Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Cytotoxicity
3. Experimental
3.1. General
3.2. Synthesis
3.3. General Procedure for Amide Coupling: Preparation of 7b–k
3.4. Biological Activity Test Procedures
3.4.1. Cell Culture
3.4.2. CCK-8 for Cell Proliferation Assay
4. Conclusions
Acknowledgments
References
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Sample Availability: Samples of compounds PBDT-7a–k are available from the authors. |
S.No. | Acid (12a–k) | PBDT-7 | Time (min) | Yield (%) |
---|---|---|---|---|
1 | R = t-butyl * | 7a | 45 | 65 |
2 | R = phenyl | 7b | 20 | 80 |
3 | R = o-fluorophenyl | 7c | 30 | 75 |
4 | R = m-fluorophenyl | 7d | 30 | 80 |
5 | R = p-fluorophenyl | 7e | 30 | 75 |
6 | R = m-methoxyphenyl | 7f | 15 | 70 |
7 | R = m-cyanophenyl | 7g | 40 | 65 |
8 | R = m-chlorophenyl | 7h | 30 | 65 |
9 | R = m-trifluoromethylphenyl | 7i | 15 | 70 |
10 | R = 3′-pyridinyl | 7j | 30 | 75 |
11 | R = 2′-thiophene | 7k | 30 | 72 |
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Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772. https://doi.org/10.3390/molecules17088762
Sorra K, Chang C-F, Pusuluri S, Mukkanti K, Laiu M-C, Bao B-Y, Su C-H, Chuang T-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules. 2012; 17(8):8762-8772. https://doi.org/10.3390/molecules17088762
Chicago/Turabian StyleSorra, Kumaraswamy, Chi-Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Min-Chiau Laiu, Bo-Ying Bao, Chia-Hao Su, and Ta-Hsien Chuang. 2012. "Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives" Molecules 17, no. 8: 8762-8772. https://doi.org/10.3390/molecules17088762