Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
Abstract
:Introduction
Results and Discussion
R1 | R2 | Product | Yield(%) | M. P.( °C) |
---|---|---|---|---|
H | CH3 | 2a | 95 | 198-200 |
H | CH3CH2 | 2b | 96 | 190-191 |
H | CH3(CH2)2 | 2c | 95 | 123-125 |
H | CH3(CH2)3 | 2d | 94 | 214-216 |
H | PhCH2 | 2e | 95 | 200-201 |
CH3 | CH3 | 3a | 93 | 187-188 |
CH3 | CH3CH2 | 3b | 92 | 196-197 |
CH3 | CH3(CH2)2 | 3c | 93 | 197-198 |
CH3 | CH3(CH2)3 | 3d | 95 | 189-190 |
CH3 | PhCH2 | 3e | 96 | 174-176 |
Conclusions
Experimental
General
General procedure for the synthesis of indol-3-yl or N-methylindol-3-yl-glycines2a-e and 3a-e
Acknowledgements
References
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Ghandi, M.; Taheri, A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules 2009, 14, 1056-1061. https://doi.org/10.3390/molecules14031056
Ghandi M, Taheri A. Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water. Molecules. 2009; 14(3):1056-1061. https://doi.org/10.3390/molecules14031056
Chicago/Turabian StyleGhandi, Mehdi, and Abuzar Taheri. 2009. "Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water" Molecules 14, no. 3: 1056-1061. https://doi.org/10.3390/molecules14031056