Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects
Abstract
:1. Introduction
2. Results and Discussion
2.1. Extraction and Isolation
2.2. Structure Elucidation of Compounds 4, 5 and 6
2.3. Cardiovascular Effects of the Isolated Compounds
2.4. Antiplatelet Effects of Isolated Compounds
Compounds | MABP (mmHg) Basal | MABP (mmHg) After Treatment | Maximal (%) Change | HR (bpm) Basal | HR (bpm) after Treatment | Maximal (%) Change | Time Peak (s) | Time Recovery (min) |
---|---|---|---|---|---|---|---|---|
Vehicle | 141 ± 8 | 137 ± 5 | −3.1 | 422 ± 21 | 414 ± 12 | −1.8 | - | - |
5 | 138 ± 5 | 55 ± 10 ** | −60.1 ** | 290 ± 15 | 330 ± 12 * | 11.0 | 180 ± 20 | >45 |
6 | 145 ± 10 | 120 ± 12 * | −17.2 * | 405 ± 18 | 572 ± 16 ** | 41.2 | 180 ± 10 | >45 |
Losartan | 145 ± 12 | 117 ± 9 * | −19.3 * | 350 ± 32 | 447 ± 21 ** | 27.7 | 600 ± 9 | >45 |
Compounds | Aggregation (%) | ||
---|---|---|---|
AA | Collagen | ADP | |
Control | 100 | 100 | 100 |
3 | 1.2 ± 0 *** | 18.7 ± 6 ** | 40.1 ± 6 * |
4 | 49.5 ± 6 | 13.6 ± 6 *** | 90.6 ± 5 |
5 | 87.5 ± 2 | 18.5 ± 7 ** | 22.9 ± 5 ** |
6 | 89.1 ± 4 | 32.5 ± 6 * | 61.6 ± 5 |
3. Experimental Section
3.1. General Information
3.2. Plant Material
3.3. Spectral Data
3.4. Biological Assays
3.4.1. Cardiovascular Assay
3.4.2. In Vitro Platelet Aggregation Assay
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Estrada, O.; Contreras, W.; Acha, G.; Lucena, E.; Venturini, W.; Cardozo, A.; Alvarado-Castillo, C. Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects. Molecules 2014, 19, 21215-21225. https://doi.org/10.3390/molecules191221215
Estrada O, Contreras W, Acha G, Lucena E, Venturini W, Cardozo A, Alvarado-Castillo C. Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects. Molecules. 2014; 19(12):21215-21225. https://doi.org/10.3390/molecules191221215
Chicago/Turabian StyleEstrada, Omar, Whendy Contreras, Giovana Acha, Eva Lucena, Whitney Venturini, Alfonso Cardozo, and Claudia Alvarado-Castillo. 2014. "Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects" Molecules 19, no. 12: 21215-21225. https://doi.org/10.3390/molecules191221215