Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation

Sun, Chen; Yao, Mengchao; Xiong, Ruiqi; Su, Yang; Zhu, Binglin; Chen, Yong-Cong; Ao, Ping

doi:10.3390/e26080631

Open AccessArticle

Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation

by

Chen Sun

^1,†

,

Mengchao Yao

^1,†,

Ruiqi Xiong

¹,

Yang Su

¹,

Binglin Zhu

¹,

Yong-Cong Chen

^1,* and

Ping Ao

^2,*

¹

Center for Quantitative Life Sciences & Physics Department, Shanghai University, Shanghai 200444, China

²

School of Biomedical Engineering, Sichuan University, Chengdu 610065, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Entropy 2024, 26(8), 631; https://doi.org/10.3390/e26080631

Submission received: 16 May 2024 / Revised: 21 July 2024 / Accepted: 22 July 2024 / Published: 26 July 2024

(This article belongs to the Special Issue From Functional Imaging to Free Energy—Dedicated to Professor Karl Friston on the Occasion of His 65th Birthday)

Download

Browse Figures

Review Reports Versions Notes

Abstract

How did the complex structure of the telencephalon evolve? Existing explanations are based on phenomena and lack a first-principles account. The Darwinian dynamics and endogenous network theory—established decades ago—provides a mathematical and theoretical framework and a general constitutive structure for theory–experiment coupling for answering this question from a first-principles perspective. By revisiting a gene network that explains the anterior–posterior patterning of the vertebrate telencephalon, we found that upon increasing the cooperative effect within this network, fixed points gradually evolve, accompanied by the occurrence of two bifurcations. The dynamic behavior of this network is informed by the knowledge obtained from experiments on telencephalic evolution. Our work provides a quantitative explanation for how telencephalon anterior–posterior patterning evolved from the pre-vertebrate chordate to the vertebrate and provides a series of verifiable predictions from a first-principles perspective.

Keywords: telencephalon; evolution; free energy principle; gene regulatory network; endogenous network theory; nonlinear process

Share and Cite

MDPI and ACS Style

Sun, C.; Yao, M.; Xiong, R.; Su, Y.; Zhu, B.; Chen, Y.-C.; Ao, P. Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation. Entropy 2024, 26, 631. https://doi.org/10.3390/e26080631

AMA Style

Sun C, Yao M, Xiong R, Su Y, Zhu B, Chen Y-C, Ao P. Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation. Entropy. 2024; 26(8):631. https://doi.org/10.3390/e26080631

Chicago/Turabian Style

Sun, Chen, Mengchao Yao, Ruiqi Xiong, Yang Su, Binglin Zhu, Yong-Cong Chen, and Ping Ao. 2024. "Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation" Entropy 26, no. 8: 631. https://doi.org/10.3390/e26080631

APA Style

Sun, C., Yao, M., Xiong, R., Su, Y., Zhu, B., Chen, Y.-C., & Ao, P. (2024). Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation. Entropy, 26(8), 631. https://doi.org/10.3390/e26080631

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Evolution of Telencephalon Anterior–Posterior Patterning through Core Endogenous Network Bifurcation

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI