Thiadiazines, N,N-Heterocycles of Biological Relevance
Abstract
:1. Introduction
2. Synthesis of Tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) Derivatives
2.1. Synthesis of 3,5-Disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione (Mono-THTT)
2.2. Synthesis of Alkyl-linked-bis-(2-thioxo-[1,3,5] thiadiazinan-3-yl) carboxylic Acids (Bis-THTT)
2.3. Proposed Reaction Mechanism
2.4. Structural Characterization
3. Biological Activity of THTT Derivatives
3.1. Antiparasitic Activity
3.2. Anticancer Activity
3.3. Antibacterial and Antifungal Activity
4. Conclusions
Acknowledgments
References and Notes
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Rodríguez, H.; Suárez, M.; Albericio, F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules 2012, 17, 7612-7628. https://doi.org/10.3390/molecules17077612
Rodríguez H, Suárez M, Albericio F. Thiadiazines, N,N-Heterocycles of Biological Relevance. Molecules. 2012; 17(7):7612-7628. https://doi.org/10.3390/molecules17077612
Chicago/Turabian StyleRodríguez, Hortensia, Margarita Suárez, and Fernando Albericio. 2012. "Thiadiazines, N,N-Heterocycles of Biological Relevance" Molecules 17, no. 7: 7612-7628. https://doi.org/10.3390/molecules17077612