Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
Abstract
:1. Introduction
2. Results and Discussion
Gombapyrone E (1) | Gombapyrone F (2) | |||||
---|---|---|---|---|---|---|
Position | δH mult (J, Hz) a | δC b | δH mult (J, Hz) a | δC b | ||
2 | 167.0 | C | 166.8 | C | ||
3 | 97.6 | C | 108.6 | C | ||
4 | 166.5 | C | 169.3 | C | ||
5 | 107.9 | C | 110.0 | C | ||
6 | 156.8 | C | 157.2 | C | ||
7 | 3.44 d (7.5) | 29.9 | CH2 | 3.46 d (7.5) | 29.9 | CH2 |
8 | 5.56 t (7.5) | 125.4 | CH | 5.57 t (7.5) | 125.3 | CH |
9 | 136.6 | C | 136.7 | C | ||
10 | 6.32 d (15.0) | 137.0 | CH | 6.33 d (15.0) | 137.1 | CH |
11 | 6.40 dd (15.0, 11.0) | 134.8 | CH | 6.42 dd (15.0, 11.0) | 134.9 | CH |
12 | 6.53 dd (15.0, 11.0) | 128.9 | CH | 6.49 dd (15.0, 11.0) | 128.9 | CH |
13 | 6.28 dd (15.0, 11.0) | 128.0 | CH | 6.32 dd (15.0, 11.0) | 128.1 | CH |
14 | 6.33 dd (11.0, 11.0) | 130.2 | CH | 6.36 dd (11.0, 11.0) | 130.6 | CH |
15 | 6.49 d (11.0) | 128.3 | CH | 6.58 d (11.0) | 127.9 | CH |
16 | 133.4 | C | 132.5 | C | ||
17 | 7.14 d (8.0) | 129.6 | CH | 7.11 d (8.0) | 129.6 | CH |
18 | 7.03 d (8.0) c | 126.2 | CH | 7.12 d (8.0) | 127.3 | CH |
19 | 136.8 | C | 137.0 | C | ||
20 | 7.02 s c | 129.8 | CH | 7.32 s | 126.6 | CH |
21 | 138.0 | C | 140.8 | C | ||
22 | 3.33 d | 37.3 | CH2 | 5.32 d (5.5) | 71.2 | CH |
23 | 5.90 ddt (17.0, 10.0, 6.5) | 136.9 | CH | 5.96 ddd (17.0, 10.0, 5.5) | 139.9 | CH |
24 | 4.99 ddd (10.0, 3.5, 2.0) | 114.4 | CH2 | 5.20 dt (17.0, 1.5) | 113.3 | CH2 |
4.94 ddd (17.0, 3.5, 2.0) | 5.09 dt (10.0, 1.5) | |||||
25 | 2.32 s | 19.8 | CH3 | 2.36 s | 19.9 | CH3 |
26 | 1.86 s | 11.3 | CH3 | 1.86 s | 11.3 | CH3 |
27 | 1.98 s | 8.6 | CH3 | 1.98 s | 8.8 | CH3 |
28 | 1.91 s | 7.5 | CH3 | 2.00 s | 8.7 | CH3 |
4-OCH3 | 3.87 s | 59.7 | CH3 |
Pathogen list | MIC (μg/mL) | ||
---|---|---|---|
1 | 2 | PC a | |
Escherichia coli KCTC 2593 | NA | NA | 6.25 |
Micrococcus luteus KCCM 11548 | 3.13 | 100 | 0.78 |
Staphylococcus aureus KCTC 1916 | 1.56 | NA | 0.78 |
Bacillus subtilis KCTC1021 | NA | NA | 3.13 |
Enterococcus hirae KCCM 11768 | 3.13 | 100 | 0.78 |
Staphylococcus aureus MRSA 2659 | 6.25 | NA | 12.5 |
3. Experimental
3.1. General
3.2. Strain Collection, Isolation, and Identification
3.3. Cultivation and Extraction
3.4. Isolation and Purification of Gombapyrones E (1) and F (2)
3.5. Antibacterial Activities Test
4. Conclusions
Acknowledgements
References and Notes
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Park, H.B.; Yang, H.O.; Lee, K.R.; Kwon, H.C. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules 2011, 16, 3519-3529. https://doi.org/10.3390/molecules16053519
Park HB, Yang HO, Lee KR, Kwon HC. Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002. Molecules. 2011; 16(5):3519-3529. https://doi.org/10.3390/molecules16053519
Chicago/Turabian StylePark, Hyun Bong, Hyun Ok Yang, Kang Ro Lee, and Hak Cheol Kwon. 2011. "Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002" Molecules 16, no. 5: 3519-3529. https://doi.org/10.3390/molecules16053519