and sometimes eradicating diseases. Traditional vaccines, though effective in certain cases, face challenges in terms of safety, efficacy, and speed of deployment. Nanovaccines offer enhanced efficacy and stability compared to traditional vaccines, owing to their precise targeting and controlled release mechanisms. These vaccines hold promise for the future, revolutionizing animal infectious disease prevention and control through improved immune response induction, broader pathogen coverage, and simplified administration protocols. We invite researchers working in diverse areas of nanovaccine research to contribute their insights and expertise to this exciting field, contributing to the global effort against animal infectious diseases.

This Special Issue cordially invites submissions of original research and review articles primarily focused on the preclinical and clinical development of vaccines in the field of prevention and control of animal infectious diseases, including LNP-mRNA vaccines, VLP vaccines, polymeric/inorganic nanoparticle vaccines, self-assembled protein vaccines, biomimetic nanoparticle vaccines, and so on.

Dr. Yongwen Luo
Prof. Dr. Huiying Fan
Dr. Qing Wang
Guest Editors

Manuscript Submission Information

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Keywords

  • LNP-mRNA vaccines
  • VLP vaccines
  • polymeric/inorganic nanoparticle vaccines
  • self-assembled protein vaccines
  • biomimetic nanoparticle vaccines

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Published Papers (1 paper)

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Research

16 pages, 3418 KiB  
Article
Development of a Ferritin-Based Nanoparticle Vaccine against Classical Swine Fever
by Yiwan Song, Zhongmao Yuan, Junzhi Ji, Yang Ruan, Xiaowen Li, Lianxiang Wang, Weijun Zeng, Keke Wu, Wenshuo Hu, Lin Yi, Hongxing Ding, Mingqiu Zhao, Shuangqi Fan, Zhaoyao Li and Jinding Chen
Vaccines 2024, 12(8), 948; https://doi.org/10.3390/vaccines12080948 - 22 Aug 2024
Viewed by 828
Abstract
The occurrence of classical swine fever (CSF) poses a significant threat to the global swine industry. Developing an effective and safe vaccine is crucial for preventing and controlling CSF. Here, we constructed self-assembled ferritin nanoparticles fused with the classical swine fever virus (CSFV) [...] Read more.
The occurrence of classical swine fever (CSF) poses a significant threat to the global swine industry. Developing an effective and safe vaccine is crucial for preventing and controlling CSF. Here, we constructed self-assembled ferritin nanoparticles fused with the classical swine fever virus (CSFV) E2 protein and a derived B cell epitope (Fe-E2B) using a baculovirus expression system (BVES), demonstrating enhanced immunogenicity. Furthermore, we provide a detailed evaluation of the immunological efficacy of the FeE2B in rabbits. The results showed that robust and sustained antibody responses were detected in rabbits immunized with the Fe-E2B nanoparticle vaccine, comparable to those elicited by commercially available vaccines. Additionally, we demonstrated that the vaccine effectively activated crucial immune factors IFN-γ and IL-4 in vivo, increasing their levels by 1.41-fold and 1.39-fold, respectively. Immunization with Fe-E2B enabled rabbits to avoid viremia and stereotypic fever after CSFV challenge. In conclusion, this study highlights the potential of ferritin nanoparticles as antigen-presenting carriers to induce robust immune responses, proposing a candidate vaccine strategy for the prevention and control of CSF. Full article
(This article belongs to the Special Issue Nanovaccines for Animal Infectious Diseases)
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