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Article

Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation

by
Hyun-Jae Jang
,
Seung-Jae Lee
,
Soyoung Lee
,
Kyungsook Jung
,
Seung Woong Lee
* and
Mun-Chual Rho
*
Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea
*
Authors to whom correspondence should be addressed.
Molecules 2017, 22(10), 1611; https://doi.org/10.3390/molecules22101611
Submission received: 25 August 2017 / Accepted: 21 September 2017 / Published: 25 September 2017
(This article belongs to the Special Issue Anti-inflammatory Agents)
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Abstract

The seeds of Alpinia katsumadai yielded two new acyclic triterpenoids, 2,3,6,22,23-pentahydroxy-2,6,11,15,19,23-hexamethyl-tetracosa-7,10,14,18-tetraene (3) and 2,3,6,22,23-pentahydroxy-2,10,15,19,23-hexamethyl-7-methylenetetracosa-10,14,18-triene (4), as well as two known compounds, 2,3,22,23-tertrahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (1) and 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (2). The absolute configurations of 2 and 3, which were determined by means of a modified Mosher’s method, are suggested as (3R; 5S; 22R) and (3R; 22R), respectively. Compounds 1–4 inhibited IL-6-induced JAK2/STAT3 activity in a dose-dependent fashion, with IC50 values of 0.67, 0.71, 2.18, and 2.99 μM. Moreover, IL-6-stimulated phosphorylation of STAT3 was significantly suppressed in U266 cells by the administration of A. katsumadai EtOH extract and Compounds 1 and 2. These results suggest that major phytochemicals, Compounds 1 and 2, obtained from A. katsumadai may be useful candidates for designing new IL-6 inhibitors as anti-inflammatory agents.
Keywords: Alpinia katsumadai; acyclic triterpenoids; IL-6; STAT3; inflammation Alpinia katsumadai; acyclic triterpenoids; IL-6; STAT3; inflammation
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MDPI and ACS Style

Jang, H.-J.; Lee, S.-J.; Lee, S.; Jung, K.; Lee, S.W.; Rho, M.-C. Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation. Molecules 2017, 22, 1611. https://doi.org/10.3390/molecules22101611

AMA Style

Jang H-J, Lee S-J, Lee S, Jung K, Lee SW, Rho M-C. Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation. Molecules. 2017; 22(10):1611. https://doi.org/10.3390/molecules22101611

Chicago/Turabian Style

Jang, Hyun-Jae, Seung-Jae Lee, Soyoung Lee, Kyungsook Jung, Seung Woong Lee, and Mun-Chual Rho. 2017. "Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation" Molecules 22, no. 10: 1611. https://doi.org/10.3390/molecules22101611

APA Style

Jang, H.-J., Lee, S.-J., Lee, S., Jung, K., Lee, S. W., & Rho, M.-C. (2017). Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation. Molecules, 22(10), 1611. https://doi.org/10.3390/molecules22101611

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