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Review

Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds

1
College of Chemistry, Jilin University, Changchun 130012, China
2
College of Plant Science, Jilin University, Changchun 130062, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2666; https://doi.org/10.3390/molecules23102666
Submission received: 13 September 2018 / Revised: 9 October 2018 / Accepted: 10 October 2018 / Published: 17 October 2018
(This article belongs to the Collection Heterocyclic Compounds)

Abstract

:
Pyrrole and its polysubstituted derivatives are important five-membered heterocyclic compounds, which exist alone or as a core framework in many pharmaceutical and natural product structures, some of which have good biological activities. The Van Leusen [3+2] cycloaddition reaction based on tosylmethyl isocyanides (TosMICs) and electron-deficient compounds as a substrate, which has been continuously developed due to its advantages such as operationally simple, easily available starting materials, and broadly range of substrates, is one of the most convenient methods to synthetize pyrrole heterocycles. In this review, we discuss the different types of two carbon synthons in the Van Leusen pyrrole reaction and give a summary of the progress of these synthesis methods in the past two decades.

1. Introduction

Pyrrole and its polysubstituted derivatives are important five-membered heterocyclic compounds, which exist alone or as a core skeleton in many pharmaceutical and natural product structures, some of them have good bioactivity such as antibacterial [1,2], antifungal [3,4], anti-inflammatory [5,6], antiviral [7], antimalarial [8], anticancer [9,10], antiparasitic [11], etc., and can also be used as enzyme inhibitor in the organism [12,13]. Some typical pyrrole derivative chemical structures and the physiological functions are summarized in the following Table 1.
Since pyrrole and its multi-substituted derivatives play an important role in organic synthesis as well as in biology, syntheses of five-membered heterocyclic pyrrole compounds have always been valued by researchers. Over the last decades, there are many methods for synthesizing pyrrole compounds in laboratory routes [14], and the classical methods include Knorr pyrrole synthesis [15], Paal-Knorr pyrrole synthesis [16], Hantzsch pyrrole synthesis [17], Barton-Zard reaction [18], Van Leusen pyrrole synthesis [19], and Piloty–Robinson pyrrole synthesis [20]. These synthesis methods are summarized in Scheme 1.
As shown in Scheme 1, the method for synthesizing pyrrole based on the [3+2] cycloaddition reaction of TosMIC as 3-atom synthon with electron-deficient olefins is also known as the Van Leusen pyrrole synthesis. It was first reported by the Van Leusen et al. in 1972. Van Leusen and co-workers used TosMICs with ester-containing double bond compounds to synthesize a series of 3,4-disubstituted pyrrole compounds under basic conditions [19]. Subsequently, they extended the substrate scope to include electron-withdrawing groups on electron-deficient olefins, such as α,β-unsaturated cyano, sulfonyl, nitro, and sulfonyl groups, which enriched the structure diversity of the resulting pyrrole compounds [21,22]. Therefore, the Van Leusen [3+2] cycloaddition reaction is one of the most convenient methods to synthetize pyrrole heterocycles, which has been continuously developed over the ensuing years due to its advantages such as operationally simple, easily available starting materials, and broad range of substrates.
TosMIC is a colorless, odorless, stable solid that can be stored at room temperature. It is an important organic synthesis intermediate, and widely used in the synthesis of five-membered nitrogen-containing heterocycles [23]. Under the Van Leusen pyrrole synthesis reaction conditions, TosMIC loses a proton to form a carbanion under the action of a base because of the electron-withdrawing effect of the sulfone and isocyanide. The carbon anion attacks on the α,β-unsaturated compound, undergoes an intramolecular [3+2] cycloaddition reaction, and causes the leaving of the tosyl group to form the final heterocyclic compound. The mechanism of [3+2] cycloaddition reaction between TosMICs and electron-deficient alkenes to form pyrrole derivatives is shown in Scheme 2.
In recent reports, it has been found that this reaction occurs selectively at the position of a less polar double bond. The use of electron-deficient compounds having an electron-withdrawing group and a relatively stable structure, or a solvation effect in the reaction system to stabilize the structure of the electron-deficient compound, can significantly increase the rate and yield of the reactions.
In this paper, we review the research progress of the synthesis of pyrrole derivatives through the [3+2] cycloaddition reaction between TosMICs and different kinds of 2-carbon synthons based on the Van Leusen pyrrole synthesis method in the past two decades.

2. Synthesis of Pyrrole Derivatives by [3+2] Cycloaddition of TosMICs with Alkenes

In 1972, Van Leusen and co-workers firstly reported that TosMICs can react with electron-deficient alkenes under basic conditions to produce 3-substituted pyrrole derivatives [19]. They found that there are [3+2] cycloadditions occurring in alkenes with different electron-withdrawing groups. As shown in Scheme 3, the electron-withdrawing groups may be esters, amides, ketones, nitros, cyanos, aryls, etc. [24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60]. Based on the different types of electron-withdrawing group attached to the alkenes, they are classified and described in order (Scheme 3).

2.1. Alkenes with an Ester Group

As early as in the 1990s, Van Leusen and co-workers developed a process in which TosMIC 16 reacts with a Michael acceptor to form 3,4-disubstituted pyrrole compounds 17 or 3-substituted pyrrole compounds 18. This procedure necessarily installs the activating Z group of the Michael acceptor at the 3-position of the pyrrole ring formed (Scheme 4) [22,24].
In 1997, the Trudell group described an expeditious method for the synthesis of 3-aryl-substituted pyrroles. The 3-arylpyrroles 22 were prepared in a short reaction sequence from the readily available aryl aldehydes 19. The aldehydes 19 were converted into the corresponding methyl 3-arylacrylate esters 20 using a Wadsworth-Emmons olefination procedure. Treatment of 20 with TosMIC 16 afforded the 4-aryl-3-(methoxycarbonyl)-pyrroles 21. Then the ester moieties were hydrolyzed to the corresponding carboxylic acids with excess KOH in 50% MeOH. The acid derivatives were then decarboxylated by heating in 2-ethanolamine to give the 3-arylpyrroles 22 in good yield (Scheme 5) [25].
The electron neutral or electron-deficient aryl vinyl esters such as cinnamic acid esters could be successfully employed in the cyclization reaction. However, the TosMIC 16 addition reaction with 20 which possessed electron-rich substituents on the aryl ring did not yield the desired pyrroles, but rather gave intractable mixtures.
The next year, Di Santo et al. pioneered the synthesis of 2H-pyrrolo[3,4-b][1,5]pyrrolo-benzothiazepine 27. They started with tetrabutylammonium fluoride (TBAF)-catalyzed reaction of 2-nitrothiophenol 23 with ethyl 2-propynoate to afford ethyl 3-(2-nitrophenylthio)propenoate 24. Then they performed a transformation of the sulfur derivative into the sulfone analogue by the use of m-chloroperbenzoic acid (MCPBA). Afterwards, the novel E/Z mixture 25 was reacted with TosMIC 16 to form ethyl 4-(2-nitrophenylsulfony1)-1H-pyrrole-3-carboxylate 26 as the sole product. 2H-pyrrolo[3,4-b][1,5]pyrrolobenzothiazepine 27 can be synthesized by using compound 26 as raw material (Scheme 6) [26].
In 2007, Krishna’s group found that aldehyde 28 on treatment with (ethoxycarbonylmethylene)-triphenylphosphorane in refluxing benzene was converted to the α,β-unsaturated ester 29 (72%), and treatment of 29 with potassium salt of TosMIC 16 afforded the corresponding pyrrole C-nucleosides 30a (36%) and 30b (32%) (Scheme 7) [27].
In 2008, Shin’s group developed a synthesis of ethyl 4-substituted-1H-pyrrole-3-carboxylates 33 from aldehyde 31, in which they synthesized α,β-unsaturated ester 32 from aromatic or aliphatic aldehydes by the Horner-Wadsworth-Emmons reaction and subsequently reacted it with TosMIC 16 in the presence of sodium t-amylate in toluene. In this reaction, the solvent, toluene, can be used in both reaction and crystallization, which makes it more practical and greener (Scheme 8) [28].
Hu’s group developed a procedure for the preparation of N-arylated 3,4-disubstituted pyrroles 35 from alkenes in the same year. They found that these compounds can be obtained when a mixture of ethyl 3-phenylacrylate 34, TosMIC 16, PhI, CuI, and 1,10-phenanthroline in toluene was treated with 3.0 equivalents of base at −30 °C for 10 min and then the resultant mixture was refluxed until the intermediate was completely exhausted. When a (1:2) mixture of t-BuONa to Cs2CO3 was used as base, 35 was obtained as a single product. In this procedure, t-BuONa served as a base for Van Leusen pyrrole synthesis and Cs2CO3 for the N-arylation, respectively (Scheme 9) [29].
In 2009, Poulard et al. designed a synthetic route for 3,4-disubstituted pyrrole compounds 40, in which the 1,2-disubstituted Michael acceptors 38 are prepared by cross-methylation with compounds 36 and 37 that were used to react with TosMIC 16 to obtain 40. Under the same conditions, compounds 41 can be also obtained when the R2 group was the ketone carbonyl-substituted Michael acceptor 39 (Scheme 10) [30].
In the same year, the Sánchez-García group reported that 2,2′-bipyrroles compounds 43 were synthesized through the reaction of enesters 42 and TosMIC 16. 2,7,12,17-tetraarylporphycenes 44 can be synthesized by using compounds 43 as raw materials. Porphycenes are of great value in the chemical industry and in biomedicine. During this reaction, there will also be a monopyrrole product formed, but if post-treated with dilute ammonia, the bipyrrole compound can be precipitated in ethyl acetate (Scheme 11) [31].
In 2012, Di Santo et al. described the formation of a pyrrole derivative 46 from (E)-ethyl-3-(2-nitrophenyl)acrylate 45 and TosMIC 16 under basic conditions. Then, nitro reduction and intramolecular cyclization into a lactam were further performed to synthesize 2H-pyrrolo[3,4-c]quinoline compound 47 (Scheme 12) [32].
In 2014, the Ji group found that 2-aminoaryl acrylate 48 and TosMIC 16 undergo [3+2] cycloaddition under basic condition and could effectively synthesize pyrrolo[3,4-c]quinolinone 49 or pyrrolo[3,4-c]quinolines 50. It is worth mentioning that the reacted pyrrole intermediate will both undergo an intramolecular condensation reaction of the ester or ketone with the amine during the formation of the quinoline ring. The reactions have good efficiency and practicality, and the yields can reach up to 73% (Scheme 13) [33].
In 2015, our group developed an expedient and divergent tandem one-pot synthesis of benz[e]indole derivative 53 (79%) and spiro[indene-1,3’-pyrrole] derivative 54 (6%) from alkyne-tethered chalcones/cinnamates 51 and TosMIC 16. The formation of intermediate 52 in this reaction involves a [3+2] cycloaddition with TosMIC 16 and electron-deficient ester 51 (Scheme 14) [34]. To our knowledge this reaction is the first example of intramolecular electrophilic cyclizations of alkynes with in-situ generated pyrroles.
In 2018, the Lamberth group reported a new synthesis route of pyrrolocarboxamide compounds 57. They firstly used diethyl maleate 55 as starting material, which was converted with TosMIC 16 into the 3,4-dicarbethoxy-substituted pyrrole 56. Then, after a series of reactions on the substituents, pyrrole carboxamide compound 57 was synthesized (Scheme 15) [35].

2.2. Alkenes with an Amide Group

Donohoe and co-workers continued to expand the reaction to TosMIC 16 with acrylic acid pyrrolidide 58 to generate two pyrroles in reasonable yields in 1998. The compound was subsequently protected under standard conditions to yield the N-Boc pyrrole 60. Under the similar conditions, N-Adoc pyrrole 61 could be obtained from cyclohexyl acrylate 59 and TosMIC 16, respectively (Scheme 16) [36].
In 2011, Padmavathi et al. condensed cinnamoyl chloride 63 with an aromatic heterocyclic compound 62 containing an amino group to prepare a series of aromatic heterocyclic cinnamic acid amide compounds 64. Then, these electron-deficient alkenes were reacted with TosMIC 16 in the presence of NaH, DMSO and diethyl ether to prepare a series of 4′-phenyl-N-(4-heteroaryl-2-yl)-1′H-pyrrole-3′-carboxamide compounds 65. According to a bioassay, compounds 65 have certain antibacterial activity against Gram-negative bacteria, and most of the compounds have the effect of inhibiting spore germination (Scheme 17) [37].
In 2017, Adivireddy et. al. developed a synthesis of pyridinylcarbamoylmethyl pyrrolyl compounds 69. In this route, the synthetic intermediate (E)-N-((4-(aryl)-3-cyano-6-(aryl)pyridin-2-ylcarbamoyl)methyl)cinnamamide 68 was prepared by the condensation of 2-amino-4,6-diaryl-pyridine-3-carbonitrile 66 with 2-(cinnamamido)acetic acid 67 in the presence of o-(7-azabenzo-triazol-1-yl)-N,N,N,N-tetramethyluraniumhexafluorophosphate (HATU) and N,N-diisopropyl-ethylamine (DIPEA) in DMF under ultrasonication at room temperature. Then occurs the reaction of 68 with TosMIC 16 in the presence of NaH and in a solvent mixture of ether and dimethylsulfoxide (2:1) produced N-((4-(aryl)-3-cyano-6-(aryl) pyridin-2-ylcarbamoyl)methyl)-4-phenyl-1H-pyrrole-3-carboxamide 69. The bis amido linked aromatized heterocycles pyrrolyl pyridines 69 exhibited excellent radical scavenging activity (Scheme 18) [38].

2.3. Alkenes with a Keto Group

In 2000, Dannhardt and co-workers reported that 1,3-diarylprop-2-en-1-ones 70 and TosMIC 16 were dissolved in THF as solvent to produce 3-aroyl-4-arylpyrroles 71 in the presence of NaH at room temperature for 0.5 h. Then compounds 71 were alkylated at the pyrrole nitrogen to afford an N-substituted aryl-aroyl-pyrroles 72 (Scheme 19) [39].
The [3+2] cycloaddition of TosMIC with unsymmetrically substituted divinyl ketones occurs selectively on the less polar double bond. In 2007, the Rao group found that TosMIC 16 and cinnamoylketene dithioacetal 73 can selectively synthesize 3,3-bis(methylthio)-1-(4-aryl-1H-pyrrol-3-yl)prop-2-en-1-one 74 via [3+2] cycloaddition. This reaction occurs selectively on the less polar 4-position ene bond (Scheme 20) [40].
In the same year, Terzidis et al. reported that chromone-3-carboxaldehydes 75 were allowed to react with equimolar amounts of TosMIC 16 in the presence of DBU, in the aprotic nonpolar solvent THF at room temperature. As a result 2-tosyl-4-(2-hydroxybenzoyl)pyrroles 76 were isolated in good yield (Scheme 21) [41].
In 2009, the Pérez group synthetized a series of pyrrole derivatives 78 by using TosMIC 16 with α,β-unsaturated carbonylic compounds 77, which were obtained through Claisen-Schmidt condensation from the respective acetophenones and benzaldehydes substituted in m-position (Scheme 22) [42].
In 2012, Kelly et al. found that the cyclic α,β-unsaturated ketone 79 can be used as a Michael acceptor for 1,3-dipolar cycloaddition to form pyrrole. The 3,4-fused cycloalkanopyrroles 80 were synthesized by reaction of 79 with TosMIC 16 and sodium hydride in a 3:1 solution of diethyl ether and dimethyl sulfoxide at room temperature, but the yield of the cyclization appeared to depend on the base-sensitivity of the Michael acceptor (Scheme 23) [43].
Similar reactions can occur with TosMIC derivatives. In 2013, the Ji group reported the reaction of TosMIC 16 with (Z)-3-(2-oxo-2-ethylidene)indolin-2-one derivatives 81 to give pyrrole derivatives 82, and developed a simple and convenient synthetic approach to access of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives 83 by the reaction of 81 with functionalized TosMIC derivatives 16 under basic conditions (Scheme 24) [44].
In the following year, Ji et al. also discovered a method for synthesizing bridged 3,3′-dipyrrole derivatives 85 by the reaction of dienone derivatives 84 with TosMIC 16. In addition to the classical [3+2] cycloaddition reaction, this reaction also involves C-C bond cleavage caused by traces of water in the system. They also captured a spirocyclic intermediate, which is providing a new idea for the study of the construction of bispirocyclic compounds by isonitrile (Scheme 25) [45].
In 2016, our group described a silver-catalyzed tandem reaction of TosMIC derivatives 16 with 2-methyleneindene-1,3-diones 86 to produce benzo[f]indole-4,9-diones compounds 87. The reaction undergoes a domino [3+2]-cycloaddition/imidoyl anion cyclization/ring opening of cyclo-propanolate/aromatization and three C-C bonds are formed successively. The pyrrole ring is constructed while expanding a carbon atom to the original carbon ring (Scheme 26) [46].
In 2017, Mao and co-workers reported a synthesis of 4-substituted thienyl pyrrole compounds 90 via Vilsmeier-Haack formylation, aldol condensation and Van Leusen pyrrole synthesis using 2-methoxythiophene 88 as starting material. Compounds 90 have good selectivity and inhibition to tumor cells (Scheme 27) [47].
In 2017, Shanmugam et al. described that chalcone 91 and TosMIC 16 undergo [3+2] cycloaddition under mild conditions to synthesize 3-aroyl-4-arylpyrrole compounds 92. A new substituted carbamoylpyrrole 93 exhibiting moderate antibacterial activity against gram-positive bacteria and gram-negative bacteria was then synthesized by a substitution reaction with methyl iodide (Scheme 28) [48].
Solvation or dynamic solvent effects can affect the rate of [3+2] cycloaddition reaction between TosMIC and aromatic ketones. In 2013, Nair’s group discovered a lithium hydroxide mediated 3,4-disubstituted pyrrole synthesis method [49]. As shown in Scheme 29, acetophenone 94 was reacted with benzaldehyde 95 in the presence of LiOH·H2O in ethanol medium to afford 1,3-diphenylprop-2-enone 96 by an aldol condensation between the enolate and the electrophile. Then, TosMIC 16 and an additional equivalent of LiOH·H2O were added to the same system. As the reaction progressed, a white solid precipitated from the reaction medium, the product obtained was filtered, washed with water and ethanol, and characterized as phenyl(4-phenyl-1H-pyrrol-3-yl)methanone 97. In this reaction system, due to the small size of Li+ ion, LiOH·H2O has obvious covalent character, which slows down the release of OH-. At the same time, a solvation effect occurs in the polar solvent to increase the yield.
A plausible mechanism for the reaction is depicted in Scheme 30. LiOH·H2O abstracts a proton from the methylene group of TosMIC to generate a carbanion which can be stabilized by the sulfonyl group. The intermediate 1,3-dipole undergoes [3+2] cycloaddition reaction to provide the cycloadduct 100. Elimination of lithium p-toluenesulfinate under the action of a base to produce a C-3 substituted pyrrole derivative 101. Finally, 1,3-hydride shift occurs to afford the product 97. The β-substituent of the electrophile ends up at the C-4 position of the pyrrole ring.
In 2016, Nair and co-workers also reported an aroyl-substituted pyrroles 105 synthetic route from phosphonium salt 102 as starting material. The phosphonium salt was neutralized with aqueous NaOH and extracted with dichloromethane to afford 1-phenyl-2-(triphenyl-phosphoranylidene)ethenone 103. Further the compound was reacted with isobutyraldehyde in dichloromethane to generate the corresponding α,β-unsaturated ketone 104. Upon completion of the reaction, dichloromethane was evaporated and the reaction mixture was triturated with hexane to remove triphenylphosphine oxide. Moreover, they found that LiOH·H2O gave good yields of the desired product as compared to NaOH and KOH. This might be due to better coordination power of lithium (Scheme 31) [50].
Multi-component Van Leusen pyrrole synthesis can also occur in alkenes with aromatic ketones. In 2014, the Shanmugam research group found that cinnamoylketene dithioacetal 106 undergo multi-component cycloaddition with TosMIC 16, guanidine nitrate 107 and alkyl alcohol 108 in the presence of NaH/THF to furnish the target 6-pyrrolylpyrimidines 109 in excellent yields of 70–97% (Scheme 32) [51]. Because of the electron donating characteristics of the two methyl sulfanyl groups and the structural features of α,β-unsaturated carbonyl group, the arylvinyl double bond is more polarized than the ketene acetal double bond, which causes TosMIC 16 to selectively react at the arylvinyl double bond.

2.4. Alkenes with a Nitro Group

In 2009, Xiaoqi Yu and co-workers reported that 4(3)-substituted 3(4)-nitro-1H-pyrrole 111 can be synthesized from nitroene 110 and TosMIC 16 in the presence of the ionic liquid 1-butyl-3-methylimidazolium bromide ([bmIm]Br). This reaction can be widely applied to aromatic, aliphatic or heterocyclic substituted nitroolefins, and the recovered ionic liquid can be repeatedly used as a solvent without significantly reducing the yield (Scheme 33) [52].

2.5. Alkenes with a Cyano Group

In 2012, the Yongping Yu group reported that two equivalents of a cyano-substituted trisubstituted alkene 112 and TosMIC 16 were dissolved in anhydrous acetonitrile as a solvent and reacted in the presence of NaH at room temperature for 3 h to form disubstituted pyrrole derivatives 113. And the 1,3’-bipyrrole 114 is obtained if the reaction time is extended to 12 h (Scheme 34) [53,54]. In the experiments, researchers also found that when keto and ester groups are simultaneously present in alkenes, due to the higher reactivity, keto group can be eliminated more easily than ester groups alone. In addition, group with larger steric hindrance can reduce the reactivity when they are present on alkenes.

2.6. Alkenes with an Aryl Group

In 2002, Smith and co-workers developed a method for the one-step synthesis of 3-aryl and 3,4-diarylpyrroles 116 with good yields by readily available aryl or diaryl alkenes 115 with TosMIC 16 (Scheme 35) [55]. They found that the stronger the electron-withdrawing ability of the aryl group attached to the alkene in the substrate, the lower the temperature required for the reaction, the shorter the reaction time, and the higher yield. At the same time, the steric hindrance of the aryl group will act as a deterrent to the reaction. This phenomenon is particularly evident when the aryl group is ortho-substituted.

2.7. Other Alkene Synthons

Magnus et al. reported the effect of metal ion on the conjugate addition of TosMIC 16 anions to ethyl sorbate 117 in 1987. The sodium salt of TosMIC 16 in DMSO:ether reacted with 117 to afford pyrrole 118 (pathway a) in 80% yield, whereas the lithium salt of TosMIC 16 in THF afforded the addition adduct 119 in 61% yield (pathway b) (Scheme 36, left) [56]. On the basis of the research, Ganem and co-workers reported that condensation of 117 with the sodium anion of TosMIC in DMSO: ether gave regioisomers 120 in 1997. While using LiN(TMS)2 in THF at −78 °C, pyrrole derivate 121 was obtained as the only detectable product. The combination of more polar solvent and more highly dissociated anion favored reaction at the terminally polarized δ-position of dienoate 117, leading to the desired 1,6-addition product (Scheme 36, right) [57].
Quinone can be also used for the Van Leusen pyrrole synthesis. In 1996, Di Santo et al. reported a synthesis of 2H-benz[f]isoindole-4,9-dione 123 from TosMIC 16 that reacts with Michael acceptor 1,4-naphthoquinone 122. N-Methylation of the latter compound with iodomethane in the presence of anhydrous potassium carbonate afforded 2-methyl-2H-benz[f]isoindole-4,9-dione 124 (Scheme 37) [58].
In 2012, Yongping Yu and co-workers reported synthesis of polysubstituted pyrroles 126 from TosMIC 16 and vinyl azides 125 under mild conditions in the presence of base (Scheme 38) [59]. Additionally, they developed a Van Leusen three-component reaction as a synthesis of 2,3,4-trisubstituted pyrrole 129, where a mixture of 3-nitrobenzaldehyde 127 and ethyl 2-azidoacetate 128 was stirred under the Knoevenagel condensation conditions using NaH as the base for 2 h at −15 °C, followed by addition of TosMIC 16. The reaction mixture was then stirred at room temperature for 24 h to give the desired product 129 (Scheme 39) [59].
In 2017, our research group discovered that TosMIC 16 can undergo a [3+2] cycloaddition reaction with a styrylisoxazole compounds 130 to construct a series of 3-isoxazole disubstituted pyrrole derivatives 131 (Scheme 40) [60]. Under the same optimized reaction condition, the synthesis of the 3-isoxazole trisubstituted pyrrole derivatives 132 was achieved by using the TosMIC derivatives 16 (Scheme 41) [60]. This transformation is operationally simple, high-yielding, and displays broad substrate scope.

3. Synthesis of Pyrrole Derivatives by [3+2] Cycloaddition of TosMICs with Alkynes

Similar to alkenes, alkynes can also undergo [3+2] cycloaddition with TosMIC to synthesize pyrrole derivatives. As early as in 1979, Saikachi and co-workers found that acetylene ester 133 (2 equiv each) and TosMIC 16 can produce 2,3,4-trisubstituted pyrrole compounds 134 in the presence of DBU. The 1,2,3,4-tetrasubstituted pyrrole compounds 135 can be synthesized by another one-step addition reaction (Scheme 42) [61].
In 2006, Alizadeh et al. found that dialkyl acetylenedicarboxylates 136 react with TosMIC 16 in the presence of Ph3P to form dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4-dicarboxylates 137. In this reaction, the nucleophilic addition of Ph3P to the acetylenic esters further increases the reactivity of the substrate as an electron-withdrawing group (Scheme 43) [62].
In 2011, the Adib group developed a protocol that is different with respect to the common shortcomings such as long reaction time, low yield, expensive raw materials, and harsh reaction conditions. A mixture of TosMIC 16, and a dialkyl acetylenedicarboxylate 138, in the presence of a catalytic amount of 1-methylimidazole 139 undergoes a smooth addition reaction in anhydrous CH2Cl2 at room temperature to afford 2,3,4-trisubstituted pyrroles 140 in yields of 90–95% (Scheme 44) [63].

4. Conclusions

In summary, the Van Leusen [3+2] cycloaddition reaction based on TosMICs and electron-deficient compounds is involved in the construction of pyrrole and its derivatives because of its advantages such as simple and convenient synthesis substrate, diverse products, etc., and will play an increasingly important role in the synthesis of bioactive pyrrole derivatives in the pharmaceutical synthesis. In recent years, some research progress has been made, which provides new ideas for the synthesis of polysubstituted pyrrole ring framework. In the future, there will be a focus on developing more types and higher selectivity 2-carbon synthons in subsequent research to increase the expansion of the reaction.

Author Contributions

All authors wrote the paper. All authors read and approved the final manuscript.

Funding

Financial support of this research provided by Science and Technology Planning Project of Jilin Province (20160414015GH) is greatly acknowledged.

Conflicts of Interest

The authors declare no conflict of interest.

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Scheme 1. Typical cycloaddition methods for pyrrole heterocycle and its derivatives.
Scheme 1. Typical cycloaddition methods for pyrrole heterocycle and its derivatives.
Molecules 23 02666 sch001
Scheme 2. Mechanism of pyrrole compounds formed by [3+2] cycloaddition between TosMICs and electron-deficient alkenes.
Scheme 2. Mechanism of pyrrole compounds formed by [3+2] cycloaddition between TosMICs and electron-deficient alkenes.
Molecules 23 02666 sch002
Scheme 3. Synthetic protocols for polysubstituted pyrroles from TosMICs and electron-defect alkenes.
Scheme 3. Synthetic protocols for polysubstituted pyrroles from TosMICs and electron-defect alkenes.
Molecules 23 02666 sch003
Scheme 4. Synthesis of 3, 4-substituted and 3-disubstituted pyrrole compounds 17 and 18.
Scheme 4. Synthesis of 3, 4-substituted and 3-disubstituted pyrrole compounds 17 and 18.
Molecules 23 02666 sch004
Scheme 5. Synthesis of 3-arylpyrroles 22.
Scheme 5. Synthesis of 3-arylpyrroles 22.
Molecules 23 02666 sch005
Scheme 6. Synthesis of 2H-pyrrolo[3,4-b][1,5]pyrrolobenzothiazepine 27.
Scheme 6. Synthesis of 2H-pyrrolo[3,4-b][1,5]pyrrolobenzothiazepine 27.
Molecules 23 02666 sch006
Scheme 7. Synthesis of pyrrole C-nucleosides 30a and 30b.
Scheme 7. Synthesis of pyrrole C-nucleosides 30a and 30b.
Molecules 23 02666 sch007
Scheme 8. Synthesis of ethyl 4-substituted-1H-pyrrole-3-carboxylate 33.
Scheme 8. Synthesis of ethyl 4-substituted-1H-pyrrole-3-carboxylate 33.
Molecules 23 02666 sch008
Scheme 9. Synthetic route of N-arylated 3,4-disubstituted pyrrole 35.
Scheme 9. Synthetic route of N-arylated 3,4-disubstituted pyrrole 35.
Molecules 23 02666 sch009
Scheme 10. Synthesis of 3,4-disubstituted pyrrole compounds 40 and 41.
Scheme 10. Synthesis of 3,4-disubstituted pyrrole compounds 40 and 41.
Molecules 23 02666 sch010
Scheme 11. Synthesis of 2,2’-bipyrrole compounds 43.
Scheme 11. Synthesis of 2,2’-bipyrrole compounds 43.
Molecules 23 02666 sch011
Scheme 12. Synthetic route of pyrrole derivative 47.
Scheme 12. Synthetic route of pyrrole derivative 47.
Molecules 23 02666 sch012
Scheme 13. Synthesis of pyrrolo[3,4-c]quinolinone 49 and pyrrolo[3,4-c]quinolines 50.
Scheme 13. Synthesis of pyrrolo[3,4-c]quinolinone 49 and pyrrolo[3,4-c]quinolines 50.
Molecules 23 02666 sch013
Scheme 14. Synthesis of benz[e]indole derivative 53 and spiro[indene-1,3’-pyrrole] derivative 54.
Scheme 14. Synthesis of benz[e]indole derivative 53 and spiro[indene-1,3’-pyrrole] derivative 54.
Molecules 23 02666 sch014
Scheme 15. Synthesis of pyrrole carboxamide compound 57.
Scheme 15. Synthesis of pyrrole carboxamide compound 57.
Molecules 23 02666 sch015
Scheme 16. Synthesis of N-Boc pyrrole 60 or N-Adoc pyrrole 61.
Scheme 16. Synthesis of N-Boc pyrrole 60 or N-Adoc pyrrole 61.
Molecules 23 02666 sch016
Scheme 17. Synthesis of 4′-phenyl-N-(4-heteroaryl-2-yl)-1′H-pyrrole-3′-carboxamide compounds 65.
Scheme 17. Synthesis of 4′-phenyl-N-(4-heteroaryl-2-yl)-1′H-pyrrole-3′-carboxamide compounds 65.
Molecules 23 02666 sch017
Scheme 18. Synthesis of pyridinylcarbamoylmethyl pyrrolyl compounds 69.
Scheme 18. Synthesis of pyridinylcarbamoylmethyl pyrrolyl compounds 69.
Molecules 23 02666 sch018
Scheme 19. Synthesis of 3-aroyl-4-arylpyrroles 71 and N-substituted aryl-aroyl-pyrroles 72.
Scheme 19. Synthesis of 3-aroyl-4-arylpyrroles 71 and N-substituted aryl-aroyl-pyrroles 72.
Molecules 23 02666 sch019
Scheme 20. Synthesis of 3, 3-bis(methylthio)-1-(4-aryl-1H-pyrrol-3-yl)prop-2-en-1-one compound 74.
Scheme 20. Synthesis of 3, 3-bis(methylthio)-1-(4-aryl-1H-pyrrol-3-yl)prop-2-en-1-one compound 74.
Molecules 23 02666 sch020
Scheme 21. Synthesis of 2-tosyl-4-(2-hydroxybenzoyl)pyrroles 76.
Scheme 21. Synthesis of 2-tosyl-4-(2-hydroxybenzoyl)pyrroles 76.
Molecules 23 02666 sch021
Scheme 22. Synthetic route of pyrrole derivatives 78.
Scheme 22. Synthetic route of pyrrole derivatives 78.
Molecules 23 02666 sch022
Scheme 23. Synthesis of 3,4-fused cycloalkanopyrroles 80.
Scheme 23. Synthesis of 3,4-fused cycloalkanopyrroles 80.
Molecules 23 02666 sch023
Scheme 24. Synthesis of disubstituted pyrroles 80 and 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives 83.
Scheme 24. Synthesis of disubstituted pyrroles 80 and 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives 83.
Molecules 23 02666 sch024
Scheme 25. Synthesis of bridged 3,3′-dipyrrole derivatives 85.
Scheme 25. Synthesis of bridged 3,3′-dipyrrole derivatives 85.
Molecules 23 02666 sch025
Scheme 26. Synthesis of benzo[f]indole-4,9-diones compounds 87.
Scheme 26. Synthesis of benzo[f]indole-4,9-diones compounds 87.
Molecules 23 02666 sch026
Scheme 27. Synthesis of 4-substituted thienyl pyrrole compounds 90.
Scheme 27. Synthesis of 4-substituted thienyl pyrrole compounds 90.
Molecules 23 02666 sch027
Scheme 28. Synthesis of 3-aroyl-4-arylpyrrole compounds 93.
Scheme 28. Synthesis of 3-aroyl-4-arylpyrrole compounds 93.
Molecules 23 02666 sch028
Scheme 29. Synthesis of phenyl(4-phenyl-1H-pyrrol-3-yl)methanone 97.
Scheme 29. Synthesis of phenyl(4-phenyl-1H-pyrrol-3-yl)methanone 97.
Molecules 23 02666 sch029
Scheme 30. A plausible mechanism for the [3+2] cycloaddition reaction for TosMIC with LiOH·H2O.
Scheme 30. A plausible mechanism for the [3+2] cycloaddition reaction for TosMIC with LiOH·H2O.
Molecules 23 02666 sch030
Scheme 31. Synthesis of aroyl-substituted pyrroles 105.
Scheme 31. Synthesis of aroyl-substituted pyrroles 105.
Molecules 23 02666 sch031
Scheme 32. Synthesis of 6-pyrrolylpyrimidines 109.
Scheme 32. Synthesis of 6-pyrrolylpyrimidines 109.
Molecules 23 02666 sch032
Scheme 33. Synthesis of 4(3)-substituted 3(4)-niropyrrole 111.
Scheme 33. Synthesis of 4(3)-substituted 3(4)-niropyrrole 111.
Molecules 23 02666 sch033
Scheme 34. Synthesis route of 3,4-disubstituted pyrrole derivatives 113 and 1,3’-bipyrrole compound 114.
Scheme 34. Synthesis route of 3,4-disubstituted pyrrole derivatives 113 and 1,3’-bipyrrole compound 114.
Molecules 23 02666 sch034
Scheme 35. Synthesis of 3-aryl and 3,4-diaryl-(1H)-pyrroles 116.
Scheme 35. Synthesis of 3-aryl and 3,4-diaryl-(1H)-pyrroles 116.
Molecules 23 02666 sch035
Scheme 36. The effect of metal ion on the conjugate addition of TosMIC 16 anions to ethyl sorbate 117.
Scheme 36. The effect of metal ion on the conjugate addition of TosMIC 16 anions to ethyl sorbate 117.
Molecules 23 02666 sch036
Scheme 37. Synthesis of 2-methyl-2H-benz[f]isoindole-4,9-dione 124.
Scheme 37. Synthesis of 2-methyl-2H-benz[f]isoindole-4,9-dione 124.
Molecules 23 02666 sch037
Scheme 38. Synthesis of polysubstituted pyrroles 126.
Scheme 38. Synthesis of polysubstituted pyrroles 126.
Molecules 23 02666 sch038
Scheme 39. Synthesis of 2,3,4-trisubstituted pyrrole 129.
Scheme 39. Synthesis of 2,3,4-trisubstituted pyrrole 129.
Molecules 23 02666 sch039
Scheme 40. Synthesis of 3-isoxazole disubstituted pyrroles derivatives 131.
Scheme 40. Synthesis of 3-isoxazole disubstituted pyrroles derivatives 131.
Molecules 23 02666 sch040
Scheme 41. Synthesis of 3-isoxazole trisubstituted pyrrole derivatives 132.
Scheme 41. Synthesis of 3-isoxazole trisubstituted pyrrole derivatives 132.
Molecules 23 02666 sch041
Scheme 42. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 134 and 1,2,3,4-tetrasubstituted pyrrole derivatives 135.
Scheme 42. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 134 and 1,2,3,4-tetrasubstituted pyrrole derivatives 135.
Molecules 23 02666 sch042
Scheme 43. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 137.
Scheme 43. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 137.
Molecules 23 02666 sch043
Scheme 44. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 140.
Scheme 44. Synthesis of 2,3,4-trisubstituted pyrrole derivatives 140.
Molecules 23 02666 sch044
Table 1. Some typical pyrrole derivative chemical structures and the physiological functions.
Table 1. Some typical pyrrole derivative chemical structures and the physiological functions.
Physiological FunctionsChemical StructuresReferences
Antibacterial Molecules 23 02666 i001 Molecules 23 02666 i002[1,2]
Antifungal Molecules 23 02666 i003 Molecules 23 02666 i004[3,4]
Anti-inflammatory Molecules 23 02666 i005 Molecules 23 02666 i006[5,6]
Antiviral Molecules 23 02666 i007 Molecules 23 02666 i008[7]
Antimalarial Molecules 23 02666 i009[8]
Anticancer Molecules 23 02666 i010 Molecules 23 02666 i011[9,10]
Antiparasitic Molecules 23 02666 i012 Molecules 23 02666 i013[11]
Enzyme inhibitor Molecules 23 02666 i014 Molecules 23 02666 i015[12,13]

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Ma, Z.; Ma, Z.; Zhang, D. Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds. Molecules 2018, 23, 2666. https://doi.org/10.3390/molecules23102666

AMA Style

Ma Z, Ma Z, Zhang D. Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds. Molecules. 2018; 23(10):2666. https://doi.org/10.3390/molecules23102666

Chicago/Turabian Style

Ma, Zhengning, Zicheng Ma, and Dawei Zhang. 2018. "Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds" Molecules 23, no. 10: 2666. https://doi.org/10.3390/molecules23102666

APA Style

Ma, Z., Ma, Z., & Zhang, D. (2018). Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds. Molecules, 23(10), 2666. https://doi.org/10.3390/molecules23102666

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