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Molecules, Volume 22, Issue 10

October 2017 - 225 articles

Cover Story: Isolation and purification of low molecular weight proteins and peptides (potential biomarkers) from biological fluids is a challenging task, since these are in very low concentration, susceptible to protease degradation and often masked by abundant proteins. Herein, novel core–shell silica nanoparticles were synthesized, and evaluated with both high and low molecular weight (LMW) model proteins/peptides. Nanoparticles hindered the entrance of high molecular weight proteins due to restrictive pores in the polymeric shell, while LMW proteins/peptides were captured by interaction with the molecular bait immobilized in the core. View this paper
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Articles (225)

  • Review
  • Open Access
29 Citations
9,184 Views
18 Pages

Pharmabiotics as an Emerging Medication for Metabolic Syndrome and Its Related Diseases

  • Thi Thanh Binh Nguyen,
  • Yan Yan Jin,
  • Hea-Jong Chung and
  • Seong-Tschool Hong

24 October 2017

Metabolic syndrome (MetS) is a cluster of metabolic risk factors associated with central obesity, hyperglycemia, insulin resistance, dyslipidemia and high blood pressure. In recent decades, because of the remarkable increase in both prevalence and se...

  • Article
  • Open Access
65 Citations
9,462 Views
18 Pages

24 October 2017

The dermaseptin peptides, mainly derived from the skin secretions of Hylidae frogs, belong to a superfamily of antimicrobial peptides and exhibit diverse antimicrobial and anticancer activities with low cytotoxicity. Here, we reported a novel dermase...

  • Article
  • Open Access
50 Citations
6,944 Views
21 Pages

24 October 2017

In this study, two Ni(II) complexes, namely [Ni(HL1)2(OAc)2] (1) and [Ni(L2)2] (2) (where HL1 and HL2 are (E)-1-((1-(2-hydroxyethyl)-1H-pyrazol-5-ylimino)methyl)-naphthalen-2-ol) and (E)-ethyl-5-((2-hydroxynaphthalen-1-yl)methyleneamino)-1-methyl-1H-...

  • Article
  • Open Access
14 Citations
5,849 Views
12 Pages

Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs

  • Wenjing Ye,
  • Qi Yao,
  • Simiao Yu,
  • Ping Gong and
  • Mingze Qin

24 October 2017

Using a highly effective binuclear Cu complex as the catalyst, the 1,3-dipolar cycloaddition reactions between 16 alkynes and two azides were successfully performed and resulted in the production of 25 new triazole-containing sorafenib analogs. Sever...

  • Article
  • Open Access
32 Citations
6,797 Views
15 Pages

Enhanced Glucose Uptake in Human Liver Cells and Inhibition of Carbohydrate Hydrolyzing Enzymes by Nordic Berry Extracts

  • Giang Thanh Thi Ho,
  • Thi Kim Yen Nguyen,
  • Eili Tranheim Kase,
  • Margey Tadesse,
  • Hilde Barsett and
  • Helle Wangensteen

24 October 2017

A Western lifestyle with low physical activity and a diet rich in sugar, fat and processed food contribute to higher incidences of diabetes and obesity. Enhanced glucose uptake in human liver cells was observed after treatment with phenolic extracts...

  • Article
  • Open Access
8 Citations
5,444 Views
23 Pages

24 October 2017

To meet the continual demands of more-sensitive immunoassays, the synthesis of novel luminescent Eu(III) chelate labels having similar substituted 4-(phenylethynyl)pyridine chromophores in three different chelate structure classes are reported. Signi...

  • Article
  • Open Access
11 Citations
5,727 Views
12 Pages

Single Actin Bundle Rheology

  • Dan Strehle,
  • Paul Mollenkopf,
  • Martin Glaser,
  • Tom Golde,
  • Carsten Schuldt,
  • Josef A. Käs and
  • Jörg Schnauß

24 October 2017

Bundled actin structures play an essential role in the mechanical response of the actin cytoskeleton in eukaryotic cells. Although responsible for crucial cellular processes, they are rarely investigated in comparison to single filaments and isotropi...

  • Article
  • Open Access
12 Citations
10,507 Views
12 Pages

Molecular Affinity of Mabolo Extracts to an Octopamine Receptor of a Fruit Fly

  • Francoise Neil D. Dacanay,
  • Ma. Carmina Joyce A. Ladra,
  • Hiyas A. Junio and
  • Ricky B. Nellas

24 October 2017

Essential oils extracted from plants are composed of volatile organic compounds that can affect insect behavior. Identifying the active components of the essential oils to their biochemical target is necessary to design novel biopesticides. In this s...

  • Article
  • Open Access
9 Citations
7,104 Views
14 Pages

24 October 2017

Equol, a metabolite of soybean isoflavone daidzein, has been proven to have various bioactivities related to human health, but little is known on its antifungal activity to plant fungal pathogens. Magnaporthe oryzae is a phytopathogenic fungus that c...

  • Article
  • Open Access
37 Citations
9,050 Views
13 Pages

GC-MS Profiling of Volatile Components in Different Fermentation Products of Cordyceps Sinensis Mycelia

  • Hongyang Zhang,
  • Yahui Li,
  • Jianing Mi,
  • Min Zhang,
  • Yuerong Wang,
  • Zhihong Jiang and
  • Ping Hu

24 October 2017

The fermentation products of Cordyceps sinensis (C. sinensis) mycelia are sustainable substitutes for natural C. sinensis. However, the volatile compositions of the commercial products are still unclear. In this paper, we have developed a simultaneou...

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Molecules - ISSN 1420-3049