K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Sample Availability: Not available. |
Entry | Oxidant (Equiv) | Concentration of H2O (M) | Yield (%) b |
---|---|---|---|
1 | BPO (2) | 14 | 58 |
2 | BQ (2) | 14 | 0 |
3 | DTBP (2) | 14 | <5 |
4 | TBHP (2) | 14 | 20 |
5 | K2S2O8 (2) | 14 | 69 |
6 | (NH4)2S2O8 (2) | 14 | 55 |
7 | K2S2O8 (2) | 42 | 0 c |
8 | K2S2O8 (2) | 8 | 65 d |
9 | K2S2O8 (2) | 0 | 0 e |
10 | K2S2O8 (3) | 14 | 68 |
11 | K2S2O8 (1.8) | 14 | 61 |
12 | K2S2O8 (2) | 14 | 54 f |
13 | K2S2O8 (2) | 14 | 80 g |
Entry | R | Yield (%) of 3 b |
---|---|---|
1 | 4-Cl | 63 (3a) |
2 | H | 52 (3b) |
3 | 4-CH3 | 55 (3c) |
4 | 3-Br | 48 (3h) |
5 | 3-CH3 | 51 (3i) |
6 | 4-Ph | 60 (3n) |
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Bian, Y.; Qu, X.; Chen, Y.; Li, J.; Liu, L. K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source. Molecules 2018, 23, 2225. https://doi.org/10.3390/molecules23092225
Bian Y, Qu X, Chen Y, Li J, Liu L. K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source. Molecules. 2018; 23(9):2225. https://doi.org/10.3390/molecules23092225
Chicago/Turabian StyleBian, Yongjun, Xingyu Qu, Yongqiang Chen, Jun Li, and Leng Liu. 2018. "K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source" Molecules 23, no. 9: 2225. https://doi.org/10.3390/molecules23092225