Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Biological Screening
2.2.1. Cell Culture and Cytotoxicity Assay
2.2.2. In Vivo Antitumor Activity of Compounds 4–6 on Growth of Solid Ehrlich Carcinoma (SEC) in Mice Model
3. Experimental
3.1. Chemistry
3.2. Synthesis of Cholesteryl Hemicarboxylate (1–3)
3.3. Preparation of 5-FU-Cholesterol Conjugates 4–6
3.4. Biological Evaluation
3.4.1. Cell Culture and Cytotoxicity Assay
3.4.2. In Vivo Antitumor Activity in Solid Ehrlich-Carcinoma-Bearing Mice (SEC)
Animals
Antitumor Evaluation
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
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Radwan, A.A.; Alanazi, F.K. Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment. Molecules 2014, 19, 13177-13187. https://doi.org/10.3390/molecules190913177
Radwan AA, Alanazi FK. Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment. Molecules. 2014; 19(9):13177-13187. https://doi.org/10.3390/molecules190913177
Chicago/Turabian StyleRadwan, Awwad A., and Fares K. Alanazi. 2014. "Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment" Molecules 19, no. 9: 13177-13187. https://doi.org/10.3390/molecules190913177