Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)
Abstract
:1. Introduction
2. Results
2.1. Chemical Composition of CC-H and CC-D Fractions
2.2. Trypanocidal and Antifungal Activities of CC-H and CC-D Fractions
Compound | Peak area total ± (%) | % Match withthe data bank |
---|---|---|
2-Chlorocyclohexenol | 0.1 | 93 |
Phenylacetic acid | 0.1 | 91 |
Hexahydro-2H-azepin-2-one | 0.1 | 94 |
Tetradecanoic acid * | 1.6 | 92 |
Octadecanoic acid | 0.1 | 91 |
6,10,14-Trimethyl-2-pentadecanone | 0.5 | 94 |
3-Hydroxy-β-ionone-5,6-epoxide | 0.1 | 94 |
1,6,6-Trimethyl-7-(3-oxo-but-1-enyl)-3,8- dioxatricyclo[5.1.0.0 2,4]-octan-5-one | 0.1 | 90 |
Eicosanoic acid | 1.1 | 90 |
Hexadecanoic acid * | 17.6 | 94 |
Pentadecanoic acid * | 15.9 | 92 |
(Z)-9-Octadecenoic acid | 1.7 | 91 |
(-)-Loliolide | 0.5 | 92 |
Neophytadiene | 0.5 | 95 |
Phytol | 0.5 | 94 |
1-Octadecanol | 0.3 | 96 |
Dihydro-5-tetradecyl-2(3H)-furanone * | 0.6 | 90 |
Hexadecanamide | 0.1 | 94 |
Tetradecanamide | 0.1 | 91 |
N-Tetradecanoic acid amide | 0.1 | 90 |
Dodecanamide | 0.1 | 90 |
(Octyloxy)-benzene ** | 0.1 | 91 |
3β-Cholest-5-en-3-ol | 0.1 | 91 |
Cholesta-3,5-dien-7-one * | 0.5 | 95 |
Cholest-4-en-3-one | 0.1 | 93 |
Fractions | Cladosporium cladosporioides * Rf (potential) | Cladosporium sphaerospermum * Rf (potential) | Trypanosoma cruzi (IC50, μg/mL) | |
---|---|---|---|---|
Epimastigote form ** | Trypomastigote form *** | |||
CC-H | Origin to 0.84 ( 3) | Origin to 0.84 ( 3) | 21.7 | 858.7 |
CC-D | (i) | (i) | 19.1 | 76.2 |
CC-M | 0.40 (1) | (i) | 91.1 | 18.2 |
CC-A | 0.27 (2); 0.38 (3); 0.52 (3) | 0.27 to 0.61 (1) | 122.1 | 39.8 |
3. Discussion
3.1. Chemical Composition of CC-H and CC-D Fractions
3.2. Biological Activities of CC-H and CC-D Fractions
4. Experimental
4.1. Algal Collection
4.2. Extraction and Chromatographic Separation
4.3. GC-MS Analysis
4.4. Biological Evaluation
4.4.1. Trypanocidal Activity (Epimastigote Form)
4.4.2. Trypanocidal Activity (Trypomastigote Form)
4.4.3. Antifungal Activity
5. Conclusions
Acknowledgements
References
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Rocha, O.P.; Felício, R.D.; Rodrigues, A.H.B.; Ambrósio, D.L.; Cicarelli, R.M.B.; Albuquerque, S.D.; Young, M.C.M.; Yokoya, N.S.; Debonsi, H.M. Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta). Molecules 2011, 16, 7105-7114. https://doi.org/10.3390/molecules16087105
Rocha OP, Felício RD, Rodrigues AHB, Ambrósio DL, Cicarelli RMB, Albuquerque SD, Young MCM, Yokoya NS, Debonsi HM. Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta). Molecules. 2011; 16(8):7105-7114. https://doi.org/10.3390/molecules16087105
Chicago/Turabian StyleRocha, Otávio P., Rafael De Felício, Ana Helena B. Rodrigues, Daniela L. Ambrósio, Regina Maria B. Cicarelli, Sérgio De Albuquerque, Maria Claudia M. Young, Nair S. Yokoya, and Hosana M. Debonsi. 2011. "Chemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)" Molecules 16, no. 8: 7105-7114. https://doi.org/10.3390/molecules16087105