Oxidative Stress and Pathophysiology of Stroke

Dear Colleagues,

In this Special Issue, we aim to provide both a broad overview of the role oxidative stress plays in causing brain injury following a stroke and of the varying approaches taken to treat strokes by reducing oxidative stress. Stroke is a devastating disease that represents one of the leading causes of death in the United States and worldwide. Treatment options using mechanical thrombectomy and improved brain imaging have enabled new ways of thinking about the sequence of events that is unleashed by the original ischemic event, which is typically when a blood clot blocks one of the major arteries of the brain. These treatments can now be used to target stroke injury mechanisms in ways that were not available just a few years ago. In parallel, it is now even more obvious how oxidative stress contributes to hemorrhagic forms of stroke, including both intracerebral and subarachnoid hemorrhage. It is necessary to gain an enhanced understanding of oxidative-stress-related mechanisms in all stroke subtypes to develop effective mechanism-based treatments that work.

We would like to receive a wide range of manuscripts highlighting both mechanistic studies to further elucidate the role of oxidative stress, as well as translational approaches that can lead to novel treatments. We anticipate a mixture of original studies and focused review articles that will provide a comprehensive snapshot of our current understanding of the role oxidative stress plays in the pathophysiology of stroke.

Dr. Klaus Van Leyen
Guest Editor

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