Next Article in Journal
Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis
Previous Article in Journal
Antibiofilm Activity and Mechanism of Action of the Disinfectant Chloramine T on Candida spp., and Its Toxicity against Human Cells
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 22
Issue 9
10.3390/molecules22091565
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes

by
Felipe Jiménez-Aspee
1,*,
Cristina Theoduloz
2,*,
Maria Del Pilar C. Soriano
3,
Maider Ugalde-Arbizu
3,
Maria Rosa Alberto
4,
Iris Catiana Zampini
4,
Maria Inés Isla
4,
Mario J. Simirgiotis
5 and
Guillermo Schmeda-Hirschmann
3
1
Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile
2
Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile
3
Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Talca 3460000, Chile
4
Laboratorio de Investigación de Productos Naturales (LIPRON), Instituto de Química del NOA (INQUINOA, CONICET), Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán 4000, Argentina
5
Laboratorio de Productos Naturales, Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile
*
Authors to whom correspondence should be addressed.
Molecules 2017, 22(9), 1565; https://doi.org/10.3390/molecules22091565
Submission received: 25 August 2017 / Revised: 12 September 2017 / Accepted: 16 September 2017 / Published: 18 September 2017
(This article belongs to the Section Natural Products Chemistry)
Browse Figures
Versions Notes

Abstract

The native tree Geoffroea decorticans (chañar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean chañar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 μg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 μg PEE/mL) and lipase (9.9 to >100 μg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean chañar fruit contains bioactive polyphenols with functional properties.
Keywords: Geoffroea decorticans; antioxidant capacity; anti-inflammatory activity; phenolic composition; metabolic syndrome-associated enzymes; HPLC-DAD-ESI-MS Geoffroea decorticans; antioxidant capacity; anti-inflammatory activity; phenolic composition; metabolic syndrome-associated enzymes; HPLC-DAD-ESI-MS

Share and Cite

MDPI and ACS Style

Jiménez-Aspee, F.; Theoduloz, C.; Soriano, M.D.P.C.; Ugalde-Arbizu, M.; Alberto, M.R.; Zampini, I.C.; Isla, M.I.; Simirgiotis, M.J.; Schmeda-Hirschmann, G. The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes. Molecules 2017, 22, 1565. https://doi.org/10.3390/molecules22091565

AMA Style

Jiménez-Aspee F, Theoduloz C, Soriano MDPC, Ugalde-Arbizu M, Alberto MR, Zampini IC, Isla MI, Simirgiotis MJ, Schmeda-Hirschmann G. The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes. Molecules. 2017; 22(9):1565. https://doi.org/10.3390/molecules22091565

Chicago/Turabian Style

Jiménez-Aspee, Felipe, Cristina Theoduloz, Maria Del Pilar C. Soriano, Maider Ugalde-Arbizu, Maria Rosa Alberto, Iris Catiana Zampini, Maria Inés Isla, Mario J. Simirgiotis, and Guillermo Schmeda-Hirschmann. 2017. "The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes" Molecules 22, no. 9: 1565. https://doi.org/10.3390/molecules22091565

APA Style

Jiménez-Aspee, F., Theoduloz, C., Soriano, M. D. P. C., Ugalde-Arbizu, M., Alberto, M. R., Zampini, I. C., Isla, M. I., Simirgiotis, M. J., & Schmeda-Hirschmann, G. (2017). The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes. Molecules, 22(9), 1565. https://doi.org/10.3390/molecules22091565

Article Metrics

Back to TopTop